“…Tophaceous deposits tend to occur in various tissues in patients with long maintained hyperuricemia, and joint destruction or nephropathy, or both, develop insidiously over the course of years (78,172). In unusual instances the disease may mimic rheumatoid arthritis (45,69,165) ; it may be associated with diabetes mellitus (17,223), cystinuria (149), arterial hy pertension (24,28) ; or it may produce necrosis of the head of the femurs (93,140), sacroiliac arthritis (146), or carpal tunnel nerve compression (164). Aminoaciduria (101) and impaired excretion of bromsulphthalein dye (188) are interesting additional anomalies in patients with gout.…”