Secondary cancers after a lung carcinoid primary: A population-based analysis

Coté, Michele L.; Wenzlaff, Angela S.; Philip, P. A.; Schwartz, Ann G.

doi:10.1016/j.lungcan.2006.02.004

Cited by 16 publications

(11 citation statements)

References 22 publications

(19 reference statements)

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“…These authors also reported on increased risks of breast and prostate cancer in males who had an earlier diagnosis of a lung carcinoid. In these studies, other types of second primary malignancies in lung carcinoid patients were not more prevalent than in the general population (Cote et al 2006).…”

Section: Endocrine-related Cancer (2012) 19 95-99mentioning

confidence: 67%

“…However, after that period, the risk of breast cancer was lower than expected (Cote et al 2006). These authors also reported on increased risks of breast and prostate cancer in males who had an earlier diagnosis of a lung carcinoid.…”

Section: Endocrine-related Cancer (2012) 19 95-99mentioning

confidence: 82%

“…In a study with a similar design in patients with primary lung carcinoids, Cote et al (2006) reported an increased risk of breast cancer in females within the first 5 years after the diagnosis of the lung carcinoid. However, after that period, the risk of breast cancer was lower than expected (Cote et al 2006).…”

Section: Endocrine-related Cancer (2012) 19 95-99mentioning

confidence: 99%

“…Therefore, we have conducted an analysis in this group of patients, using the same methodology as the study in patients with lung carcinoids (Cote et al 2006). Our methodology was also similar to the methodologies used in two large studies analyzing second primary cancer risks in patients with Merkel cell carcinomas, which are neuroendocrine skin tumors (Kaae et al 2010, Bzhalava et al 2011).…”

Section: Endocrine-related Cancer (2012) 19 95-99mentioning

confidence: 99%

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Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract and pancreas

Kamp¹,

Damhuis²,

Feelders³

et al. 2011

Endocrine-Related Cancer

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An increased association between neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NET) and other second primary malignancies has been suggested. We determined whether there is indeed an increased risk for second primary malignancies in GEP-NET patients compared with an age-and sex-matched control group of patients with identical malignancies. The series comprised 243 men and 216 women, diagnosed with a GEP-NET between 2000 and 2009 in a tertiary referral center. The timeline, before-at-after diagnosis, and the type of other malignancies were studied using person-year methodology. Poisson distributions were used for testing statistical significance. All data were cross-checked with the Dutch National Cancer Registry. Out of 459 patients with GEP-NET, 67 (13.7%) had a second primary cancer diagnosis: 25 previous cancers (5.4%), 13 synchronous cancers (2.8%), and 29 metachronous cancers (6.3%). The most common types of second primary cancer were breast cancer (nZ10), colorectal cancer (nZ8), melanoma (nZ6), and prostate cancer (nZ5). The number of patients with a cancer history was lower than expected, although not significant (nZ25 vs nZ34.5). The diagnosis of synchronous cancers, mainly colorectal tumors, was higher than expected (nZ13 vs nZ6.1, P!0.05). Metachronous tumors occurred as frequent as expected (nZ29 vs nZ25.2, NS). In conclusion, our results are in contrast to previous studies and demonstrate that only the occurrence of synchronous second primary malignancies, mainly colorectal cancers, is increased in GEP-NET patients compared with the general population.

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Section: Endocrine-related Cancer (2012) 19 95-99mentioning

confidence: 67%

Section: Endocrine-related Cancer (2012) 19 95-99mentioning

confidence: 82%

Section: Endocrine-related Cancer (2012) 19 95-99mentioning

confidence: 99%

Section: Endocrine-related Cancer (2012) 19 95-99mentioning

confidence: 99%

See 2 more Smart Citations

Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract and pancreas

Kamp¹,

Damhuis²,

Feelders³

et al. 2011

Endocrine-Related Cancer

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“…In the latter case, MEN-1 syndrome was diagnosed and genetically confirmed. According to American epidemiological research, the presence of bronchopulmonary carcinoid increases the risk of hormonally dependent neoplasms, including breast and prostate cancer, within a given population [18]. This can be explained by the role of genetic and hormonal factors, which are important in relation to bronchopulmonary carcinoid and are still subject to research.…”

Section: Discussionmentioning

confidence: 99%

THORACIC SURGERY Results of the surgical treatment of patients suffering from bronchopulmonary carcinoid tumors in the Department of Thoracic Surgery in Bystra in the period 1990-2011

