Relation between serum levels of tissue polypeptide antigen (TPA) and cancer antigen 125 (CA125) and their immunohistochemical identification in benign and malignant gynecological disease

Fukazawa, I.; Inaba, Noriyuki; Ota, Yoriko; Sato, Naomi; Shirotake, S; Iwasawa, H.; Sato, Takahiro; Takamizawa, H; Wiklund, B.

doi:10.1007/bf00931550

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…Data comparing CEA (23-25) and CA-125 (31-33) antigen expression in ovarian tumor tissue with corresponding serum levels are limited. The present results confirm and extend the findings in two smaller studies reported by Breitenecker et al (31), and Fukazawa et al (32). In a previous investigation the present authors found that, in patients with invasive epithelial ovarian carcinoma the major determinants for the serum levels of CA-125 and CEA were the histologic type of the tumor and the clinical stage or tumor bulk (s), The present results are consistent with these findings.…”

Section: Discussionsupporting

confidence: 93%

Immunohistochemical detection of CA-125 and carcinoembryonic antigen in ovarian tumors in relation to corresponding preoperative serum levels

Tholander¹,

Lindgren

Taube

et al. 1992

Int J Gynecol Cancer

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The immunohistochemically detectable expression of CA-125 and CEA in ovarian tumor tissue from 187 patients was related to corresponding preoperative serum levels. A strong positive association between tissue expression and the serum level of both the CA-125 and CEA antigens was found in cases of invasive epithelial ovarian carcinoma. However, this relationship was absent for CA-125 in borderline cases and patients with benign ovarian tumors, although the antigen frequently was detectable in them. The presence of ascites could be verified in 3 of 10 cases with benign CA-125 negative tumors, but elevated CA-125 levels in serum. 'False negative' CA-125 levels were found in 6 borderline and 7 true invasive carcinoma cases despite positive tissue staining. Eight of those patients had limited stage I disease. The data suggests that although the tissue expression of the CA-125 and CEA antigens in invasive ovarian carcinoma has an important influence in the corresponding serum level, compartment barriers and low cell turnover in benign, and to a lesser extent borderline, cases result in low serum levels. In addition, other factors influence serum levels of CA-125, such as secondary peritoneal response with or without ascites, which may cause 'falsely elevated' CA-125 results in benign disease.

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Section: Discussionsupporting

confidence: 93%

Immunohistochemical detection of CA-125 and carcinoembryonic antigen in ovarian tumors in relation to corresponding preoperative serum levels

Tholander¹,

Lindgren

Taube

et al. 1992

Int J Gynecol Cancer

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“…Similar correlations have been reported in patients with bronchial cancer (8), cancer of the ovary (9), prostate cancer (lo), breast cancer ( 11) and gynecologic tumors (12).…”

supporting

confidence: 78%

“…Some efficacy has been demonstrated in monitoring malignancies of prostate, bladder, ovary, lung, stomach, pancreas and bile ducts, intestine, cervix, and breast (5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Tissue Polypeptide Antigen (TPA) in Head and Neck Carcinomas

Becciolini¹,

Porciani²,

Lanini³

et al. 1993

Acta Oncologica

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“…These results suggests that PP4 might be a more useful tumor marker for uterine carcinoma than TPA, CEA and SCC, which are commonly used. In endometrial carcinoma, frequencies of elevated serum levels of TPA and CEA have been reported to be 50% [7] and 27% [20], respectively. In cervical carcinoma, those of SCC and CEA were found to be 52-55% [18] and 35% [5], respectively.…”

Section: Discussionmentioning

confidence: 98%

Enzyme immunoassay for placental protein 4 (PP4) and its possible diagnostic significance in patients with genital tract cancer

Ota

Inaba

Shirotake

et al. 1990

Arch Gynecol Obstet

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We have established an enzyme immunoassay for placental protein 4 (PP4), by using avidin-biotin binding reaction, and set its normal range below 10.9 ng/ml (mean + 2 sigma). Throughout the menstrual cycle, the serum PP4 profile was similar to that of serum progesterone. In the follicular and ovulatory phase, PP4 remained relatively low, with the mean levels of 1.5 ng/ml and 1.8 ng/ml, respectively. In the luteal phase, the mean level was 3.2 ng/ml. In normal pregnancy, serum PP4 levels were low irrespective of gestational age, with a mean level of 3.0 ng/ml. There was only one case in which the serum PP4 level over 10.9 ng/ml. Mean serum PP4 levels and the frequencies of elevated serum PP4 levels were respectively 6.3 ng/ml and 11% in patients with benign ovarian neoplasms, 4.7 ng/ml and 6% in patients with endometriosis, and 5.5 ng/ml and 18% in patients with uterine myomata. The frequency of raised PP4 levels was 48% and the mean value was 13.3 ng/ml in patients with endometrial carcinoma, and the values were 44% and 13.4 ng/ml respectively in patients with cervical carcinoma. In patients with ovarian malignancy, the respective values were 15% and 7.0 ng/ml. The results did not relate to clinical stages of disease (FIGO), while the frequencies of elevated serum PP4 in patients with uterine carcinoma was over 40% in stage I diseases. Compared with other tumor markers such as carcino-embryonic antigen (CEA), tissue polypeptide antigen (TPA) and cancer antigen 125 (CA125), PP4 seems to be more promising as a marker of endometrial carcinoma.(ABSTRACT TRUNCATED AT 250 WORDS)

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Relation between serum levels of tissue polypeptide antigen (TPA) and cancer antigen 125 (CA125) and their immunohistochemical identification in benign and malignant gynecological disease

Cited by 10 publications

References 13 publications

Immunohistochemical detection of CA-125 and carcinoembryonic antigen in ovarian tumors in relation to corresponding preoperative serum levels

Immunohistochemical detection of CA-125 and carcinoembryonic antigen in ovarian tumors in relation to corresponding preoperative serum levels

Prognostic Significance of Tissue Polypeptide Antigen (TPA) in Head and Neck Carcinomas

Enzyme immunoassay for placental protein 4 (PP4) and its possible diagnostic significance in patients with genital tract cancer

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