Regulation of iron metabolism in the acute‐phase response: interferon γ and tumour necrosis factor α induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients

Feelders, Richard A; Vreugdenhil, Gerard; Eggermont, A. M. M.; Kuiper-Kramer, P.A.; Eijk, H.G. Van; Swaak, A. J. G.

doi:10.1046/j.1365-2362.1998.00323.x

Cited by 168 publications

(140 citation statements)

References 54 publications

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“…However, after 6 h the IL-6 was decreased as compared with the value 1 h earlier. This is in accordance with the results of earlier studies, which indicate that IL-6 level begins to decline somewhere between 4 and 8 h after the onset of infection/inflammation (Meffert et al, 1994;Berger et al, 1997;Feelders et al, 1998).…”

Section: Resultssupporting

confidence: 93%

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Capturing the onset of the common cold and its effects on iron absorption

Hoppe

Hulthén

2007

Eur J Clin Nutr

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Hypoferremia is a well-known response to infections and inflammatory disorders. It seems to be managed by the key mediator of iron kinetics, hepcidin. There are several studies on induced-acute phase reactions. However, to our best knowledge there are no previous published reports on the outbreak of a common cold and its initial effect on iron kinetics. The objective of this case report is to describe such an observation. From an apparently healthy state in the morning we observed, in a 28-year-old male, every hour for 6 h the outbreak of a common cold and the modulations in the levels of serum iron (S-Fe) and interleukin-6 (IL-6). Despite a 100 mg oral iron loading there was a substantial reduction in S-Fe, which seemed to precede the IL-6 peak. Interestingly, this observed succession is in conflict with the proposed infection chain of order in which IL-6 stimulates hepcidin induction.

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Section: Resultssupporting

confidence: 93%

“…Despite an alteration in the other iron parameters the S-ferritin level remained constant throughout the day (51.870.8 mg/l, mean7s.e.m. ), probably owing to the previously reported delay in the alteration of ferritin kinetic (Feelders et al, 1998;Kemna et al, 2005).…”

Section: Resultsmentioning

confidence: 86%

Capturing the onset of the common cold and its effects on iron absorption

Hoppe

Hulthén

2007

Eur J Clin Nutr

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“…A better alternative to CRP is thought to be AGP, which remains elevated for a longer duration of time. One time course study that followed changes in concentration of multiple APPs and iron status measurements, found that SF concentrations rose steadily reaching a peak, like CRP, at day 2, but like AGP, remained elevated for several subsequent days (Feelders et al, 1998). It is because of this extended period of elevation in SF and AGP that AGP is thought to better reflect the changes in SF that accompany the APR.…”

Section: Discussionmentioning

confidence: 99%

Influence of inflammation as measured by α-1-acid glycoprotein on iron status indicators among HIV-positive postpartum Zimbabwean women

et al. 2008

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“…For instance, inflammation/infection can be accompanied by decreased Hb and increased ferritin. CRP rises rapidly in response to inflammation and decreases toward normal within 36-48 hr, whereas both ferritin and AGP may remain elevated for as long as 5-10 days after the onset of an acute inflammatory response [34,35]. Lead concentrations above 15-18 mg/dl can impair red cell production, reflected in elevated FEP values [36].…”

Section: Methodsmentioning

confidence: 99%

Iron status of inner‐city African‐American infants

et al. 2006

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The iron status of African-American infants continues to be subject to debate. We characterized the iron status of 198 9-month-old inner-city infants (94% fed iron-fortified formula) using a comprehensive panel of measures and assessing lead and inflammation markers. The proportion with iron deficiency was calculated based on three approaches (! ! ! ! 2 abnormal iron measures with or without anemia for MCV model-NHANES II, ferritin model-NHANES III, or Sweden/Honduras study) and a promising new measure-body iron, calculated from ferritin and transferrin receptor (TfR). There were no sex differences for any iron measure. Hb < 110 g/l was observed in 25%; Hb 105 g/l in 10.1%. Free erythrocyte protoporphyrin (FEP) values were elevated without elevated lead concentrations or an inflammatory response: mean FEP = 86.6 lg/dl red blood cells [75.5 lmol/mol heme]; 52.3% were > 80 lg/dl (1.42 lmol/l), almost half of which were accompanied by a second abnormal iron measure. The estimated prevalence of iron deficiency was 14.4, 5.3, and 2.5% for the MCV model, ferritin model, and Sweden/Honduras cutoffs, respectively, and 4.1% for body iron < 0 mg/kg. Regulation of iron storage is immature at < 1 year of age, making estimates of iron deficiency that depend on ferritin, including body iron, suspect in this age period. Thus, the ''true'' prevalence of iron deficiency could not be established with confidence due to major differences in the results, depending on the guidelines used. Functional indicators of poor iron status in young infants are urgently needed. Am. J. Hematol. 82:112-121, 2007. V V C 2006 Wiley-Liss, Inc.

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Regulation of iron metabolism in the acute‐phase response: interferon γ and tumour necrosis factor α induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients

Cited by 168 publications

References 54 publications

Capturing the onset of the common cold and its effects on iron absorption

Capturing the onset of the common cold and its effects on iron absorption

Influence of inflammation as measured by α-1-acid glycoprotein on iron status indicators among HIV-positive postpartum Zimbabwean women

Iron status of inner‐city African‐American infants

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