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inimary:The assessment of chronic phannacological atnient of stable angina requires serial exercise stress ;rings. It is well known that exercise tolerance can be ,proved by the training effect of performing repeated ;tings. Our study investigated the values of heart rate, stolic blood pressure, rate-pressure product, and duratn of exercise at 0.1 mV ST depression during exercise d the same parameters plus the maximal ST-segment pression at peak exercise, collected from three differt tests. The first and second werc performed at one-week ervals before, and the third (75 days after the first), was rformed after a double-blind study with a drug versus tcebo. We found a significant increase of exercise duion at 0.1 mV ST depression and at peak exercise, while if 12 patients increased exercise duration from the send to the third test. Individual variability of exercise ration showed increasing values, ranging from 0 to 7 1 % rst vs. third test). In contrast, the ratio of heart rate and rtolic blood pressure did not differ between the tests. ir data criticized the use of mean values of exercise time -phamiacological studies; moreover, individual variaity could affect results independently of drug or placebo ministration. These findings should be taken into acunt in order to exclude misleading results. . dc Arcangelis is presently a medical student.

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