Relationship between Baseline White Blood Cell and C-Reactive Protein with Mortality in Patients with Spontaneous Intracerebral Hemorrhage

Godoy, Daniel Agustín; Papa, Francesca; Campi, Verónica; Valle, Marta del; Piñero, Gustavo

doi:10.4172/2155-9562.1000104

Cited by 5 publications

(5 citation statements)

References 40 publications

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“…This finding is in accordance with Boersema et al [17]. The CRP has been shown to rise significantly in the current study, a finding that is similar to Godoy et al [18]. The explanation for the rise of CRP is most likely to inflammation that accompanies tissue injury at the time of surgery with an increase in hepatic production of this acute phase reactant [17].…”

Section: Discussionsupporting

confidence: 93%

“…The present study showed that the level of immune markers CD16 and MCP-1 became significantly higher during operation, whatever the type and duration of anesthesia, in comparison with their levels before operation, and that their level decreased significantly after operation; however, it did not return back to the same level before operation (with the exception of MCP-1 which returned back almost to the same level before operation). Natural killer cell is an important player of the innate immunity, and its count is expected to rise during physiologic stress [18].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Anesthesia on Innate Immune Components in Orthopedic Surgery

Aubaid

Yassen

2018

Asian J Pharm Clin Res

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Objectives: The present study was carried out to evaluate the possible role of anesthetics and surgery on innate by measuring the levels of tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ) by enzyme-linked immunosorbent assay (ELISA). Flow cytometry was used to determine MCP-I and CD16.Methods: Serum level of TNFα and IFNγ cytokines was measured using ELISA technique. Flow cytometry was used to determine MCP-I and CD16. White blood cell count and C-reactive protein (CRP) were determined.Results: There was a highly significant rise in CRP blood level postoperatively when compared with pre-operative blood level (p<0.001). In addition, the results revealed a significant rise in neutrophil count after operation in comparison with its baseline level before operation (p<0.001), while the level of lymphocytes showed significant decline following operation (p<0.001). The level of monocyte and eosinophil also got significantly reduced after operation (p<0.001), whereas the level of basophil showed no significant alteration after operation (p=0.687). CD16 NK cell count revealed a significant rise during the time of anesthesia. However, it showed a significant decrease postoperatively, but the reduction did not reach baseline count. It has been noticed also that the level of MCP-1 got raised significantly in association with anesthesia induction; however, it returned back to its baseline level following surgery.Conclusions: Analysis of data to correlate the innate immune components TNFα, IFNγ, MCP-I, and CD16 with types of anesthetic drugs (general, local, and regional anesthesia) showed no significant association between these components and type of anesthesia (p>0.05).

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effects of Anesthesia on Innate Immune Components in Orthopedic Surgery

Aubaid

Yassen

2018

Asian J Pharm Clin Res

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“…In the present study, we observed convincing relationships among baseline inflammatory markers (WBC count and CRP level) and mortality. These observations are in line with previous studies conducted involving WBC count (11,17) and also with studies of other inflammatory markers (6,7).…”

Section: Discussionsupporting

confidence: 92%

“…These findings were further reciprocated in another study (10). Autopsies conducted in both animals (11) and in human subjects (12) with SICH found leukocytic infiltration usually occurs within the first three days of insult, and further cascadial inflammatory changes in the penumbra of the haemorrhage following SICH come into play in management. Laboratory personnel were blinded to clinical information, and quality control of assay was maintained.…”

Section: Introductionmentioning

confidence: 68%

Inflammatory Biomarkers and Their Value in Predicting Survival and Outcome among Patients with Spontaneous Intracerebral Haemorrhage

Rajapathy

Idris

Kandasamy

et al. 2017

MJMS

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Results: A total of 60 patients with a mean age of 56 years were recruited in this study. We found that approximately 16 patients were less than or equal to 50 years old (26.7%) and that 44 patients belonged to the older age group of above 50 years (73.3%). The Glasgow Coma Scale (GCS) score on admission ranged from 9 to 14/15 with a median value of 11/15. The mean clot volume was 20.1 cm 3 . The GCS score on admission and clot volume were significantly associated with the Glasgow Outcome Scale (GOS) at 6 months and overall survival (P < 0.05). The elevated WBC count and CRP level on admission and at 72 hours post admission were significantly associated with GOS at 6 months and overall survival (P < 0.05). Thus, the GCS score, clot volume, WBC count and CRP levels on admission and at 72 hours post admission can be used to predict functional outcome at 6 months and overall survival in patients with SICH.Conclusion: We could conclude via this study that for patients with SICH, the main determinants or predictors of functional outcome at 6 months and overall survival were noted to

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“…Chronic inflammatory demyelinating polyneuropathy (CIDP) is considered to be an autoimmune disorder of the peripheral nervous system. It has been experimented that the measurement of visual evoked potentials was a useful technique for the diagnosis of visual pathway involvement, but was of no value for monitoring the effect of treatment in CIDP patients [52,53]. Compounds acting specifically to antagonise excitatory neurotransmission offer a novel therapeutic approach to these disorders [54].…”

Section: Therapeutic Analysismentioning

confidence: 99%

Epigenetic and Therapeutic Analysis of various Neurological Disorders

Tripathy¹

2011

J Genet Syndr Gene Ther

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Neurological disorders are diseases of the central and peripheral nervous system. In this Review, It has been analysed epigenetic changes present in neurological diseases and discussed its therapeutic potential. The article has reviewed advances and considers approaches that may provide hope for alleviation of the disorders. This also reviews in this supplement focus on the neurobiology of a variety of these diseases of the central nervous system (CNS), including epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS).

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Relationship between Baseline White Blood Cell and C-Reactive Protein with Mortality in Patients with Spontaneous Intracerebral Hemorrhage

Cited by 5 publications

References 40 publications

Effects of Anesthesia on Innate Immune Components in Orthopedic Surgery

Effects of Anesthesia on Innate Immune Components in Orthopedic Surgery

Inflammatory Biomarkers and Their Value in Predicting Survival and Outcome among Patients with Spontaneous Intracerebral Haemorrhage

Epigenetic and Therapeutic Analysis of various Neurological Disorders

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