Regulation of the human lipoprotein lipase gene by the forkhead box transcription factor FOXA2/HNF-3β in hepatic cells

Kanaki, Maria; Kardassis, Dimitris

doi:10.1016/j.bbagrm.2017.01.007

Cited by 17 publications

(12 citation statements)

References 63 publications

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“…LPL (lipoprotein lipase) is the key enzyme of lipid metabolism and is involved in the hydrolysis of triacylglycerol-rich lipoproteins (TRLs) to release fatty acids ( 42 ). Liver LPL overexpression or deficiency has recently revealed glucose and lipid metabolic disorders in mice ( 43 ). SOD1 (superoxide dismutase 1) is commonly known for its reactive oxygen species (ROS) scavenging activity.…”

Section: Discussionmentioning

confidence: 99%

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Lactobacillus acidophilus LA14 Alleviates Liver Injury

Yao

Ren

et al. 2021

mSystems

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Section: Discussionmentioning

confidence: 99%

“…The serum levels of glycylproline dipeptidyl aminopeptidase, ALT, AST, ALP, cholinesterase, total bilirubin, total bile acids, direct bilirubin, total protein, and albumin were tested using a Hitachi 7600-210 automatic analyzer (Tokyo, Japan) ( 43 ).…”

Section: Methodsmentioning

confidence: 99%

Lactobacillus acidophilus LA14 Alleviates Liver Injury

Yao

Ren

et al. 2021

mSystems

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“…In the present study, the expressions of PPARγ and ATGL in adipose tissue were significantly upregulated in the BS15 group compared with the SNE group, which were supported by the previous verdicts that the lower abdominal fat in BS15 broilers than that in stricken chicks, although there was no obvious change of TG in serum. Researches proved that proper regulation of LPL is important for controlling the delivery of lipid nutrients to tissues (Davies et al 2012), and it plays a dominant role in the hydrolysis of TG (Kanaki and Kardassis 2017). The consequence in our study shown that the gene expression of LPL was downregulated in SNE-infected chicks with replenishing BS15, but not significantly, implying that BS15 could effectively inhibit the abdominal fat deposit.…”

Section: Discussionmentioning

confidence: 99%

Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens

et al. 2017

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Increasing studies have focused on the beneficial effects of Lactobacillus johnsonii in certain diseases. Here, we studied the prevention ability of a probiotic strain, L. johnsonii BS15 on subclinical necrotic enteritis (SNE), and its underlying mechanism. 180 male Cobb 500 chicks were randomly allotted into three groups and administrated with BS15 (1 × 106 cfu/g) or Man Rogosa Sharpe liquid medium throughout a 28-day experimental period. With the exception of the normal group, SNE infection was treated for the remaining experimental period after the chicks were fed with normal diet 14 days. Results showed that BS15 notably suppressed the SNE-induced loss of average daily gain and liver functional abnormality. Additionally, BS15 facilitated lipid metabolism of SNE boilers when the contents of peroxisome proliferator activated receptor γ and adipose triglyceride lipase in adipose tissue and serum high-density lipoprotein cholesterol decreased. BS15 also attenuated the hepatic lipid accumulation of stricken chicks by suppressing the genes expression of acetyl-CoA carboxylase, fatty acid synthase and sterol regulatory element binding protein-1c as well as stimulating the genes expression of peroxisome proliferator activated receptor α and carnitine palmitoyltransferase-1. Moreover, BS15 enhanced the development of SNE gut by improving the intestinal development and digestion as well as adjusting the gut microflora. Therefore, BS15 may provide a promising natural preventative strategy against SNE, which may be contributed to the amelioration of lipid metabolism and intestinal microflora.

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“…FoxA2 has been shown in the liver to regulate the LpL gene; thus, FoxA2 may be another important regulator of lipid and glucose metabolic pathways. 107 Dietary fat is solubilized by bile acids in the intestine and, apart from the short-chain fatty acids, is absorbed by the lymphatic system passing to the liver. Triglyceride absorption is unregulated, so that fecal fat remains in very small quantities even in very-high-fat diets.…”

Section: Triglyceride and Cholesterol Absorption In Diabetesmentioning

confidence: 99%

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Tomkin¹,

Owens²

2017

DMSO

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Premature atherosclerosis in diabetes accounts for much of the decreased life span. New treatments have reduced this risk considerably. This review explores the relationship among the disturbances in glucose, lipid, and bile salt metabolic pathways that occur in diabetes. In particular, excess nutrient intake and starvation have major metabolic effects, which have allowed us new insights into the disturbance that occurs in diabetes. Metabolic regulators such as the forkhead transcription factors, the farnesyl X transcription factors, and the fibroblast growth factors have become important players in our understanding of the dysregulation of metabolism in diabetes and overnutrition. The disturbed regulation of lipoprotein metabolism in both the intestine and the liver has been more clearly defined over the past few years, and the atherogenicity of the triglyceride-rich lipoproteins, and – in tandem – low levels of high-density lipoproteins, is seen now as very important. New information on the apolipoproteins that control lipoprotein lipase activity has been obtained. This is an exciting time in the battle to defeat diabetic atherosclerosis.

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Regulation of the human lipoprotein lipase gene by the forkhead box transcription factor FOXA2/HNF-3β in hepatic cells

Cited by 17 publications

References 63 publications

Lactobacillus acidophilus LA14 Alleviates Liver Injury

Lactobacillus acidophilus LA14 Alleviates Liver Injury

Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens

Diabetes and dyslipidemia: characterizing lipoprotein metabolism

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