Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review

Chin, Kok‐Yong; Pang, Kok-Lun; Wong, Sok Kuan; Chew, Deborah Chia Hsin; Qodriyah, Haji Mohd Saad

doi:10.1007/s40266-022-00945-y

Cited by 3 publications

(2 citation statements)

References 76 publications

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“…Было показано, что ВКЗП, а именно остеокальцин, матриксный Gla-протеин (MGP) и, в последнее время, Gla-богатый-протеин (GRP), связаны с OA. Клиническое исследование с участием 25 японских пациентов с двусторонним ОА коленного сустава определило уровни ucOC в сыворотке и продемонстрировало, что некарбоксилированный остеокальцин может быть полезным маркером для оценки патофизиологического состояния коленного ОА [61]. Результаты экспериментов in vitro и ex vivo показали, что некарбоксилированный MGP (ucMGP) был связан с повышенной минерализацией хряща при ОА, предполагается, что дефицит витамина К может способствовать патологической минерализации при ОА [62].…”

Section: витамин к и возраст-ассоциированные заболеванияunclassified

Vitamin K and age-related diseases

Ерусланова

Onuchina

Ivannikova

et al. 2023

Rossiiskii zhurnal geriatricheskoi meditsiny

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Section: витамин к и возраст-ассоциированные заболеванияunclassified

Vitamin K and age-related diseases

Ерусланова

Onuchina

Ivannikova

et al. 2023

Rossiiskii zhurnal geriatricheskoi meditsiny

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“…Of these, glucocorticoid use is the most important cause of medication-induced osteoporosis due to its prevalent use and its potent effect in inhibiting osteogenesis through various direct and indirect mechanisms [ 112 ]. Warfarin use is a significant risk factor for bone loss because it affects the vitamin K-dependent protein carboxylation process [ 113 , 114 ]. The use of non-vitamin K antagonist oral anticoagulants is reported to be associated with a lower risk of fracture compared with warfarin users, especially with long-term usage [ 115 ].…”

Section: Risk Factors Of Osteoporosismentioning

confidence: 99%

A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss

Chin

Rostam

et al. 2022

JCM

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Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass and microarchitecture, which compromises bone strength. It is a complex multifactorial endocrine disease. Its pathogenesis relies on the presence of several endogenous and exogenous risk factors, which skew the physiological bone remodelling to a more catabolic process that results in net bone loss. This review aims to provide an overview of osteoporosis from its biology, epidemiology and clinical aspects (detection and pharmacological management). The review will serve as an updated reference for readers to understand the basics of osteoporosis and take action to prevent and manage this disease.

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Prevalence and progression of arterial calcifications on computed tomography in humans with knee osteoarthritis

de Jong,

Harlianto,

Foppen

et al. 2024

Rheumatology

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Objectives Ectopic bone deposition plays an important role in osteoarthritis (OA) and in arterial wall disease. We aimed to investigate the prevalence and progression of arterial calcifications on whole-body computed tomography (CT) in persons with knee OA. Methods We included 118 (36 male) participants who satisfied the clinical American College of Rheumatology classification criteria for knee OA. Baseline investigations included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence grading. At baseline and after two years, a whole-body CT was performed using the same scanner and protocol. Calcifications were quantified in the carotid, brachiocephalic, coronary, thoracic aortic, abdominal aortic, iliac, femoropopliteal and crural arteries. Multivariable linear and logistic regression modeling was used for analyses. Results At baseline males were 66.9 ± 7.7 and females were 68.0 ± 5.6 years old. Calcifications were common, all participants except two females had some calcification, and prevalence ranged between 41.8% and 94.4% for various arterial beds. Baseline femoropopliteal calcifications were associated with a higher Kellgren-Lawrence grade (more severe knee OA). Median annual progression rate was 13.1% in males and 15.7% in females. Structural OA severity was not associated with progression, but a five points lower (worse) WOMAC was associated with 1% faster progression of arterial calcifications (p= 0.008). Conclusion Around age 70 nearly all persons with knee OA have arterial calcifications, which progress substantially. For further investigation into shared causality intervention studies are needed.

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Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review

Cited by 3 publications

References 76 publications

Vitamin K and age-related diseases

Vitamin K and age-related diseases

A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss

Prevalence and progression of arterial calcifications on computed tomography in humans with knee osteoarthritis

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