Relationship and prognostic significance between preoperative serum albumin to globulin ratio and CT features of non-small cell lung cancer

Guo, Xiaoli; Shao, Jingjing; Zhai, Baoqian; Zou, Qijiu; Yan, Jiaxin; Gaoren, Wang

doi:10.1016/j.ejrad.2020.109039

Cited by 15 publications

(14 citation statements)

References 38 publications

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“…Some studies concluded that patients with a relatively low level of AGR had a better prognosis in NSCLC ( 43 ). However, the present study drew a different conclusion, indicating that patients whose AGR ≥1.375 had a better survival than those not, similarly to previous research ( 44 ). Aspartate aminotransferase (AST) ubiquitously exists mainly in cardiomyocytes and hepatocytes, participating in amino acid metabolism and tricarboxylic acid cycles.…”

Section: Discussionsupporting

confidence: 80%

The Prognostic Value of Multiple Systemic Inflammatory Biomarkers in Preoperative Patients With Non-small Cell Lung Cancer

et al. 2022

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IntroductionThe preoperative inflammatory and nutrient status of the patient are closely correlated to the outcome of surgery-based treatment for non-small cell lung cancer (NSCLC). We aimed to investigate the prognostic value of inflammation and nutrient biomarkers in preoperative patients with non-small cell lung cancer (NSCLC) by constructing a prognostic predictive model.MethodsWe retrospectively studied 995 patients with NSCLC who underwent surgery in the Shandong Provincial Hospital and randomly allocated them into the training and validation group with a ratio of 7:3. We then compared their prognostic performance and conducted univariate Cox analyses with several clinicopathological variables. Based on the performance of the receiver operating characteristic (ROC) curves and decision curves analysis (DCA), the prognostic model was optimized and validated.ResultThe median overall overall survival (OS) of patients was 74 months. Univariate Cox analysis indicated that fifteen inflammatory biomarkers were significantly correlated with OS (p < 0.100). Multivariate Cox analysis revealed that the model incorporating grade, age, stage, basophil-to-lymphocyte ratio (BLR, ≥0.00675 vs. < 0.00675) and albumin-to-globulin ratio (AGR, ≥1.40 vs. <1.40) showed the maximum area under the curve (AUC, 0.744). The C-index in the training and validation group was 0.690 and 0.683, respectively. The 3-year integrated discrimination improvement (IDI) compared to TNM (Tumor Node Metastasis) stage was 0.035 vs. 0.011 in the training and validation group, respectively.ConclusionsLower AGR, ANRI, and higher BLR were associated with a worse outcome for patients with NSCLC. We constructed a prognostic nomogram with risk stratification based on inflammatory and nutrient biomarkers. The discrimination and calibration abilities of the model were evaluated to confirm its validity, indicating the potential utility of this prognostic model for clinical guidance.

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Section: Discussionsupporting

confidence: 80%

The Prognostic Value of Multiple Systemic Inflammatory Biomarkers in Preoperative Patients With Non-small Cell Lung Cancer

et al. 2022

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“…International Journal of General Medicine 2021:14 7356 some albumin-based ratio for the diagnostic and prognostic of lung cancer. [40][41][42] However, to the best of our knowledge, limited data are available on the combination of BUN and serum albumin for the prognosis of patients with lung cancer considering that the increased BUN and decreased serum albumin levels are in agreement with previous studies. In the current study, we retrospectively enrolled 2209 ICU patients with lung cancer using two large free public databases and noted a positive correlation between BAR and the prognosis of patients.…”

Section: Dovepressmentioning

confidence: 70%

Prognostic Value of Blood Urea Nitrogen to Serum Albumin Ratio in Intensive Care Unit Patients with Lung Cancer

Peng¹,

Huang²,

Fu³

et al. 2021

IJGM

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“…Patients with good nutrition and healthy livers, producing normal amounts of albumin, have good resistance to disease and tumor growth. Albumin is inhibited by inflammatory cytokines, such as tumor necrosis factor-a, IL-1, and IL-6, which promote tumor development (18). Since cancer affects its metabolism, albumin can be used to reflect physical conditions.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of the Preoperative Controlled Nutritional Status Score in Lung Cancer Patients Undergoing Surgical Resection

Shao

Zhang

et al. 2020

Nutrition and Cancer

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Relationship and prognostic significance between preoperative serum albumin to globulin ratio and CT features of non-small cell lung cancer

Cited by 15 publications

References 38 publications

The Prognostic Value of Multiple Systemic Inflammatory Biomarkers in Preoperative Patients With Non-small Cell Lung Cancer

The Prognostic Value of Multiple Systemic Inflammatory Biomarkers in Preoperative Patients With Non-small Cell Lung Cancer

Prognostic Value of Blood Urea Nitrogen to Serum Albumin Ratio in Intensive Care Unit Patients with Lung Cancer

Prognostic Significance of the Preoperative Controlled Nutritional Status Score in Lung Cancer Patients Undergoing Surgical Resection

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