Regulation of Stem Cell Populations

Drummond‐Barbosa, Daniela

doi:10.1002/3527600906.mcb.200500015

Cited by 3 publications

(1 citation statement)

References 108 publications

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“…Stem cells reside in a specialized microenvironment, or niche, where they receive local signals, such as bone morphogenetic proteins (BMPs), Hedgehogs, and Wnts that regulate their maintenance and proliferation (Li and Xie, 2005;Spradling et al, 2001). Despite the unquestionable importance of local signals in regulating stem cells, stem cell activity is also influenced by stimuli originating outside of the tissues in which they reside, such as diet, hormones, or physical insults (Drummond-Barbosa, 2005;Narbonne and Roy, 2006b). By 1 These authors contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila

Hsu

LaFever

Drummond‐Barbosa

2008

Developmental Biology

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The external environment influences stem cells, but this process is poorly understood. Our previous work showed that germline stem cells (GSCs) respond to diet via neural insulin-like peptides (DILPs) that act directly on the germ line to upregulate stem cell division and cyst growth under a protein-rich diet in Drosophila. Here, we report that DILPs specifically control the G2 phase of the GSC cell cycle via phosphoinositide-3 kinase (PI3K) and dFOXO, and that a separate diet mediator regulates the G1 phase. Furthermore, GSC tumors, which escape the normal stem cell regulatory microenvironment, or niche, still respond to diet via both mechanisms, indicating that niche signals are not required for GSCs to sense or respond to diet. Our results document the effects of diet and insulin-like signals on the cell cycle of stem cells within an intact organism and demonstrate that the response to diet requires multiple signals. Moreover, the retained ability of GSC tumors to respond to diet parallels the long known connections between diet, insulin signaling, and cancer risk in humans.

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Section: Introductionmentioning

confidence: 99%

Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila

Hsu

LaFever

Drummond‐Barbosa

2008

Developmental Biology

Self Cite

163

211

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Stem Cells, Their Niches and the Systemic Environment: An Aging Network

Drummond‐Barbosa

2008

Genetics

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113

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Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity of stem cells, it is much less well understood how stem cells sense and respond to variable external, physiological, or tissue environments. This review focuses on the multidirectional interactions among stem cells, niches, tissues, and the systemic environment and on potential ideas for how changes in this network of communication may relate to the aging process.

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Stress-induced ECM alteration modulates cellular microRNAs that feedback to readjust the extracellular environment and cell behavior

Edeleva¹,

Shcherbata²

2013

Front. Genet.

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The extracellular environment is a complex entity comprising of the extracellular matrix (ECM) and regulatory molecules. It is highly dynamic and under cell-extrinsic stress, transmits the stressed organism’s state to each individual ECM-connected cell. microRNAs (miRNAs) are regulatory molecules involved in virtually all the processes in the cell, especially under stress. In this review, we analyse how miRNA expression is regulated downstream of various signal transduction pathways induced by changes in the extracellular environment. In particular, we focus on the muscular dystrophy-associated cell adhesion molecule dystroglycan capable of signal transduction. Then we show how exactly the same miRNAs feedback to regulate the extracellular environment. The ultimate goal of this bi-directional signal transduction process is to change cell behavior under cell-extrinsic stress in order to respond to it accordingly.

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Regulation of Stem Cell Populations

Cited by 3 publications

References 108 publications

Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila

Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila

Stem Cells, Their Niches and the Systemic Environment: An Aging Network

Stress-induced ECM alteration modulates cellular microRNAs that feedback to readjust the extracellular environment and cell behavior

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