Regulation of Pancreatic Secretion

Liddle, Rodger A.

doi:10.1016/b978-0-12-382026-6.00052-x

Cited by 14 publications

(6 citation statements)

References 341 publications

(318 reference statements)

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“…The stimulation in the gut might be of mechanical and/or biochemical nature. High tryptic enzyme activity in the gut acts as a negative feedback control for the release of CCK in humans, suggesting a regulatory loop between these two factors (Liddle, 2006) and the same mechanism has been described in adult fish (Murashita et al, 2008). The spatial distribution of the CCK-producing cells in the larval gut seems to vary between fish species (e.g.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

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Hormonal control of tryptic enzyme activity in Atlantic cod larvae (Gadus morhua): Involvement of cholecystokinin during ontogeny and diurnal rhythm

et al. 2013

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Please cite this article as: Tillner, Robert, Rønnestad, Ivar, Harboe, Torstein, Ueberschär, Bernd, Hormonal control of tryptic enzyme activity in Atlantic cod larvae (Gadus morhua): Involvement of cholecystokinin during ontogeny and diurnal rhythm, Aquaculture (2013Aquaculture ( ), doi: 10.1016Aquaculture ( /j.aquaculture.2013 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT AbstractThe ontogenetic development of the gut hormone cholecystokinin (CCK) and the key proteolytic enzyme trypsin was described in Atlantic cod larvae (Gadus morhua) from first-feeding until 38 days post first-feeding (dpff). CCK is known to play a major role in the endocrine control of digestive processes in mammals and adult fish, but its regulatory role in the larval stages of marine fish is largely unknown. Only small amounts of CCK were found in the body (excluding head) in cod larvae at first-feeding, but CCK levels increased exponentially with development, suggesting a more pronounced role of CCK during ontogeny. Tryptic enzyme activity increased slightly until a standard length of ca. 8 mm (approx. 33 days dpff) with a significant increase in larvae larger than 8 mm standard length, indicating limited digestive capacity in the early stages. To entangle the short-term feedback mechanism between CCK and tryptic enzyme activity, we conducted a 12 hour feeding experiment at 21 dpff. Cod larvae receiving only algae revealed a noticeable response in tryptic enzyme activity within two hours in the morning, whereas larvae fed algae and rotifers at the same time showed a slightly delayed response up to four hours. Tryptic enzyme activity remained low in the group receiving only algae as well as the two fed groups in the afternoon. No reaction in tryptic enzyme activity was observed in larvae that received a second meal of rotifers in the afternoon, indicating limited regulatory and digestive capacity to handle several meals in a short period. CCK levels remained relatively constant throughout the day but increased in the afternoon in all three groups when tryptic enzyme activity was low, suggesting that a negative feedback mechanism between CCK and tryptic enzyme activity is present in larval cod at least from 21 dpff.

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Section: Accepted M Manuscriptmentioning

confidence: 99%

“…In addition, it acts as a satiation signal in the fish brain (Volkoff et al, 2005). In mammals, CCK is considered one of the most important stimulators of pancreatic enzyme secretion (Liddle, 2006) and is therefore an obvious candidate to…”

Section: Introductionmentioning

confidence: 99%

Hormonal control of tryptic enzyme activity in Atlantic cod larvae (Gadus morhua): Involvement of cholecystokinin during ontogeny and diurnal rhythm

et al. 2013

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“…Traditionally, EECs were viewed exclusively as hormone-producing cells of the gastrointestinal tract; however, we recently discovered that EECs also connect to neurons (33,34). Their location places EECs at the interface between gut contents and the nervous system and provides a direct route for substances in the gut to affect neural function.…”

Section: Introductionmentioning

confidence: 99%

α-Synuclein in gut endocrine cells and its implications for Parkinson’s disease

Chandra

Hiniker²,

Kuo³

et al. 2017

JCI Insight

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176

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“…Thus insulin secretion in Kir6.2 −/− mice is mediated by the ATP-independent parasympathetic system. Since the cephalic component contributes ~25–50% of insulin secretion [20], the above data suggest that in the absence of functional K ATP channels, the cephalic phase could have a much larger impact by serving as a compensatory mechanism in glucose homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the regulation of pancreatic secretion

Chandra

Liddle²

2014

Current Opinion in Gastroenterology

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Purpose of review This review highlights recent progress made in the field of pancreatic secretion. Significant findings This review summarizes a number of recent studies demonstrating the intracellular pathways by which hormones and neural inputs regulate pancreatic exocrine and endocrine secretion. In particular, the effects of VIP and secretin on intra-acinar cell cAMP are explored. Considerable attention is paid to regulation of β-cell function and includes studies detailing the mechanisms of regulation of insulin by somatostatin, serotonin, and melanocortins. These studies emphasize the critical role that hormonal, paracrine, and neural factors play in glucose homeostasis. Summary Exocrine and endocrine pancreatic secretions are regulated by hormonal and neural mechanisms and understanding these pathways will enable the discovery and design of new and improved therapies for prevention and control of diabetes and perhaps exocrine insufficiency.

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Regulation of Pancreatic Secretion

Cited by 14 publications

References 341 publications

Hormonal control of tryptic enzyme activity in Atlantic cod larvae (Gadus morhua): Involvement of cholecystokinin during ontogeny and diurnal rhythm

Hormonal control of tryptic enzyme activity in Atlantic cod larvae (Gadus morhua): Involvement of cholecystokinin during ontogeny and diurnal rhythm

α-Synuclein in gut endocrine cells and its implications for Parkinson’s disease

Recent advances in the regulation of pancreatic secretion

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