Relation between heart rate and QT interval in exercise-induced myocardial ischemia

Romanò, Massimo; Maro, T. Di; Carella, G; Cotecchia, M R; Ferrò, Giuseppe; Chiariello, Massimo

doi:10.1016/0002-9149(85)90770-2

Cited by 27 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reason for these findings is complex because not all individuals with hypertension exhibit increased catecholamine synthesis and release, nor are they as sensitive to the effects of catecholamines on the heart. 55,56 Changes in QT interval duration secondary to acute alterations in BP In experimental hypertension, elevated BP correlates with QT prolongation independent of associated LVM. 3 This finding suggests that ventricular loading may affect ventricular repolarization.…”

Section: The Mechanisms Underlying the Effect Of Hypertension On The mentioning

confidence: 99%

Modulation of the QT interval duration in hypertension with antihypertensive treatment

2015

View full text Add to dashboard Cite

The duration of the QT interval as measured by 12-lead electrocardiography is a measure of myocardial repolarization and is widely used to describe cardiac abnormalities, to determine the presence of cardiac toxicity and to evaluate drug safety. In hypertension, the QT interval is a predictor of the risk of both coronary events and cardiovascular death, after adjusting for the effects of additional risk factors. The mechanism of QT interval prolongation is multifactorial and includes cardiomyocyte hypertrophy and increased left ventricular mass, with accompanying changes in left ventricular transmural dispersion of repolarization, as well as changes in the tone of the autonomic nervous system of some patients with hypertension and mechano-electrical feedback, although this mechanism is less likely. Antihypertensive drugs vary in their effect on QT interval duration. The mechanisms underlying their effect depend on changes in left ventricular mass and autonomic nervous system tone, as well as changes in the activity of cardiac ion channels. Although blood pressure reduction is the primary goal of antihypertensive drug therapy and although the choice of antihypertensive drug treatment regimens varies among different individuals, the data regarding the disparate effects of antihypertensive drugs on the duration of the QT interval warrant consideration when implementing long-term pharmacotherapy for hypertension.

show abstract

Section: The Mechanisms Underlying the Effect Of Hypertension On The mentioning

confidence: 99%

Modulation of the QT interval duration in hypertension with antihypertensive treatment

2015

View full text Add to dashboard Cite

show abstract

“…Our group has a thorough knowledge of manual QT calculation, as described previously [7,13,14], At present we use the computer ized system at our Institute because of simplification in procedures. The resting recording and time wave calculation, however, by com puter, in our opinion, is more accurate than manual calculation.…”

Section: Methodsmentioning

confidence: 99%

Correcting the QT Interval for Heart Rate by a Simple Linear Regression Formula: Applicability in Clinical Practice

Romano¹,

Adinolfi²,

Cotecchia³

et al. 1987

Am J Noninvas Cardiol

Self Cite

View full text Add to dashboard Cite

Several studies investigated the human heart rate (HR)-QT interval relationship using different formulae, but in clinical use the necessity of a simple means of correction is apparent. We assessed the resting supine HR-QT relation in health nonhospitalized subjects (age range 20-60 years, 494 men and 536 women) undergoing noninvasive diagnostic examination, and patients with a history or evidence of heart disease were excluded. The electrocardiographic data were recorded and calculated by a Marquette computer-assisted system (QT as mean of all standard leads). A linear relationship was found between the HR and QT interval in males and females, as follows: males (n = 494), QT - 524 ms, 2.05 HR, r = -0.85; females (n = 536), QT = 515 ms, 1.88 HR, r = -0.80. The correlation coefficients are highly significant in both cases (p < 0.001). The use of curvilinear regression formulae permits quite similar correlation coefficients. The present results show that over the resting range of HR, in subjects without heart disease, a linear relationship exists between HR and QT interval and a rate-corrected ‘index’ value can be easily calculated in clinical use.

show abstract

“…It was demonstrated that the prolongation of QT interval or QT dispersion is associated with prior myocardial infarction or coronary artery disease under not only resting state [1,2], but also physical exercise [3,4], atrial pacing exercise [5] or pharmacological stress [6], and that QT dispersion is related to the effects after successful thrombolysis in infarctrelated myocardium [7], or to the extent of viable but infarctrelated myocardium [8]. On the other hand, after the acute phase of myocardial infarction, the important factor that affects the long-term survival is the condition of the viable infarct-related myocardium including myocardial scar, which can be estimated by exercise thallium-201 single photon emission computed tomography (SPECT) [9][10][11] We hypothesized that the change with exercise in QT dispersion also reflects the results of exercise perfusion SPECT in the infarct-related myocardium after angioplasty.…”

Section: Introductionmentioning

confidence: 99%

Change with exercise in QT dispersion in infarct-related myocardium after angioplasty

Akutsu

Shinozuka

et al. 2005

International Journal of Cardiology

View full text Add to dashboard Cite

Relation between heart rate and QT interval in exercise-induced myocardial ischemia

Cited by 27 publications

References 12 publications

Modulation of the QT interval duration in hypertension with antihypertensive treatment

Modulation of the QT interval duration in hypertension with antihypertensive treatment

Correcting the QT Interval for Heart Rate by a Simple Linear Regression Formula: Applicability in Clinical Practice

Change with exercise in QT dispersion in infarct-related myocardium after angioplasty

Contact Info

Product

Resources

About