Report of Two Cases With an Immunopathological Review

Gange, Richard W.

doi:10.1111/j.1365-2230.1976.tb01428.x

Cited by 19 publications

(7 citation statements)

References 21 publications

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“…Electron-dense deposits were found near the surface ofchondrocytes that corresponded with the location of immunofluorescence using antisera to rat IgG and C3 . This finding was of interest because both IgG and C3 have been demonstrated in the cartilage of patients with relapsing polychondritis (11)(12)(13) . Further, as in human disease (3), IgG antibody to native type II collagen was found in the sera of rats with active chondritis .…”

Section: Discussionmentioning

confidence: 88%

Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.

Cremer¹,

Pitcock²,

Stuart³

et al. 1981

The Journal of Experimental Medicine

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Relapsing polychondritis is an inflammatory disease of connective tissue characterized by the destruction of hyaline and elastic cartilages . Although the etiology of this disease is unknown, the demonstration of anti-cartilage antibodies in the sera of patients with this disorder suggests an autoimmune mechanism (1, 2) . Recently, Foidart et al . (3) have reported an association between relapsing polychondritis and autoimmunity to type II collagen, the major collagen type in cartilage . This finding was of particular interest because we (4) and others (5, 6) have reported that rats and mice (7), after sensitization with purified native type II collagen, developed inflammatory polyarthritis that was closely associated with an intense immune response to type II collagen (4-6) .We have recently discovered that some rats sensitized with type II collagen also develop inflammatory ear lesions (8) characterized by an intense, destructive chondritis resembling the histopathologic process seen in human relapsing polychondritis .Described here are our findings, which closely associate the presence of these experimental lesions with the immune response to native type II collagen . These observations suggest that collagen-induced chondritis in rats might serve as an experimental model for human relapsing polychondritis . Materials and MethodsAnimals . Outbred female Wistar and inbred Wistar-Lewis rats weighing 100-125 g were obtained from the Charles River Breeding Laboratories, Inc ., Wilmington, Mass . and fed laboratory chow and water ad libitum . Wistar-Lewis rats were provided through the courtesy of the National Cancer Institute.Preparation of Collagen . Native bovine and rat type II collagens were solubilized by limited pepsin digestion of fetal calf cartilage and a rat chondrosarcoma tumor, respectively, and purified as described in a previous report (4) . The rat chondrosarcoma tumor was a gift from Dr. George Martin of the National Institute of Dental Research . The purity of these collagens was determined by amino acid analysis, sodium dodecyl sulfate polyacrylamide gel electrophoresis, and uronic acid analysis .

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Section: Discussionmentioning

confidence: 88%

Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.

Cremer¹,

Pitcock²,

Stuart³

et al. 1981

The Journal of Experimental Medicine

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“…Based on the detected deviations in autoantibodies against collagen type II, IX and XI, matriline-1 and COMP and the cell-mediated immunity with increased expression of INF-γ, IL2, IL12, MMP-3, 8, 9, cathepsins K and L as well as in the secretion of cytokines by CD4+ cells activating leukocytes, the most likely hypothesis for pathogenesis of the disease is that triggering factors, such as infectious agents, drugs, chemicals, toxins or direct trauma, provoke protein degranulation and cause the release of specific antigens against cartilage structures [5,10,18,[23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…PR is characterized by multisystemic involvement, hence, the main manifestation with primary diagnostic value is chondritis with sequential or simultaneous involvement of several cartilage organs [1,2,5,[6][7][8][9][10][11]18]. The cartilage of the outer ear and nose is most often affected, 80-90% and 50-70% of cases, respectively [1,2,[6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…PR can also affect organs that do not contain cartilage tissue. Ocular changes occur in 20% to 60% of patients with PR [2,7,18,29]. Usually conjunctivitis, episcleritis, scleritis, uveitis, iritis, chorioretinitis or dry keratoconjunctivitis and keratitis are seen.…”

Section: Discussionmentioning

confidence: 99%

“…The cardiovascular system is damaged in about 30% of patients [2,7,18,31]. The heart valves with manifestations of both stenosis and insufficiency are affected.…”

Section: Discussionmentioning

confidence: 99%

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Polychondritis Recidivans – A Case Report with a Review of the Literature

Yungareva,

Broshtilova,

Trenovski

et al. 2023

IJCD

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Polychondritis recidivans is a rare immune-mediated autoimmune, multisystemic disease. It proceeds with recurrent inflammation of both cartilage tissue, mainly the ears, nose, larynx, tracheobronchial tree, ribs and joints, as well as the proteoglycan-rich tissues of the heart valves, blood vessels and eyes. The clinical picture is diverse. Symptoms often overlap with other diseases and diagnosis is delayed. Late diagnosis is the main cause of complications, and life-threatening damage to the affected structures. Polychondritis recidivans may be self-contained or associated with other autoimmune diseases, vasculitis, or hematological disorders. The diagnosis is clinical. The main manifestation of diagnostic value is chondritis with sequential or simultaneous involvement of several cartilage organs. There is no specific laboratory test for the disease. A cornerstone of therapy is glucocorticoids. With severe course, immunosuppressants are also used, and recently biological agents. We describe a case of a 51-year-old woman with repeated recurrences of moving inflammation of the ear cartilage, accompanied by arthritis, severely reduced hearing, hoarseness, conjunctivitis and episcleritis, and CNS symptoms. Blood tests showed leukocytosis and elevated C-reactive protein. Polychondritis recidivans is diagnosed based on the diagnostic criteria of L. P. McAdam et al., J. M. Damiani and H. L. Levine and C. J. Michet et al. Dramatic improvement from methylprednisolone treatment supported the diagnosis. An overview of the epidemiology, pathogenesis, clinical picture, complications, laboratory and imaging diagnostic methods, and treatment of polychondritis recidivans are presented.

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Disorders of Connective Tissue

Burrows¹,

Lovell²

2004

Rook's Textbook of Dermatology

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Report of Two Cases With an Immunopathological Review

Cited by 19 publications

References 21 publications

Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.

Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen.

Polychondritis Recidivans – A Case Report with a Review of the Literature

Disorders of Connective Tissue

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