Wiencek-Weiss¹,

Wandzel²,

Rogoziński³

et al. 2013

kitp

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Background: The new classification and terminology concerning neuroendocrine tumors, according to the European Neuroendocrine Tumor Society (ENETS) guidelines, were not universally accepted for bronchopulmonary carcinoids. That is why the term "carcinoid" is still being used in its traditional meaning. Precise identification of bronchopulmonary carcinoid subtypes constitutes an important prognostic factor. Aim of the study: The aim of the study was to present the results of bronchopulmonary carcinoid surgical treatment conducted at the Department of Thoracic Surgery in Bystra, to assess the surgery material in accordance with the WHO 1999 (Travis) classification, and to compare the clinical courses of typical and atypical carcinoid tumors. Material and methods: The analysis included 159 patients aged 18-77, treated surgically due to bronchopulmonary carcinoids in the years 1990-2011. Reassessment of histological preparations was carried out according to the WHO 1999 (Travis) and International Association for the Study of Lung Cancer (IASLC) classification; check-ups of the treated patients were performed as well. Disease-free interval (DFI) and overall survival were assessed with the Kaplan-Meier method; the clinical course of typical and atypical carcinoids was compared. Results: As a result of the histological reassessment, 142 patients (88.3%) were diagnosed with typical carcinoids, and 17 patients (11.7%) with atypical carcinoids. During the followup period, local disease recurrence occurred in 8 (4.9%) patients, distant metastases in 13 (8.2%) patients. There were 26 (16.4%) instances of death -2 because of other malignant neoplasms. The DFI median (p = 0.00003) and overall survival (p < 0.00001) were significantly longer in patients with typical carcinoids than in patients with atypical types of the tumor. Conclusions: The histological subtype of a bronchopulmonary carcinoid tumor is the dominant prognostic factor in assessing the DFI and the 5-year survival after surgery. Key words: typical carcinoid, atypical carcinoid, neuroendocrine tumors. StreszczenieWstęp: Wprowadzona nowa klasyfikacja i terminologia guzów neuroendokrynnych zgodnie z wytycznymi European Neuroendocrine Tumor Society (ENETS) nie została powszechnie przyjęta w odniesieniu do rakowiaka oskrzelowo-płucnego i nadal używa się określenia "rakowiak" w tradycyjnym ujęciu. Dokładna identyfikacja podtypu rakowiaka oskrzelowo-płucnego ma istotne znaczenie dla rokowania. Cel pracy: Przedstawienie wyników leczenia operacyjnego rakowiaka oskrzelowo-płucnego na Oddziale Chirurgii Klatki Piersiowej w Bystrej, ocena histologiczna materiału operacyjnego zgodnie z klasyfikacją WHO 1999 -Travisa, a także porównanie przebiegu klinicznego rakowiaka typowego i atypowego. Materiał i metody: Analizie poddano 159 chorych w wieku 18-77 lat operowanych z powodu rakowiaka oskrzelowo-płucnego w latach 1990-2011. Przeprowadzono ponowną ocenę preparatów histologicznych na podstawie materiału archiwalnego zgodnie z klasyfikacją WHO 1999 -Travis i IASCL oraz b...

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Bronchopulmonary neuroendocrine tumors

Gustafsson

Kidd

Chan

et al. 2008

Cancer

444

340

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SCLC is the most common BP-NET, while LCNEC is rare, %10% and 1%, respectively, of all lung cancers. Both SCLC and LCNEC progress rapidly, are aggressively metastatic, and exhibit a poor prognosis. The incidence of BP-carcinoids (TC and AC) in the US was 1.57 of 100,000 in 2003 (an unexplained and substantial increase over the last 30 years, %6% per year). No curative treatment except for radical surgery (almost never feasible) exists. The slow-growing TC exhibit a fairly good prognosis (%88%, 5-year survival), whereas AC demonstrate a 5-year survival of %50%, and the highly malignant LCNEC and SCLC 5-year survival of 15% to 57% and <5%, respectively. This review provides a broad overview on BPNETs and focuses on the evolution of the disease, general features, and current diagnostic and therapeutic options.

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Secondary cancers after a lung carcinoid primary: A population-based analysis

Cited by 16 publications

References 22 publications

Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract and pancreas

Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract and pancreas

THORACIC SURGERY Results of the surgical treatment of patients suffering from bronchopulmonary carcinoid tumors in the Department of Thoracic Surgery in Bystra in the period 1990-2011

Bronchopulmonary neuroendocrine tumors

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