Regulatory B cells: Evidence, developmental origin and population diversity

A B-1a cell subset induces Foxp3− T cells with regulatory activity through an IL-10-independent pathway

“…Functional studies indicate that regulatory B cells can actively modulate immune responses through mechanisms involving cell-cell interactions and cytokine production, especially through IL-10. 7 With the ability to influence CD4 1 T cells through cytokine production and direct cell-cell interactions, whether B cells can promote the conversion of effector T cells into Treg cells has been discussed recently. In the past few years, several in vitro coculture experiments have shown that B cells have the ability to induce the generation of Treg cells and expand Foxp3 1 CD4 1 T cells in the absence of exogenous cytokines.…”

Regulatory B Cells and Allergy: Uncovering the Link

“…Adoptive transfer of this specific B-cell subset, which is derived from sensitized animals, proved to be effective in reducing inflammation in recipients sensitized with the same chemical, but not with a different one. Apparently, these data expose an underlying specificity in the Breg cell response in CHS [51,52].…”

“…CD19 expression is critical, and CD19 loss resulted in increased and prolonged reaction of CHS, suggesting an inhibitory role of CD19 expression in CHS [50]. Yanaba et al [51] reported the existence of a B-cell subset characterized by the phenotype CD19 , which is capable of suppressing experimental induced CHS in an antigen-restricted and IL-10-dependent manner [51,52]. Adoptive transfer of this specific B-cell subset, which is derived from sensitized animals, proved to be effective in reducing inflammation in recipients sensitized with the same chemical, but not with a different one.…”

Bregs in Chronic HBV: Is It Time for Bragging Rights?

“…These B cells are functionally defined ''regulatory B cells,'' or Breg, possibly acting earlier in the immune response than Treg cells [5]. Expansion of Bregs inhibits harmful immune responses to chronic inflammation by suppressing effector T cells, either through contactdependent or independent mechanisms [6]. The best understood mechanism by which Bregs suppress immune function is through secretion of IL-10, which inhibits the production of pro-inflammatory cytokines and supports regulatory T cell differentiation.…”