Regulation of Pancreatic Secretion

Regulation of Pancreatic Secretion

“…Various reports describe norepinephrine stimulating, inhibiting, or having no effect on pancreatic secretion. 125 122,123 Norepinephrine is believed to be the primary transmitter released by intrapancreatic adrenergic nerves.…”

Effect of cinnamtannin B‐1 on cholecystokinin‐8‐evoked responses in mouse pancreatic acinar cells

“…Cholecystokinin-8 evokes a biphasic response in amylase secretion, with inhibition at supramaximal concentrations, as reported previously. 45 In addition, high concentrations of CCK-8 induce ROS production 34 and ROS inhibit amylase secretion. 46 A hyperstimulation of the gland, which is related to a prolonged, global increase in cytosolic Ca 2+ , may lead to pancreatitis.…”

Cholecystokinin

“…This effect appears to be mediated by an endogenous protease-sensitive CCK-releasing peptide in the intestinal lumen (30,50,85). In addition to proteases, bile acids in the intestine affect CCK secretion (26,55). In rats, luminal administration of taurocholate inhibited pancreatic enzyme secretion as well as CCK (90).…”

“…There is evidence for neural activation of vagal afferents in the intestinal mucosa which express CCK1 receptors and terminate in the lamina propria (74). Although the effect of CCK on the vagus nerve was believed to be paracrine or hormonal action, recently, CCK cells have been shown to be in direct contact with neurons (7,12,53) and this connection may provide a direct neural link between the gut and brain.…”

“…Based on this biological property, the hormone was named cholecystokinin (CCK). In addition to gallbladder contraction, CCK was later shown to stimulate pancreatic secretion (55) and to delay gastric emptying by its effect on the lower esophageal sphincter (80). CCK was the first hormone shown to influence satiety and cause reduction in food intake (23).…”