Weekly treatment with low-dose oral methotrexate (MTX) was compared with daily auranofin (AUR) treatment in a 36-week double-blind, randomized, multicenter study of 281 patients with active, adult-onset rheumatoid arthritis. Both treatment groups showed significant improvement by the usual measures of clinical efficacy. The response with MTX occurred earlier and was consistently greater than that with AUR. An intent-to-treat analysis showed significantly greater improvement (P < 0.01) with MTX for painful and swollen joint counts and physician and patient global assessments of disease activity. Adverse reactions were reported more frequently in the AUR group, and more AUR-treated patients were withdrawn from the study because of toxicity. MTX was thus more effective and better tolerated than AUR in this study.
With the technical assistance of N . €I. CurryFourteen (4 per cent) of 340 blood donors showed the presence of rheumatoid factor and some of these were studied in detail. One young donor with very high titers of rheumatoid factor and a 22s component, followed for over two years, has shown no clinical evidence of disease. The sensitized human cell test compares favorably with latex reagent. Both methods are more sensitive and less specific than the sensitized sheep cell test.Inter 340 donatores de sanguine, 14 (i.e. 4 pro cento) monstrava le presentia de factor rheumatoide, e plures de istes esseva studiate in detalio. Un juvene donator con altissime titros de factor rheumatoide e un componente 22s monstrava nulle sign0 de morbo durante plus que duo annos de abservation. Le test a sensibilisate cellulas human es nullemente minus bon que le test a latex. Ambe iste tests es plus sensibile e minus specific que le test a sensibilisate cellulas ovin.
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