Abstract:The immunohistochemically detectable expression of CA-125 and CEA in ovarian tumor tissue from 187 patients was related to corresponding preoperative serum levels. A strong positive association between tissue expression and the serum level of both the CA-125 and CEA antigens was found in cases of invasive epithelial ovarian carcinoma. However, this relationship was absent for CA-125 in borderline cases and patients with benign ovarian tumors, although the antigen frequently was detectable in them. The presence… Show more
“…10,[27][28][29][30] In the current study, 22 of 77 patients (29%) with benign ovarian neoplasms had elevated CA-125-II levels, whereas one of the three markers was elevated in 32 of 77 patients (42%). Again, this difference did not achieve statistical significance.…”
“…10,[27][28][29][30] In the current study, 22 of 77 patients (29%) with benign ovarian neoplasms had elevated CA-125-II levels, whereas one of the three markers was elevated in 32 of 77 patients (42%). Again, this difference did not achieve statistical significance.…”
“…Serum CA 125 level also depends on the dilution of the marker in the general circulation and its degradation and excretion from the body [8]. Some authors have stated that the serum CA 125 value is directly and positively related to the expression of the marker in tissue [9]. Such a realation was also indicated in our study but was not statistically significant (p = 0.052).…”
No reliable conclusions could be drawn on the influence of the studied parameters on expression of CA 125 in tissue and serum. The effect of tumor grade seems to be the strongest influence, particularly on CA 125 expression in serum, but it is not independent.
“…There have been previous reports that benign conditions including benign ascites, peritonitis and pelvic inflammatory disease can cause elevated CA-125 serum levels [9][10][11] . Falsely elevated CA-125 serum levels have been described in patients with CA-125negative ovarian cancer 16 and, interestingly, in a patient with a CA-125-negative rhabdomyosarcoma 17 . We found no nonmalignant disorder in our patient that might have caused her CA-125 serum levels to be falsely elevated and she also did not have ascitis or pleural involvement that might have explained our findings.…”
Section: Discussionmentioning
confidence: 99%
“…We found no nonmalignant disorder in our patient that might have caused her CA-125 serum levels to be falsely elevated and she also did not have ascitis or pleural involvement that might have explained our findings. Finally, discrepancies between CA-125 tumor staining and serum levels may be due to sensitivity problems of the immunohistochemical staining method in formalin-fixed and paraffin-embedded tissue, as previously described 16 .…”
When elevated, beta-HCG serum levels in patients with osteosarcoma might be used to monitor treatment. Treatment of advanced osteosarcoma with tyrosine kinase inhibitors, including E7080, warrants further investigation.
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