Reinforcing, subjective, and psychomotor effects of sevoflurane and nitrous oxide in moderate‐drinking healthy volunteers

Zacny, James P.; Janiszewski, Debra; Sadeghi, Parvine; Black, Matthew L.

doi:10.1046/j.1360-0443.1999.941218177.x

Cited by 10 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the toxicity of many inhalants, these clinical studies have been by necessity limited to comparing between volatile and gas anesthetics but they are nonetheless informative. For instance it has been shown that the subjective ratings produced by nitrous oxide differ from those of isoflurane (Zacny et al 1994) and sevoflurane (Zacny et al 1999) but that isoflurane and sevoflurane were indistinguishable from each other (Beckman et al 2006). The authors suggested that the ability to differentiate between nitrous oxide and the volatile anesthetics was due to nitrous oxide producing NMDA antagonist effects that were not present in the volatile anesthetics vapors.…”

Section: Discussionmentioning

confidence: 99%

Discriminative stimulus effects of inhaled 1,1,1-trichloroethane in mice: comparison to other hydrocarbon vapors and volatile anesthetics

Shelton

2008

Psychopharmacology

View full text Add to dashboard Cite

Rationale-Because the toxicity of many inhalants precludes evaluation in humans, drug discrimination, an animal model of subjective effects, can be used to gain insights on their poorly understood abuse-related effects.Objectives-The purpose of the present study was to train a prototypic inhalant that has known abuse liability, 1,1,1-trichloroethane (TCE), as a discriminative stimulus in mice and compare it to other classes of inhalants.Methods-Eight B6SJLF1/J mice were trained to discriminate 10 min of exposure to 12000 ppm inhaled TCE vapor from air and seven mice were trained to discriminate 4000 ppm TCE from air. Tests were then conducted to characterize the discriminative stimulus of TCE and to compare it to representative aromatic and chlorinated hydrocarbon vapors, volatile halogenated anesthetics as well as an odorant compound.Results-Only the 12000 ppm TCE versus air discrimination group exhibited sufficient discrimination accuracy for substitution testing. TCE vapor concentration-and exposure timedependently substituted for the 12000 ppm TCE vapor training stimulus. Full substitution was produced by trichloroethylene, toluene, enflurane and sevoflurane. Varying degrees of partial substitution were produced by the other volatile test compounds. The odorant, 2-butanol, did not produce any substitution for TCE.Conclusions-The discriminative stimulus effects of TCE are shared fully or partially by chlorinated and aromatic hydrocarbons as well as by halogenated volatile anesthetics. However, these compounds can be differentiated from TCE both quantitatively and qualitatively. It appears that the degree of similarity is not solely a function of chemical classification but may also be dependent upon the neurochemical effects of the individual compounds.

show abstract

Section: Discussionmentioning

confidence: 99%

Discriminative stimulus effects of inhaled 1,1,1-trichloroethane in mice: comparison to other hydrocarbon vapors and volatile anesthetics

Shelton

2008

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Nitrous oxide is well known to be capable of abuse [7–10]. However, the volatile anaesthetics are not usually considered drugs of abuse although there are several reports indicating that they too have the capacity to be abused [11–13]. A recent survey of academic anaesthesia programmes that covered the years 1990–1996 reported five residents who had abused nitrous oxide and two residents who had abused halothane, but no other inhalational anaesthetics were reported as drugs that were abused in the survey period [1].…”

mentioning

confidence: 99%

“…A recent survey of academic anaesthesia programmes that covered the years 1990–1996 reported five residents who had abused nitrous oxide and two residents who had abused halothane, but no other inhalational anaesthetics were reported as drugs that were abused in the survey period [1]. Zacny has shown that nitrous oxide has reinforcing properties in healthy volunteers as well as moderate drinkers, although some of these reinforcing properties may be related to the subject being told they are inhaling nitrous oxide [7, 10, 13, 14]. In addition, Zacny has shown that the volatile anaesthetic sevoflurane has some reinforcing properties in moderate‐drinking healthy volunteers as well as healthy non‐drug abusers [12, 13].…”

