2009
DOI: 10.1073/pnas.0810012106
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Inferring biological mechanisms from spatial analysis: Prediction of a local inhibitor in the ovary

Abstract: Female mammals are born with a lifetime's supply of oocytes individually enveloped in flattened epithelial cells to form primordial follicles. It is not clear how sufficient primordial follicles are maintained to sustain the reproductive lifespan, while providing an adequate supply of mature oocytes for ovulation. Locally produced growth factors are thought to be critical regulators of early follicle growth, but knowledge of their identity and source remains incomplete. Here, we have used a simple approach of … Show more

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Cited by 87 publications
(66 citation statements)
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“…Increasing evidence suggests that primordial follicles release inhibitory factors or negative regulators which could explain why some primordial follicles remain dormant, while others are activated [15]. In the light of our earlier results which demonstrated the presence of AR in the fetal porcine ovaries [12], we assume that imbalance in the androgen milieu may affect the expression of some intraovarian factors responsible for the fetal folliculogenesis.…”
Section: Introductionmentioning
confidence: 92%
“…Increasing evidence suggests that primordial follicles release inhibitory factors or negative regulators which could explain why some primordial follicles remain dormant, while others are activated [15]. In the light of our earlier results which demonstrated the presence of AR in the fetal porcine ovaries [12], we assume that imbalance in the androgen milieu may affect the expression of some intraovarian factors responsible for the fetal folliculogenesis.…”
Section: Introductionmentioning
confidence: 92%
“…The initially sparse density may have enabled follicle activation into the growing pool, as primordial follicles are usually at high density in the ovary, which may serve to modulate their growth. 38 However, the subsequent aggregation between days 9 and 21 may have contributed to follicle survival and growth, 38,39 as paracrine signaling influences follicle growth. While follicle transplantation has many challenges that are noted earlier, a potential advantage of this approach is the delivery of a known number and density of follicles.…”
Section: Discussionmentioning
confidence: 99%
“…The preferential location of the reserve to the ovarian cortex with growing follicles mostly confined to the medulla (Da Silva-Buttkus et al 2009) suggests a follicle-derived gradient of inhibitory and stimulatory signals that reflect this arrangement. Spatial analysis of primordial follicles has led to the proposal that these follicles inhibit each other by producing as yet unidentified paracrine factors that prevent their activation into primary follicles (Da Silva-Buttkus et al 2009). Perhaps growing follicles influence the rate of entry of primordial follicles into the growth phase, and the phenotype of the anti-Mullerian hormone (AMH) knockout mouse suggests that AMH may contribute to this (Durlinger et al 1999).…”
Section: What Controls Oocyte Death To Establish the Reserve?mentioning
confidence: 99%