Relationship between Benign Prostatic Hyperplasia and History of Coronary Artery Disease in Elderly Men

Weisman, Kenneth; Larijani, Ghassem E.; Goldstein, Mark R.; Goldberg, Michael E.

doi:10.1592/phco.20.5.383.35053

Cited by 34 publications

(25 citation statements)

References 27 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a retrospective study involving 702 elderly males aged 65-80 years, it was reported that the frequency of coronary artery disease was higher (29%) in men with BPH (prostate specific antigen [PSA] [ 1 lg/l) compared to men without any BPH (PSA \ 1 pg/l) [47]. The association between these two disorders was also supported by various clinical trials.…”

Section: Ischemic Heart Diseasementioning

confidence: 93%

Benign prostatic hyperplasia: dietary and metabolic risk factors

Nandeesha¹

2008

Int Urol Nephrol

View full text Add to dashboard Cite

Benign prostatic hyperplasia (BPH) is the most common nonmalignant condition of the prostate occurring in ageing men. Even though BPH is a major public health problem, causing high morbidity and substantial worsening in men's quality of life, little is known about its risk factors. Several studies revealed that it is a multifactorial disease. Previous studies have documented family history, hormonal imbalance, and growth factors as etiological factors in the development of BPH. This review focuses on the dietary and metabolic risk factors including diabetes mellitus, hypertension, obesity, hyperinsulinemia, as well as dyslipidemia and their mechanisms in the pathogenesis of BPH.

show abstract

Section: Ischemic Heart Diseasementioning

confidence: 93%

Benign prostatic hyperplasia: dietary and metabolic risk factors

Nandeesha¹

2008

Int Urol Nephrol

View full text Add to dashboard Cite

show abstract

“…The association of BPH and heart disease, independent of other variables, had also been described [10,11], suggesting that both entities represent downstream manifestations of a common pathogenesis. Epidemiological study showed that elevated free PSA levels, heart disease, and the use of bblocker medications increase the risk of BPH [10].…”

Section: Introductionmentioning

confidence: 90%

Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study

Ajayi¹,

Adegun²,

Akanbi³

et al. 2017

CMR

View full text Add to dashboard Cite

Abstract:Ageing in men is associated with increased prevalence of cardiovascular risk factors and benign prostatic hyperplasia (BPH) with both entities possibly representing downstream manifestations of a common pathogenesis. There is paucity of data on the association of BPH and left ventricular hypertrophy (LVH). This study evaluated relationship between prostate volume, common cardiovascular risk factors and LVH. It was a cross sectional, prospective, hospital-based study. Thirty patients with benign prostatic enlargement (BPE) and 30 age-matched male controls without BPE were studied. All the subjects had clinical, biochemical, prostate ultrasound and echocardiographic evaluation done. SPSS IBM 20 was used to analyze data. Mean age was 65.60 ± 8.11 years (range: 54-82years). Subjects with BPE compared to those without did not significantly differ in age (66.50± 7.75 vs. 64.70±8.49; p=0.39). Significantly higher percentage of subjects with BPE had abnormally low HDL-cholesterol and high blood pressure compared with subjects without BPE. Eight (26.7%) of subjects with BPE in contrast to none of the subjects without BPE had metabolic syndrome (Chi2 = 9.231; p=0.002). Left ventricular mass index were significantly higher in subjects with BPE than in those without. None of the subjects without BPE as compared with 7 (23.3%) of subjects with BPE had echocardiographic determined LVH. Echocardiographic indices that significantly correlated with prostatic volume were: LVPWd (r=0.326, p= 0.011), IVSTd (r= 0.267, p=0.039), LVMI(r=0.308, p= 0.017), LAD (r= 0.494, p<0.0001) and AOD (r= 0.352, p= 0.006). The conclusion was that BPE is associated with increased left ventricular mass index and metabolic syndrome, mostly driven by elevated blood pressure and low serum HDL-cholesterol.

show abstract

“…However, the interpretation of these findings in the population context is difficult given the select sample (all of the men presumably had BPH). Weisman et al [24] examined the relationship between BPH and the history of coronary heart disease. They performed a chart review of 702 men seen in a urology practice.…”

Section: Cardiovascular Disease and Benign Prostatic Hyperplasiamentioning

confidence: 99%

Risk factors for benign prostatic hyperplasia

Jacobsen

2007

Curr Urol Rep

View full text Add to dashboard Cite

This review summarizes recent findings regarding risk factors for benign prostatic hyperplasia (BPH), including new data on hormonal factors, growth factors, comorbid conditions and lifestyle, diet, and exercise as they relate to BPH. In addition, it addresses the design and measurement issues that influence the inference that can be drawn from those studies. Most of the population-based studies on BPH have provided only modest insight into risk factors for BPH. The relationships with circulating levels of steroid hormones and growth factors are still unclear, whereas the association between sexual function and BPH is fairly consistent. Whether this represents a cause and effect relationship or is due to some unobserved confounding factor remains uncertain. There are few data on lifestyle factors that may be amenable to intervention. As future studies aim to address these issues, they should be carried out with rigorous methods, bypassing as many of the methodologic shortcomings of past studies as possible.

show abstract

Relationship between Benign Prostatic Hyperplasia and History of Coronary Artery Disease in Elderly Men

Abstract: Smooth muscle proliferation is an important and possibly androgen-dependent step in the development of atherosclerosis and BPH. Prospective studies are required to assess the effect of antiandrogens on atherosclerosis.

Cited by 34 publications

References 27 publications

Benign prostatic hyperplasia: dietary and metabolic risk factors

Benign prostatic hyperplasia: dietary and metabolic risk factors

Association Between Prostatic Volume, Metabolic Syndrome and Left Ventricular Mass: A Cross Sectional Study

Risk factors for benign prostatic hyperplasia

Contact Info

Product

Resources

About