Regulation of retinal blood flow in health and disease

Pournaras, Constantin J.; Rungger‐Brändle, Elisabeth; Riva, Charles E.; Hardarson, Sveinn Hákon; Stefánsson, Einar

doi:10.1016/j.preteyeres.2008.02.002

Cited by 516 publications

(491 citation statements)

References 437 publications

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“…The EC are joined together by thin discontinuous bonds (zonula occludens), desmosomes, and communicating junctions (gaps) [37,38,56]. In addition, they have the peculiarity of presenting fenestrations on the side oriented towards Bruch's membrane and the RPE [37][38][39].…”

Section: Choriocapillarismentioning

confidence: 99%

“…Experimental studies have demonstrated that sympathetic innervation is critical in the regulation of choroidal vascularization [73], and that the chronic loss of sympathetic activity can contribute to the anomalous vascular proliferation noted in diseases such as age-related macular degeneration (ARMD) [74] and diabetic retinopathy [75,76]. Furthermore, the loss of this innervation can cause oedema in the retina [71], a circumstance that could be important in illnesses such as diabetes or hypertension, in which automatic control is altered [56].…”

Section: Neural Control Of Choroidal Blood Flow In Ocular Diseasesmentioning

confidence: 99%

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Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Sebastián¹,

Corral²,

Montañana³

et al. 2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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Section: Choriocapillarismentioning

confidence: 99%

Section: Neural Control Of Choroidal Blood Flow In Ocular Diseasesmentioning

confidence: 99%

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Sebastián¹,

Corral²,

Montañana³

et al. 2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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“…Contrarily, retinal circulation is regulated by local factors, such as mechanical pressure, oxygen tension, and pH (3). Of note, retinal metabolism is one of the highest in the human organism (4), and retina is considered one of the most O 2 -sensitive tissues (5). Requirements of oxygen and nutrients might pose a serious challenge during prolonged hypoxic and/or ischemic periods.…”

mentioning

confidence: 99%

Metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia

et al. 2014

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Background: Hypoxic-ischemic insults to the neonatal brain may cause neurodevelopmental disorders. Vulnerability of different areas of the neural tissue to hypoxic-ischemic stress might be explained by either heterogeneous sensitivity to oxygen or neuroprotective capability. Our understanding of regional heterogeneity is still incomplete in terms of metabolic reconfiguration and/or activation of neuroprotective mechanisms. Methods: We studied, by western blotting, reversetranscriptase PCR, and tandem mass spectrometry, the response of retina and choroid at protein, gene, and metabolic levels during hypoxia in a piglet model of acute postnatal hypoxia. results: We evidenced a metabolic shift towards glycolysis in choroid after hypoxia while retina experienced a dramatic energy stress with decreased mitochondrial metabolites. Hypoxia-inducible transcription factor-1α (HIF-1α) was not stabilized in retina during hypoxia, supported by a deficient signaling from v-akt murine thymoma viral oncogene (AKT) and ERK1/2, and unchanged glutathione redox status. In retina, but not in choroid, phosphorylation of p65 (NF-κB) and increased transcription of target genes may have a major role during hypoxic stress. conclusion: We showed that the retina engages a distinct pattern of signaling and transcriptional events than observed in the choroid. Retina and choroid may reflect regional sensitivity to hypoxia. While prolonged and intense hypoxia may jeopardize retinal cell survival, choroid sets up a different pattern of response, which promotes adaptation to these adverse conditions.

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“…The parameters are chosen to be comparable to those found in [16,24,25] and they are a realistic and representative set of parameters for retinal arterioles. The parameters used for the arteriole wall are ρ s = 1g/cm 3 , E = 0.05M P a, ν = 0.5, h κ = 5µm, h f = 20µm, k 0 = 0.4M P a, k 1 = 0, w = v = 0.5.…”

Section: Applicationmentioning

confidence: 99%

A simplified fluid–structure model for arterial flow. Application to retinal hemodynamics

Aletti

Gerbeau

Lombardi

2016

Computer Methods in Applied Mechanics and Engineering

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A simplified fluid-structure model for arterial flow.Application to retinal hemodynamics. AbstractWe propose a simplified fluid-structure interaction model for applications in hemodynamics. This work focuses on simulating the blood flow in arteries, but it could be useful in other situations where the wall displacement is small. As in other approaches presented in the literature, our simplified model mainly consists of a fluid problem on a fixed domain, with Robin-like boundary conditions and a first order transpiration. Its main novelty is the presence of fibers in the solid. As an interesting numerical side effect, the presence of fibers makes the model less sensitive than others to strong variations or inaccuracies in the curvatures of the wall. An application to retinal hemodynamics is investigated.

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Regulation of retinal blood flow in health and disease

Cited by 516 publications

References 437 publications

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Choroidal Vessel Wall: Hypercholesterolaemia-Induced Dysfunction and Potential Role of Statins

Metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia

A simplified fluid–structure model for arterial flow. Application to retinal hemodynamics

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