Prognostic Significance of Tissue Polypeptide Antigen (TPA) in Head and Neck Carcinomas

Becciolini, Aldo; Porciani, Sauro; Lanini, Aldo; Tommasi, M; Olmi, P.; Chiavacci, A.

doi:10.3109/02841869309093598

Cited by 4 publications

(1 citation statement)

References 11 publications

(18 reference statements)

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“…A previous study demonstrates that patients with head and neck carcinoma show baseline values significantly higher than the cut-off [5]. This level was assessed in 40 healthy subjects and resulted, according to the literature, in 85 U/1 (mean + SEM: 45.87 _+ 2.97 U/l).…”

Section: Introductionmentioning

confidence: 99%

Serum amylase and tissue polypeptide antigen as biochemical indicators of salivary gland injury during iodine-131 therapy

et al. 1994

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The study evaluated the possibility of using serum alpha-amylase and tissue polypeptide antigen (TPA) as biochemical markers of radiation injury in the salivary gland of patients with thyroid carcinoma treated with iodine-131. The results demonstrated that the two molecules increased 1 day after 131I administration and returned to near control values on the 3rd day. The increase was greater and longer lasting in those patients treated with the higher 131I administered activity. However, when the patients were divided into groups based on recovery time, which determined patients with different radionuclide elimination rates, the increase in the two molecules was greater and more lasting in those subjects with a longer period of hospitalization. A comparison with the values obtained from patients with tumours of the head and neck treated with external radiotherapy demonstrated that after the 1st day of treatment the salivary gland received an absorbed dose which, based on alpha-amylase levels, ranged between 0.24 and 1.89 Gy and, based on TPA levels, between 0.28 and 2.29 Gy.

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Section: Introductionmentioning

confidence: 99%

Serum amylase and tissue polypeptide antigen as biochemical indicators of salivary gland injury during iodine-131 therapy

et al. 1994

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Marker Determination for Response Monitoring: Radiotherapy and Disappearance Curves

1994

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This paper reports the results of studies on the possible role of biochemical markers in monitoring the effects of ionizing radiations and in the follow-up of cancer patients submitted to radiotherapy. Three different case series were analyzed: patients with head and neck cancer, prostate carcinoma and residual thyroid tumors or uptaking metastases (131-Iodine therapy). Serum TPA and amylase were serially determined in patients with head and neck or thyroid cancer to measure the radiation damage to the salivary glands. In the former group a statistically significant correlation between the increase of both molecules and the total dose administered after the first day of treatment (2, 3, 4 or 6 Gy) was observed. In patients treated for thyroid cancer the damage to the salivary glands was revealed by an increase in TPA and amylase serum levels, dependent on the dose of 131-Iodine administered. Moreover, an association was demonstrated between pretreatment values of TPA in patients with head and neck tumors and prognosis: patients with values below the cutoff have significantly higher survival rates than those with higher values. In patients with prostate carcinoma PSA was confirmed to have better diagnostic and prognostic value than PAP. Patients with metastases show an inversion or lack of negative trend in PSA levels observed in the disease-free patients. This precedes the clinical diagnosis of metastases by 1 to 15 months.

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Prospective Study of a Panel of Tumor Markers as Prognostic Factors in Patients with Squamous Cell Carcinoma of Head and Neck

Kandiloros

Eleftheriadou

Chalastras

et al. 2006

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Prognostic Significance of Tissue Polypeptide Antigen (TPA) in Head and Neck Carcinomas

Cited by 4 publications

References 11 publications

Serum amylase and tissue polypeptide antigen as biochemical indicators of salivary gland injury during iodine-131 therapy

Serum amylase and tissue polypeptide antigen as biochemical indicators of salivary gland injury during iodine-131 therapy

Marker Determination for Response Monitoring: Radiotherapy and Disappearance Curves

Prospective Study of a Panel of Tumor Markers as Prognostic Factors in Patients with Squamous Cell Carcinoma of Head and Neck

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