Epigenetic and Therapeutic Analysis of various Neurological Disorders

Tripathy, Kadambini

doi:10.4172/2157-7412.1000111

Cited by 2 publications

(2 citation statements)

References 71 publications

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“…Healthy regulation and balance of the neurotransmitters are essential to the homeostasis of the body since chronic neurodegenerative diseases often have mitochondrial and neuroinflammation dysfunctions. Inflammation processes are manifested in many diseases and disorders such as cerebral palsy, epilepsy, autism, post-traumatic stress disorder (PTSD), as well as autoimmune diseases [1][2][3]. The elevation of cortisol in these conditions becomes the driving factor for increased levels of phenylethanolamine N-methyltransferase (PMNT).…”

Section: Introductionmentioning

confidence: 99%

The Impact of MNRI Therapy on the Levels of Neurotransmitters Associated with Inflammatory Processes

Tatarinova

Deiss²,

Franckle

et al. 2020

IJMS

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The neurotransmitter levels of representatives from five different diagnosis groups were tested before and after participation in the MNRI®—Masgutova Neurosensorimotor Reflex Intervention. The purpose of this study was to ascertain neurological impact on (1) Developmental disorders, (2) Anxiety disorders/OCD (Obsessive Compulsive Disorder), PTSD (Post-Traumatic Stress disorder), (3) Palsy/Seizure disorders, (4) ADD/ADHD (Attention Deficit Disorder/Attention Deficit Disorder Hyperactive Disorder), and (5) ASD (Autism Spectrum Disorder) disorders. Each participant had a form of neurological dysregulation and typical symptoms respective to their diagnosis. These diagnoses have a severe negative impact on the quality of life, immunity, stress coping, cognitive skills, and social assimilation. This study showed a trend towards optimization and normalization of neurological and immunological functioning, thus supporting the claim that the MNRI method is an effective non-pharmacological neuromodulation treatment of neurological disorders. The effects of MNRI on inflammation have not yet been assessed. The resulting post-MNRI changes in participants’ neurotransmitters show significant adjustments in the regulation of the neurotransmitter resulting in being calmer, a decrease of hypervigilance, an increase in stress resilience, behavioral and emotional regulation improvements, a more positive emotional state, and greater control of cognitive processes. In this paper, we demonstrate that the MNRI approach is an intervention that reduces inflammation. It is also likely to reduce oxidative stress and encourage homeostasis of excitatory neurotransmitters. MNRI may facilitate neurodevelopment, build stress resiliency, neuroplasticity, and optimal learning opportunity. There have been no reported side effects of MNRI treatments.

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Section: Introductionmentioning

confidence: 99%

The Impact of MNRI Therapy on the Levels of Neurotransmitters Associated with Inflammatory Processes

Tatarinova

Deiss²,

Franckle

et al. 2020

IJMS

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“…Epigenetic alterations are involved in a diverse set of processes and implicated in a variety of mental disorders and somatic diseases. The reversibility of epigenetic defects makes epigenetic disorders and diseases amenable to therapeutics (Shamsi et al 2017) while the identification of epigenetic dysfunctions gives an opportunity to consider new treatment approaches (Tripathy 2011). The concept of translational medicine implies the application of latest scientific research in diagnostics, prevention and treatment of diseases, all in the spirit of evidence based medicine for the best patients' outcome.…”

Section: Introductionmentioning

confidence: 99%

Epigenetics, Resilience, Comorbidity and Treatment Outcome

Jakovljević

Borovečki

2018

Psychiat Danub

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Personalized or precision medicine is a relatively new promising concept which is gaining momentum in all branches of medicine including psychiatry and neurology. Psychiatry and neurology are medical specialties dealing with diagnosis, prevention and treatment of brain disorders which are the main causes of years lived with disability worldwide as well as shortened life. Despite a huge progress in clinical psychopharmacology and neuropharmacology, the treatment outcome for many psychiatric disorders and neurologic diseases has remained unsatisfactory. With aging, comorbidities are more the rule, than an exception and may significantly influence on the final treatment outcome. Epigenetic modulation, resilience and life style are key determinants of the health and very important issues for understanding therapeutic mechanisms and responses. There is a hope that epigenetic profiling before treatment could be used in near future to increase the likelihood of good treatment response by selecting the appropriate medication. The aim of this paper is to offer an overview of the main aspects of epigenetic modulation, resilience and comorbidities and their role in developing the concept of personalized medicine. While waiting for more precise and reliable treatment guidelines it is possible to increase treatment effectiveness in psychiatry and neurology by enhancing individual resilience of patients and managing comorbidities properly.

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Epigenetic and Therapeutic Analysis of various Neurological Disorders

Cited by 2 publications

References 71 publications

The Impact of MNRI Therapy on the Levels of Neurotransmitters Associated with Inflammatory Processes

The Impact of MNRI Therapy on the Levels of Neurotransmitters Associated with Inflammatory Processes

Epigenetics, Resilience, Comorbidity and Treatment Outcome

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