mentioning

confidence: 99%

“…Zacny has shown that nitrous oxide has reinforcing properties in healthy volunteers as well as moderate drinkers, although some of these reinforcing properties may be related to the subject being told they are inhaling nitrous oxide [7, 10, 13, 14]. In addition, Zacny has shown that the volatile anaesthetic sevoflurane has some reinforcing properties in moderate‐drinking healthy volunteers as well as healthy non‐drug abusers [12, 13].…”

mentioning

confidence: 99%

See 1 more Smart Citation

A survey of inhalational anaesthetic abuse in anaesthesia training programmes*

et al. 2008

View full text Add to dashboard Cite

SummaryThis study aims to assess the prevalence and outcomes of inhalational anaesthetic abuse among anaesthesia training programmes. Online surveys were completed by chairpersons of academic anaesthesia training programmes in the United States. The response rate was 84% (106 ⁄ 126 programmes). Twenty-two percent of the departments had had at least one incident of inhalational anaesthetic abuse. Forty-eight percent (15 ⁄ 31) of the persons abusing inhalational anaesthetics were sent for rehabilitation. Only 22% (7 ⁄ 31) of those found to be abusing inhalational anaesthetics were ultimately able to return successfully to anaesthesia practice with sustained recovery. The mortality rate among individuals found abusing inhalational anaesthetics was 26% (8 ⁄ 31). The majority of the anaesthesia departments (97 ⁄ 104, 93%) did not have any pharmacy accounting of inhalational anaesthetics. This is the first published survey of inhalational anaesthesia abuse. Inhalational anaesthetic abuse should be considered in at-risk individuals or those with a history of substance abuse. The concern about substance abuse is not unique to American anaesthetists. Countries around the world deal with similar substance abuse issues.

show abstract

“…Furthermore, previous clinical studies showed that ketamine causes adverse side effects such as hallucinations and delusions 11 and propofol causes hypotension (low blood pressure). 9 Zacny and Janiszewski 12 conducted an interesting experimental study on moderate-drinking healthy volunteers to compare the reinforcing and subjective effects between sevoflurane and nitrous oxide. Their results showed that while nitrous oxide was chosen by 71% of the participants, sevoflurane did not function as a reinforcer in most of the participants.…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane augmentation in treatment-resistant depression: a clinical case study

Wang

Cheng

Feng

et al. 2020

Therapeutic Advances in Psychopharmacology

View full text Add to dashboard Cite

Compared with other inhaled anaesthetics, sevoflurane has a faster onset and offset, causes less irritation to the mucous membranes, and has a better safety profile. These characteristics warrant investigating the effect of sevoflurane in depression. In this Case Report, we describe that sevoflurane treatment was feasible and well tolerated by a patient with treatment-resistant depression (TRD). Sevoflurane had rapid and durable antidepressant effects, with few adverse effects. Moreover, the patient showed significant improvements in neurocognitive measurements. Our preliminary results suggest that further clinical trials are needed to determine the independent efficacy and safety of sevoflurane in patients with TRD.

show abstract

Reinforcing, subjective, and psychomotor effects of sevoflurane and nitrous oxide in moderate‐drinking healthy volunteers

Cited by 10 publications

References 0 publications

Discriminative stimulus effects of inhaled 1,1,1-trichloroethane in mice: comparison to other hydrocarbon vapors and volatile anesthetics

Discriminative stimulus effects of inhaled 1,1,1-trichloroethane in mice: comparison to other hydrocarbon vapors and volatile anesthetics

A survey of inhalational anaesthetic abuse in anaesthesia training programmes*

Sevoflurane augmentation in treatment-resistant depression: a clinical case study

Contact Info

Product

Resources

About