Relationship between arterial, mixed venous, and internal jugular carboxyhemoglobin concentrations at low, medium, and high concentrations in a piglet model of carbon monoxide toxicity

Abstract

Venous COHb concentrations predict arterial COHb concentrations with a high degree of accuracy and are correlated at low, moderate, and high concentrations of carbon monoxide exposure. Arterial or venous samples can be used to accurately measure COHb concentrations.

Carboxyhemoglobin measurement by hospitals: Implications for the diagnosis of carbon monoxide poisoning

“…Despite the fact that arterial and venous COHb levels have a high correlation at low, medium and high concentrations (13), only about one-half of laboratories surveyed will measure COHb on either type of sample. Because of this, many unnecessary samples are undoubtedly being obtained.…”

Carbon monoxide poisoning

“…Arterial sampling is not necessary because prospective comparison of arterial and venous CO-Hgb levels in poisoned patients has shown a high degree of correlation [153]. In an animal model, the accuracy was maintained at CO-Hgb levels exceeding 60% [154].…”

Application of CO-oximeter for Forensic Samples

“…There was a good correlation between the COHb values obtained by AVOX and by the conventional method [23]. No arterialvenous diference of COHb concentration was observed at the level less than 75% of COHb [23] and in animal experiments [48].…”