Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Tomkin, G. H.; Owens, D.

doi:10.2147/dmso.s115855

Cited by 39 publications

(38 citation statements)

References 134 publications

(131 reference statements)

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“…The higher lipid (Total-C, TRG, VLDL-C and LDL-C) level seen in plasma of diabetic rats (Table 6) in the present study is in agreement with previous studies (Ganjali et al, 2017). The abnormal high concentration of serum lipids in diabetes is mainly due to the increase in the mobilization of free fatty acids from the peripheral depots, since insulin inhibits the hormone sensitive lipase (Tomkin & Owens, 2017). On the other hand, glucagon, catecholamines and other hormones enhance lipolysis (Muller, Finan, Clemmensen, Marchi, & Tschöp, 2017).…”

Section: Discussionsupporting

confidence: 93%

Biochemical changes in diabetic rats treated with ethanolic extract of Chysophyllum albidum fruit-skin

Asagba

Kadiri

Ezedom

2019

JoBAZ

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Background: Diabetes mellitus (DM), also known as diabetes, involves a group of metabolic disorders in which blood sugar levels are high over a prolonged period. The present study was designed to evaluate the effect of 21 days administration of 100 and 200 mg per kg bodyweight of ethanolic extract of Chrysophyllum albidum (African star apple) fruit-skin on streptozotocin (STZ)-diabetic Wistar albino rats. A randomized control trial was used. Diabetic state of test rats was induced with streptozotocin at a dose of 60 mg streptozotocin/kg body using saline (0.9% w/v NaCl) as vehicle. Upon confirmation of diabetic state, crude ethanolic extract of C. albidum was dissolved in citrate buffer at pH 4.2 before administration to the rats at specific doses. Results: Results show a significant (p < 0.05) decreased in the level of plasma creatinine and insulin but increased level of glucose in diabetic rats relative to control. Induction of diabetes significantly increased the activities of alanine aminotransferases and aspartate aminotransferases in the liver and kidney and activities of both enzymes were also correspondingly increased in the plasma. There was significant increase in the level of total cholesterol, low-density lipoprotein-cholesterol, very low-density lipoprotein-cholesterol and triglyceride, but decreased highdensity lipoprotein-cholesterol in the test rats. Results also show alterations in the antioxidant status of experimental rats. The diabetic-induced changes were reversed in diabetic rats upon administration of C. albidum extract at a dose of 200 mg/kg body weight to levels comparable with control. Conclusion: The findings obtained revealed that ethanolic extract of C. albidum fruit-skin at a dose of 200 mg/kg body weight reversed the effect of diabetes due to its antihyperglycemic, anti-hyperlipidemic and antioxidant properties. The antidiabetic effect of the extract may be due to its abundant flavonoid and alkaloid contents.

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Section: Discussionsupporting

confidence: 93%

Biochemical changes in diabetic rats treated with ethanolic extract of Chysophyllum albidum fruit-skin

Asagba

Kadiri

Ezedom

2019

JoBAZ

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“…T2DM has been associated with abnormal triglyceride and cholesterol concentrations [31]. In this study, we observed that the diabetic risk alleles were associated with the elevated plasma levels of triglyceride and cholesterol, suggesting the possible participation of genetic variants of NF-YA in T2DM etiology.…”

Section: Discussionsupporting

confidence: 49%

Effects of Genetic Variants of Nuclear Receptor Y on the Risk of Type 2 Diabetes Mellitus

