The Prognostic Value of Multiple Systemic Inflammatory Biomarkers in Preoperative Patients With Non-small Cell Lung Cancer

Wang, Kai; Zhao, Qidi; Yan, Tao; Guo, Deyu; Liu, Jichang; Wang, Guanghui; Du, Jiajun

doi:10.3389/fsurg.2022.830642

Cited by 8 publications

(6 citation statements)

References 55 publications

(56 reference statements)

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“…[32,33] Previous reports have determined the relationship between basophils and the survival outcome of pancreatic cancer, [34] colorectal cancer, [19] and non-small cell lung cancer. [35] A recent report found that the ratio of basophils negatively associate with the number of visceral lung metastatic sites in tumor-bearing mice. [36] Hadadi et al [37] reported that higher levels of baseline basophils were associated with worse survival in patients with prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of platelet-to-basophil ratio (PBR) in patients with primary glioblastoma

Yang

Wang

et al. 2023

Medicine

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Inflammation is strongly associated with cancers. Our research explored the prognostic role of hematological inflammatory indicators in patients with glioblastoma (GBM). Hundred patients were incorporated finally, and we determined the best cutoff values of these blood markers through X-tile first to perform further survival tests. The prognostic role of peripheral blood cell count and corresponding ratios were assessed using the Kaplan–Meier curve and Cox models to identify variables with independent prognostic significance. Then, variables with independent predictive values were incorporated in constructing the nomogram model to realize quantitative prediction for survival. Nomograms were evaluated using Harrell concordance index, receiver operating characteristic curves, and decision curve analysis to assess clinical benefit. Multivariate analysis indicated that a higher platelet-to-basophil ratio (PBR) (>4575) (hazard ratio = 1.819, 95% confidence interval: 1.110–2.980, P = .018) was associated with poorer overall survival in GBM patients. Based on the PBR nomogram, the predictive accuracy was moderate (concordance index = 0.844, area under curve = 0.632). The PBR could serve as a prognostic biomarker for overall survival in patients with GBM, and nomogram models incorporating the PBR could facilitate comprehensive preoperative survival assessment.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of platelet-to-basophil ratio (PBR) in patients with primary glioblastoma

Yang

Wang

et al. 2023

Medicine

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“…The prognostic roles of BLR and ELR in cancers remain unclear due to rare published studies. Recently, it has been reported that elevated BLR was correlated with improved overall survival in patients with non-small cell lung cancer [21,22]. In addition, BLR was identified to be an independent prognostic factor for distant recurrence-free survival in cervical cancer [23].…”

Section: Introductionmentioning

confidence: 97%

Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), and Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease.

Liao¹,

Mo²,

Zhu³

et al. 2022

Preprint

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The study comprehensively evaluated the prognostic roles of PLR, NLR, MLR, BLR, and ELR in patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD). 619 patients with AECOPD and 300 healthy volunteers were retrospectively included into the study. The clinical characteristics containing laboratory findings of the AECOPD patients and the blood cell counts (CBCs) of the healthy volunteers were collected. Compared with the healthy volunteers, PLR, NLR, and MLR were elevated in COPD patients in stable condition, and were further ele-vated during exacerbation. ELR showed the opposite trend. PLR, NLR, and MLR were all posi-tively correlated with hospital LOS as well as CRP. In contrast, ELR was negatively correlated with hospital LOS as well as CRP. Elevated PLR, NLR, and MLR were all associated with more serious airflow limitation in AECOPD. Elevated PLR, NLR, and MLR were all associated with increased in-hospital mortality while Elevated ELR was associated with decreased in-hospital mortality in AECOPD. A nomogram was construct to predict in-hospital mortality in AECOPD. The nomo-gram had a C-index of 0.850 (95% CI: 0.799 – 0.901) with good predictive value and clinical ap-plicability. In summary, PLR, NLR, MLR, and ELR served as predictors for clinical outcomes in patients with AECOPD.

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“…Contrary to PLR, NLR, and MLR, increased ELR was correlated with reduced hospital LOS and in-hospital mortality in AECOPD. Increased BLR is a poor prognostic factor for clinical outcomes in metastatic hormone sensitive prostate cancer as well as NSCLC [12,13].The present study investigate the prognostic value of systemic in ammatory factors including PLR, NLR, MLR, BLR, and ELR in patients with SCAP.…”

mentioning

confidence: 92%

Evaluation of the prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)

Cui

Xie

Zhu³

et al. 2023

Preprint

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Background: Severe community-acquired pneumonia (SCAP) is a serious respiratory inflammation disease with high morbidity and mortality. This study aimed to evaluate the prognostic value of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR) and eosinophil-to-lymphocyte ratio (ELR) in patients with severe community-acquired pneumonia (SCAP). Methods: The study retrospectively included 554 patients with SCAP and healthy volunteers, and the clinical data were obtained from the electronic patient record (EMR) system. The primary outcome was in-hospital mortality, and the secondary outcomes included hospital length of stay (LOS), overall survival (OS), admission to the intensive care unit (ICU), ICU LOS, and ICU mortality. The correlations of systemic inflammatory factors (PLR, NLR, MLR, BLR, and ELR) with primary and secondary outcomes were analyzed. Results: In the patients with SCAP, both NLR and BLR were significant but independent risk factors for in-hospital mortality; NLR was negatively correlated with hospital LOS while ELR was positively correlated with hospital LOS; both increased NLR and BLR were associated with reduced OS, while increased ELR was associated with improved OS; increased PLR, NLR, MLR, and BLR were all correlated with elevated ICU admission rates, while increased ELR was correlated with reduced ICU admission rates; ELR was positively correlated with ICU LOS, whereas PLR, NLR, MLR, or BLR had no significant correlation with ICU LOS; both higher NLR and BLR were associated with elevated ICU mortality; PLR, NLR, and MLR were improved while ELR was lowered in patients with SCAP compared to healthy volunteers; PLR, NLR, and MLR were reduced while ELR was elevated when the patients were in recovery after treatment. Furthermore, BLR was elevated in patients with SCAP compared with healthy volunteers. Conclusions: NLR and BLR were useful biomarkers for clinical outcomes in patients with SCAP.

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The Prognostic Value of Multiple Systemic Inflammatory Biomarkers in Preoperative Patients With Non-small Cell Lung Cancer

Cited by 8 publications

References 55 publications

Prognostic value of platelet-to-basophil ratio (PBR) in patients with primary glioblastoma

Prognostic value of platelet-to-basophil ratio (PBR) in patients with primary glioblastoma

Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), and Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease.

Evaluation of the prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)

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