Relation between male breast cancer and prostate cancer

Sobin, L H; Sherif, Mohamed H.

doi:10.1038/bjc.1980.313

Cited by 20 publications

(6 citation statements)

References 8 publications

(7 reference statements)

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“…Most authors found no association of prostatic cancer and breast cancer (Keller, 1967;Mabuchi et al, 1985;Schottenfeld et al, 1963). In contrast, in studies other than case-control studies, several investigators have mentioned a possible association between prostate cancer and male breast cancer (Choudhury et al, 1982;Marger et al, 1975;Schlappack et al, 1986;Sobin and Sherif, 1980). Sobin and Sherif (1980) found a worldwide correlation between the incidence of these 2 tumours, and this is confirmed in our data.…”

Section: Analytical Epidemiologysupporting

confidence: 85%

“…In contrast, in studies other than case-control studies, several investigators have mentioned a possible association between prostate cancer and male breast cancer (Choudhury et al, 1982;Marger et al, 1975;Schlappack et al, 1986;Sobin and Sherif, 1980). Sobin and Sherif (1980) found a worldwide correlation between the incidence of these 2 tumours, and this is confirmed in our data. Oestrogen therapy has been widely used for the treatment of prostate cancer and could lead to an increased risk of breast cancer.…”

Section: Analytical Epidemiologysupporting

confidence: 83%

See 1 more Smart Citation

Review article: Epidemiology of male breast cancer. A meta‐analysis of published case‐control studies and discussion of selected aetiological factors

Sasco

Lowenfels

Jong

1993

Intl Journal of Cancer

339

206

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Male breast cancer is a rare tumour in all parts of the world. About 1% of all breast cancers occur in men, but the male/female ratio is higher among black than among white populations. This effect can be seen in US cancer registries and even more markedly in African data. A positive correlation exists on a population scale between male breast cancer and prostate cancer. Seven case-control studies of male breast cancer are available, and a pooled analysis was conducted of the most commonly suspected risk factors. Male breast cancer appears to be associated with marital status: Mantel-Haenszel exposure odds ratio (EOR) for never married = 1.6; 95% confidence limits (CL) = 1.1, 2.3, religion (EOR for being Jewish = 2.1; 95% CL = 1.4, 3.2), previous breast pathology (EOR for positive history of benign breast disease = 2.7; 95% CL = 1.7, 4.2), gynaecomastia (EOR for positive history = 6.2, 95% CL = 3.4, 11.4), previous testicular pathology (EOR for positive history = 2.2; 95% CL = 1.5, 3.3), previous liver diseases (EOR for positive history = 1.6; 95% CL = 1.0, 2.4) and family history of breast cancer (EOR for first-degree relative with breast cancer = 2.5; 95% CL = 1.7, 3.7). No association is found with smoking history. Other potential risk factors such as reproductive history, education, occupation, anthropometric variables, association with various diseases, and specific exposures such as drug use, were not systematically evaluated in all studies and provide sometimes contradictory results, possibly due to small numbers of exposed subjects. Overall, the analytical epidemiology of male breast cancer presents similarities with the epidemiology of female breast cancer, with a potential role of factors related to hormonal status, relative hyperoestrogeny in men being potentially linked to increased risk of disease. Genetics may also play a role, with high risk linked to a familial history of breast cancer, and with a major risk in patients with Klinefelter's syndrome.

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Section: Analytical Epidemiologysupporting

confidence: 85%

Section: Analytical Epidemiologysupporting

confidence: 83%

Review article: Epidemiology of male breast cancer. A meta‐analysis of published case‐control studies and discussion of selected aetiological factors

Sasco

Lowenfels

Jong

1993

Intl Journal of Cancer

339

206

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“…Epidemiologic studies of breast cancer in men are difficult due to the rareness of the disease; however, BRCA2 mutations, family history of male breast cancer, Klinefelter syndrome, testicular disorders, radiation exposure, obesity and exogenous estrogen exposures are risk factors [11]. Increased risk of breast cancer after treatment for prostate cancer, possibly due to the use of hormonal therapies, has also been noted [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Secondary cancers after a lung carcinoid primary: A population-based analysis

et al. 2006

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“…11 However, although the risk factors appear to be the opposite for these two diseases, an epidemiologic study showed a direct rather than an inverse relationship between the incidence of prostate cancer and breast cancer in populations groups. 12 We sought to consider the potential relationship of these two diseases by evaluation of patients at our institution with the rare diagnosis of male breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Incidence of prostate cancer in male breast cancer patients: a risk factor for prostate cancer screening

Lee

Jones

2008

Prostate Cancer Prostatic Dis

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Synchronous or metachronous occurrences of both prostate cancer and male breast cancer are rarely reported, but provide insight into their hormonal and genetic biology. We sought to determine the incidence of prostate cancer in male breast cancer patients at our institution, and to examine estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu receptor (HR) status in these patients. A retrospective review was conducted of male breast cancer patients from 1990 to 2006. Histopathologic characteristics and hormone receptor expression was obtained. In 69 patients with male breast cancer, 12 (17%) also had a diagnosis of prostate cancer. Nine had ER-positive status and three were unreported. PR status was positive in 5, whereas 3 had PR-negative status. HR status was positive in 1, whereas 5 had HR-negative status. Male breast cancer patients in this cohort have an incidence of prostate cancer higher than would be predicted in the general population; this risk factor has implications for careful prostate cancer screening.

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Relation between male breast cancer and prostate cancer

Cited by 20 publications

References 8 publications

Review article: Epidemiology of male breast cancer. A meta‐analysis of published case‐control studies and discussion of selected aetiological factors

Review article: Epidemiology of male breast cancer. A meta‐analysis of published case‐control studies and discussion of selected aetiological factors

Secondary cancers after a lung carcinoid primary: A population-based analysis

Incidence of prostate cancer in male breast cancer patients: a risk factor for prostate cancer screening

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