Regulation of Oocyte Growth in the Mouse Ovary

Krarup, T; Pedersen, Tore; Faber, Mogens

doi:10.1038/224187a0

Cited by 84 publications

(48 citation statements)

References 4 publications

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“…There is known to be a positive correlation between these 2 parameters in intact mice (Krarup, Pedersen & Faber, 1969) and for the present control data this relationship is illustrated by the regression lines shown in Text-figs 3(a) and 3(b). For the 4-week age group all the data for the treated group are above the control regression line, which is a reflection of the increased numbers of growing follicles.…”

Section: Introductionmentioning

confidence: 72%

The number of oocytes and the rate of atresia in unilaterally ovariectomized mice up to 8 months after surgery

Baker¹,

Challoner²,

Burgoyne³

1980

Reproduction

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Section: Introductionmentioning

confidence: 72%

The number of oocytes and the rate of atresia in unilaterally ovariectomized mice up to 8 months after surgery

Baker¹,

Challoner²,

Burgoyne³

1980

Reproduction

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“…This implies the existence of another source of inhibition at this stage, and makes the mouse neonatal ovary a valuable model for the study of follicle growth initiation. Another potential source of inhibitor could be the primordial follicles themselves (15,16) (Fig. 1B).…”

mentioning

confidence: 99%

Inferring biological mechanisms from spatial analysis: Prediction of a local inhibitor in the ovary

Silva-Buttkus

Marcelli

Franks

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Female mammals are born with a lifetime's supply of oocytes individually enveloped in flattened epithelial cells to form primordial follicles. It is not clear how sufficient primordial follicles are maintained to sustain the reproductive lifespan, while providing an adequate supply of mature oocytes for ovulation. Locally produced growth factors are thought to be critical regulators of early follicle growth, but knowledge of their identity and source remains incomplete. Here, we have used a simple approach of spatial analysis of structures in histological tissue sections to identify likely sources of such regulatory molecules, narrowing the field for future screening for candidate growth factors or antagonists. We have quantified the relative spatial positions of primordial (resting) follicles and growing follicles in mice on days 4, 8, and 12 after birth, and calculated interfollicular distances. Follicles were significantly less likely to have started growing if they had 1 or more primordial follicles close by (within 10 m), predicting that primordial follicles inhibit each other. This approach allows us to hypothesize that primordial follicles produce a diffusible inhibitor that prevents neighboring primordial follicles from growing. Such an approach has wide applicability within many branches of developmental and cell biology for studying spatial signaling within tissues and cells.diffusing inhibitor ͉ follicle growth ͉ signal gradient

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“…The few follicles present in potential preneoplastic ovaries showed a labelling index of the granulosa cells comparable to that of normal mice (Pedersen and Krarup, 1969). Some empty rings and pseudofollicles had a few labelled cells, but the majority of them were unlabelled.…”

Section: Proliferation Pattern Of Pathological Ovarian Tissuementioning

confidence: 77%

“…After oral administration of DMBA the number of developing oocytes in follicles is secondarily reduced, while after intraperitoneal injection some follicles are directly destroyed in addition (Krarup, 1969b). The immediate effect of DMBA on the granulosa cells of the follicles, however, is a transient one, which causes a temporary acceleration of the follicle growth rate; when this stimulating effect has subsided the remaining follicles continue to develop normally (Pedersen and Krarup, 1969). The labelling index of the last remaining follicles was normal and their ability to ovulate was preserved (Fig.…”

Section: Disappearance Of Oocytes and Its Relation To Tumorigenesismentioning

confidence: 99%

“…type 3b and type 4 follicles; Pedersen and Peters, 1968) are not destroyed by DMBA. Their number decreases because the pool of small oocytes-from which they are recruited-is reduced (Krarup, 1969b;Krarup et al, 1969). Furthermore, there is a considerable discrepancy between the number of empty rings and pseudofollicles present in a preneoplastic ovary and the number of type 3b and type 4 follicles in a normal ovary.…”

Section: Histogenesis Of Ovarian Tumoursmentioning

confidence: 99%

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Effect of 9,10-Dimethyl-1,2-Benzanthracene on the Mouse Ovary. Ovarian Tumorigenesis

Krarup¹

1970

Br J Cancer

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SUMMARY.-Groups of immature and mature mice were treated once with DMBA by oral or intraperitoneal route, and the subsequent bilateral sequence of ovarian changes leading to the development of unilateral granulosa cell tumour was studied.Early post-treatment changes included disappearance of oocytes and follicles as well as increase of the stroma mass. The neoplastic development was closely correlated to the rate of oocyte disappearance. The faster oocytes were eliminated, the earlier tumours appeared. The early post-treatment changes led to a stage of potential preneoplasia, characterized by diffuse luteinization of the ovarian parenchyma. In some preneoplastic ovaries the luteinized tissue underwent neoplastic transformation and developed into invasive luteoma. In other preneoplastic ovaries foci of granulosa-like tumour cells appeared in the luteinized tissue, representing the stage of microscopic granulosa cell tumour. However, such microtumours could also develop within pre-existing luteomata. Autoradiography after injection of thymidine-3H suggested that the granulosa-like tumour cells developed as the result of undifferentiated proliferation of luteinized cells.So far the pathological ovarian evolution occurred bilaterally as well as unilaterally. However, when a microscopic granulosa cell tumour by further growth became a macroscopic granulosa cell tumour the contralateral ovary invariably atrophied. This ultimate unilateral development coincided with a continuous production of oestrogen by the granulosa cell tumour. The reason for the contralateral atrophy is discussed in relation to the influence of the hormonal balance on ovarian tumorigenesis. THE carcinogenic hydrocarbon 9,10-dimethyl-1,2-benzanthracene (DMBA) administered to sensitive strains of mice affects the ovaries and induces granulosa cell tumours regardless of whether it is applied externally to the skin (Howell et al

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Regulation of Oocyte Growth in the Mouse Ovary

Cited by 84 publications

References 4 publications

The number of oocytes and the rate of atresia in unilaterally ovariectomized mice up to 8 months after surgery

The number of oocytes and the rate of atresia in unilaterally ovariectomized mice up to 8 months after surgery

Inferring biological mechanisms from spatial analysis: Prediction of a local inhibitor in the ovary

Effect of 9,10-Dimethyl-1,2-Benzanthracene on the Mouse Ovary. Ovarian Tumorigenesis

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