The L.E. Cell in Rheumatoid Arthritis

Toone, Elam C.; Irby, Robert; Pierce, Edwin L.

doi:10.1097/00000441-196011000-00008

Cited by 28 publications

(8 citation statements)

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“…First description of RHUPUS was done by Toone in 1960 [8]. In SLE, joint involvement may range from minor joint pain to severe deforming arthritis as well as Jaccoud's arthropathy, but sometimes joint pain is more severe than joint objective findings [13–15].…”

Section: Discussionmentioning

confidence: 99%

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RHUPUS Syndrome in Children: A Case Series and Literature Review

Ziaee

Moradinejad

Bayat

2013

Case Reports in Rheumatology

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Objective. Overlap of juvenile idiopathic arthritis (JIA) and juvenile systemic lupus erythematosus (JSLE) is a rare clinical condition in children. This condition has been described as RHUPUS syndrome. Prevalence of this syndrome and 3 cases are reported in this paper. Cases Presentation. During 10 years, 3 patients with SLE had chronic arthritis before or after diagnosis of SLE. Prevalence of this disorder in JSLE was 2.5%. Two patients were females and one of them was a male. According to our review, mean delay between chronic joint involvement and JSLE diagnosis was 50.1 months. In our case report, two females had joint erosion and one of them died due to heart failure, but in the literature review, just 45% cases had joint erosion and 70% cases were polyarticulare form. Conclusion. RHUPUS is unusual presentation of lupus in children. It seems that clinical feature and outcome of RHUPUS syndrome are different in children due to difference between RA and JIA. We suggest juvenile RHUPUS for overlap of JIA and JSLE.

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Section: Discussionmentioning

confidence: 99%

“…For the first time, RHUPUS syndrome was described by Schur in 1971 [7], but first clinical observation of this syndrome has been described in 1960 by Toone. He identified this clinical manifestation with this entity [8]. …”

Section: Introductionmentioning

confidence: 99%

RHUPUS Syndrome in Children: A Case Series and Literature Review

Ziaee

Moradinejad

Bayat

2013

Case Reports in Rheumatology

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“…It is the experience of most rheumatologists that at the outset there may be several features characteristic of more than one rheumatic disease, or sometimes during the course of the disease, there may be a progression of one rheumatic disease syndrome into another. Such 'overlap' syndromes have been described for scleroderma and dermatomyositis (Tuffanelli and Winkelmann et al, 1961;Clark et al, 1971), rheumatoid arthritis and scleroderma (Tuffanelli and Winkelmann et al, 1961;Poirer and Rankin, 1972), SLE and polymyositis (Keil, 1940;Estes and Christian, 1971;Dubois, 1973), rheumatoid arthritis and SLE (Haserick, 1955;Sigler et al, 1958;Toone et al, 1960;Dubois 1962;Dubois, 1974), and scleroderma and SLE (Muehrcke et al, 1957;Tuffanelli and Winkelmann, 1961;Rowell, 1962;D'Angelo et al, 1969;Dubois, et al, 1971;Poirer and Rankin, 1972;Dubois, 1974). Whether such associations represent the co-existence of separate diseases, distinct clinical entities, or the more widespread expression of a single rheumatic disease syndrome, has been a source of some controversy.…”

Section: Discussionmentioning

confidence: 97%

The arthritis of mixed connective tissue disease.

Bennett¹,

O'Connell²

1978

Annals of the Rheumatic Diseases

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SUMMARY Twenty patients with mixed connective tissue disease were followed for 5 years. Arthritis occuured in all 20 patients, being the presenting complaint in 11 patients. The joints most frequently involved were the proximal interphalangeal (PIP), metacarpophalangeal (MCP), wrists, metatarsophalangeal (MTP), and knee; the distribution tended to be symmetrical, mimicking early rheumatoid arthritis. Joint deformities occurred in 6 patients, but apart from 1 patient with arthritis mutilans, significant functional impairment was not encountered. Radiologically small punched out bone erosions, asymmetrically distributed, were the most characteristic finding; other notable changes were aseptic necrosis, tuft erosions, and periarticular calcification. Joint effusions were noninflammatory, the cellular content was predominantly lymphocytic and the C3 level was normal. Most cases were controlled with non-steroidal anti-inflammatory agents and invariably responded to prednisone .7 * 5 mg/day.

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“…The first insights about the RA and SLE overlap come from 1960, when Toone and colleagues described the presence of LE cells (until then, considered as exclusive for SLE) in sera of 15 patients with RA, 8 of them with systemic manifestations 8 . Several following studies showed positive rheumatoid factor in almost all rhupus patients 2,3,6,7 .…”

Section: Do These Clinical Manifestations and Autoantibodies Revealmentioning

confidence: 99%

Overlap Between Systemic Lupus Erythematosus and Rheumatoid Arthritis: Is It Real or Just an Illusion?

Amezcua-Guerra¹

2009

J Rheumatol

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The L.E. Cell in Rheumatoid Arthritis

Cited by 28 publications

References 0 publications

RHUPUS Syndrome in Children: A Case Series and Literature Review

RHUPUS Syndrome in Children: A Case Series and Literature Review

The arthritis of mixed connective tissue disease.

Overlap Between Systemic Lupus Erythematosus and Rheumatoid Arthritis: Is It Real or Just an Illusion?

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