Relations between vitamin D3, total and specific IgE for house dust mites in atopic dermatitis patients

Ibrahim, Hassan; Taieb, Moustafa A El; Hassan, Mohammed H.; Mohamed, Abd Allah E; Kotop, Ebtihal A; AbdEllah, Osama Hussein; Hegazy, Eisa M.

doi:10.1038/s41598-020-77968-1

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Yazıcı et al [12] studied sensitization in a group of children with AD, AR, asthma, and urticaria using skin tests. 32.7% were sensitive to Der f and 30.4% to Der p. In the Ibrahim HM study [13], 44% (n = 22) of patients were positive for serum IgE to HDM extract. González-Pérez et al [14] found in 80 patients with AD that the major allergens (Der p 23, Der p 2, and Der p 1) were present in more than 86% of all subjects, regardless of severity.…”

Section: Discussionmentioning

confidence: 91%

House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism

Mozyrska¹

2022

pja

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Introduction: Sensitization to house dust mites is common in patients with atopic dermatitis. Dectin-1 polymorphism can affect the recognition of house dust mite allergens in the skin. Aim: To investigate the prevalence of sensitization to house dust mites in children with atopic dermatitis and the role of Dectin-1 rs7309123 polymorphism in the development of sensitivity to house dust mites. Material and methods:The study included 101 patients with atopic dermatitis. Genotyping of the Dectin-1 rs7309123 was performed in the patient group using real-time PCR. Measurements of sIgE to dust mites were performed by Western blotting. Results: Sensitization to house dust mites was found in 48.5% of the children. The presence of sIgE to HDM in patients with AD was significantly associated with concomitant allergic rhinitis (OR = 2.593 (1.096-6.133)) and in the group of children with both concomitant allergic diseases ). There was statistically significant difference in the distribution of genotypes in patients with elevated serum IgE to HDM and among the children with normal levels for CG and GG). Conclusions:The susceptibility to dust mites among children with atopic dermatitis is 48.5%. Dectin-1 is involved in the development of HDM-induced allergic inflammation in skin because polymorphism rs7309123 of the Dectin-1 gene may affect percutaneous sensitization to HDM in patients with AD, and the inhibition of signalling pathways of Dectin-1 may be an efficient therapeutic strategy.

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Section: Discussionmentioning

confidence: 91%

House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism

Mozyrska¹

2022

pja

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“…Подобные результаты представлены H.M. Ibrahim и соавт. (r = -0,62; p < 0,001) [73] и Y.M. Jang и соавт.…”

Section: ассоциация концентрации 25(он)d в сыворотке крови с тяжестью...unclassified

Prevalence of Vitamin D Insufficiency/Deficiency and Their Role in Atopic Dermatitis Development and Course in Children

Kashinskaya

Шахова

Lobanov

et al. 2022

Vopr. sovr. pediatr.

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Various conclusive evidence on the role of vitamin D in the pathogenesis of atopic dermatitis (AD) has been obtained in recent decades. Many studies have shown that patients with AD have low concentration of 25(OH)D in blood associated with high concentration of allergen specific IgE (according to several reports). The analysis of low 25(OH)D concentration prevalence, association of vitamin D deficiency with AD severity and sensitization to allergens, and association of vitamin D disorders with risk of AD development is presented.

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“…There have been many studies linking atopic dermatitis with dust mites. A recent study has linked levels of vitamin D3 and the severity of atopic dermatitis symptoms from dust mite allergies [54]. However, long-term trials of house dust mite reduction methods are needed [53].…”

Section: Skin Conditions and Textile Relationshipmentioning

confidence: 99%

The Future of Functional Clothing for an Improved Skin and Textile Microbiome Relationship

2021

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The skin microbiome has become a hot field of research in the last few years. The emergence of next-generation sequencing has given unprecedented insights into the impact and involvement of microbiota in skin conditions. More and more cosmetics contain probiotics or bacteria as an active ingredient, with or without scientific data. This research is also acknowledged by the textile industry. There has been a more holistic approach on how the skin and textile microbiome interacts and how they influence the pH, moisture content and odour generation. To date, most of the ingredients have a broad-spectrum antibacterial action. This manuscript covers the current research and industry developments in the field of skin and textiles. It explores the nature of antimicrobial finishing in textiles which can disrupt the skin microbiome, and the benefits of more natural and microbiome friendly therapies to combat skin conditions, malodour and skin infection.

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Relations between vitamin D3, total and specific IgE for house dust mites in atopic dermatitis patients

Cited by 9 publications

References 28 publications

House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism

House dust mite sensitivity in atopic children with Dectin-1 rs7309123 polymorphism

Prevalence of Vitamin D Insufficiency/Deficiency and Their Role in Atopic Dermatitis Development and Course in Children

The Future of Functional Clothing for an Improved Skin and Textile Microbiome Relationship

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