Abstract. Resistivity measurements were carried out up to 8 GPa on single crystal and polycrystalline samples of CeCu 2 Si 2 from differing sources in the homogeneity range. The anisotropic response to current direction and small uniaxial stresses was explored, taking advantage of the quasi-hydrostatic environment of the Bridgman anvil cell. It was found that both the superconducting transition temperature T c and the normal state properties are very sensitive to uniaxial stress, which leads to a shift of the valence instability pressure P v and a small but significant change in T c for different orientations with respect to the tetragonal c-axis. Coexistence of superconductivity and residual resistivity close to the Ioffe-Regel limit around 5GPa provides a compelling argument for the existence of a valence-fluctuation mediated pairing interaction at high pressure in CeCu 2 Si 2 .