Wang

Yang

Guan

et al. 2019

Journal of Diabetes Research

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Nuclear factor-Y (NF-Y) consists of three evolutionary conserved subunits including NF-YA, NF-YB, and NF-YC; it is a critical transcriptional regulator of lipid and glucose metabolism and adipokine biosynthesis that are associated with type 2 diabetes mellitus (T2DM) occurrence, while the impacts of genetic variants in the NF-Y gene on the risk of T2DM remain to be investigated. In the present study, we screened five single-nucleotide polymorphisms (SNPs) with the SNaPshot method in 427 patients with T2DM and 408 healthy individuals. Subsequently, we analyzed the relationships between genotypes and haplotypes constructed from these SNPs with T2DM under diverse genetic models. Furthermore, we investigated the allele effects on the quantitative metabolic traits. Of the five tagSNPs, we found that three SNPs (rs2268188, rs6918969, and rs28869187) exhibited nominal significant differences in allelic or genotypic frequency between patients with T2DM and healthy individuals. The minor alleles G, C, and C at rs2268188, rs6918969, and rs28869187, respectively, conferred a higher T2DM risk under a dominant genetic model, and the carriers of these risk alleles (either homozygotes of the minor allele or heterozygotes) had statistically higher levels of fasting plasma glucose, cholesterol, and triglycerides. Haplotype analysis showed that SNPs rs2268188, rs6918969, rs28869187, and rs35105472 formed a haplotype block, and haplotype TTAC was protective against T2DM (OR=0.76, 95% CI=0.33-0.82, P=0.004), while haplotype GCCG was associated with an elevated susceptibility to T2DM (OR=2.33, 95% CI=1.43-3.57, P=0.001). This study is the first ever observation to our knowledge that indicates the genetic variants of NF-YA might influence a Chinese Han individual’s occurrence of T2DM.

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“…Hypertriglyceridemia is a lipid abnormality commonly observed in obese individuals and patients with cardiovascular disease (CVD) or diabetes [ 1 2 ]. It is considered to be an independent risk factor for atherosclerosis in patients with type 2 diabetes [ 3 4 ].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein A53'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey

Kim

Moon

et al. 2018

Nutr Res Pract

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BACKGROUND/OBJECTIVESThis study aimed to test the association between APOA5 3'-UTR variants (rs662799) and cardiometabolic traits in Koreans.SUBJECTS/METHODSFor this study, epidemiological data, Apolipoprotein A5 (APOA5) genotype information, and lymphoblastoid cell line (LCL) biospecimens from a subset of the Ansung-Ansan cohort within the Korean Genome and Epidemiology study (KoGES-ASAS; n = 7,704) as well as epidemiological data along with genomic DNA biospecimens of participants from a subset of the Korea National Health and Nutrition Examination Survey (KNHANES 2011-12; n = 2,235) were obtained. APOA5 mRNA expression was also measured.RESULTSAPOA5 rs662799 genotype distributions in both the KoGES-ASAS and KNHANES groups were 50.6% for TT, 41.3% for TC, and 8.1% for CC, which are similar to those in previous reports. In both groups, minor C allele carriers, particularly subjects with CC homozygosity, had lower high-density lipoprotein (HDL) cholesterol and higher triglyceride levels than TT homozygotes. Linear regression analysis showed that the minor C allele significantly contributed to reduction of circulating HDL cholesterol levels [β = −2.048, P < 0.001; β = −2.199, P < 0.001] as well as elevation of circulating triglyceride levels [β = 0.053, P < 0.001; β = 0.066, P < 0.001] in both the KoGES-ASAS and KNHANES groups. In addition, higher expression levels of APOA5 in LCLs of 64 healthy individuals were negatively associated with body mass index (r = −0.277, P = 0.027) and circulating triglyceride level (r = −0.340, P = 0.006) but not significantly correlated with circulating HDL cholesterol level. On the other hand, we observed no significant difference in the mRNA level of APOA5 according to APOA5 rs662799 polymorphisms.CONCLUSIONSThe C allele of APOA5 rs662799 was found to be significantly associated with cardiometabolic traits in a large Korean population from the KoGES-ASAS and KNHANES. The effect of this genotype may be associated with post-transcriptional regulation, which deserves further experimental confirmation.

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Diabetes and dyslipidemia: characterizing lipoprotein metabolism

Cited by 39 publications

References 134 publications

Biochemical changes in diabetic rats treated with ethanolic extract of Chysophyllum albidum fruit-skin

Biochemical changes in diabetic rats treated with ethanolic extract of Chysophyllum albidum fruit-skin

Effects of Genetic Variants of Nuclear Receptor Y on the Risk of Type 2 Diabetes Mellitus

Apolipoprotein A53'-UTR variants and cardiometabolic traits in Koreans: results from the Korean genome and epidemiology study and the Korea National Health and Nutrition Examination Survey

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