Capturing the onset of the common cold and its effects on iron absorption

Hoppe, Michael; Hulthén, Lena

doi:10.1038/sj.ejcn.1602614

Cited by 7 publications

(5 citation statements)

References 18 publications

(23 reference statements)

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“…Limited research data from adult populations attempt to elucidate the role of hepcidin in the common cold, iron metabolism disorders, chronic kidney disease, chronic hepatitis C and kidney transplant recipients [25-27]. In an adult patient population study group, hepcidin was demonstrated as a potentially useful marker that reflects the degree of billiary inflammation in cholecystitis and primary sclerosing cholangitis (PSC) - associated bacterial infection.…”

Section: Discussionmentioning

confidence: 99%

Serum hepcidin: indication of its role as an “acute phase” marker in febrile children

Kossiva

Soldatou

Gourgiotis³

et al. 2013

Ital J Pediatr

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BackgroundHepcidin is classified as a type II acute phase protein; its production is a component of the innate immune response to infections.ObjectiveTo evaluate the alterations of serum hepcidin in children during and following an acute febrile infection.Materials and methods22 children with fever of acute onset (< 6 hours) admitted to the 2nd Department of Pediatrics-University of Athens. Based on clinical and laboratory findings our sample formed two groups: the viral infection group (13 children) and the bacterial infection group (9 children). Hepcidin, ferritin and serum iron measurements were performed in all subjects.ResultsSerum hepcidin values did not differ notably between children with viral and bacterial infection, but a significant reduction of hepcidin was noted in both groups post-infection.ConclusionOur study provides clinical pediatric data on the role of hepcidin in the face of an acute infection. In our sample of children, hepcidin was found to rise during the acute infection and fall post-infection.

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Section: Discussionmentioning

confidence: 99%

Serum hepcidin: indication of its role as an “acute phase” marker in febrile children

Kossiva

Soldatou

Gourgiotis³

et al. 2013

Ital J Pediatr

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“…Although the role of such a feedback mechanism remains speculative, there is clear evidence for each step in this process. Significantly elevated IL-6 levels have been measured in South American hemorrhagic fevers [27], and increased IL-6 and hepcidin is observed with several other viral infections, for example in individuals acutely infected with common cold viruses or chronically infected with hepatitis C virus [9,33]. The links between IL-6 levels, hepcidin concentration, hypoferremia, and TfR1 upregulation have also been established [25].…”

Section: Iron Sequestration Tfr1 Expression and Arenaviral Hemorrhamentioning

confidence: 95%

Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses

Choe

Jemielity

Abraham

et al. 2011

Current Opinion in Microbiology

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At least five New World arenaviruses cause severe human hemorrhagic fevers. These viruses are transmitted to humans through contact with their respective South American rodent hosts. Each uses human transferrin receptor 1 (TfR1) as its obligate receptor. Accidental similarities between human TfR1 and TfR1 orthologs of arenviral host species enable zoonoses, whereas mice and rats are not infectable because they lack these TfR1 determinants of infection. All pathogenic New World arenaviruses bind to a common region of the apical domain of TfR1. The ability of a New World arenavirus to use human TfR1 is absolutely predictive of its ability to cause hemorrhagic fevers in humans. Non-pathogenic arenaviruses, closely related to hemorrhagic fever arenaviruses, cannot utilize human TfR1 but efficiently enter cells through TfR1 orthologs of their native rodent hosts. Mutagenesis studies suggest that minor changes in the entry glycoproteins of these non-pathogenic viruses may allow human transmission. TfR1 is upregulated as a result of iron sequestration during the acute phase response to infection, and the severity of disease may result from amplification of viral replication during this response.

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“…Neither could they take any dietary supplements (including iron) or use any probiotic containing products during the study or within two weeks prior to the study. Exclusion criteria also included infection / inflammation since an activated acute-phase reaction can cause extensive changes in body iron metabolism, including reduced iron absorption [ 44 – 46 ]. In the event of an activated acute-phase response, S-ferritin is falsely elevated [ 47 ].…”

Section: Ethicsmentioning

confidence: 99%

Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females—Double isotope sequential single-blind studies in menstruating women

2017

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BackgroundThe probiotic strain Lactobacillus plantarum 299v has earlier been shown to increase iron absorption when added to foods. However, it is not known if the same probiotic strain in a freeze-dried format included in a capsule increases the iron absorption.ObjectiveThe aim of this study was to test the hypotheses that non-heme iron absorption from a light meal is promoted by a simultaneous intake of freeze-dried Lactobacillus plantarum 299v (Lp299v, DSM 9843).Study designWith a single blinded placebo controlled sequential design, iron absorption from a light breakfast meal administered with or without capsules containing 1010 cfu freeze-dried Lp299v was studied in healthy female volunteers of fertile age. The methodology used was a double isotope technique (59Fe and 55Fe). Two studies were performed using the same protocol.ResultsIn study 1, the absorption of iron from a meal without Lp299v was found to be 17.4 ± 13.4%, and from an identical meal with Lp299v was found to be 22.4 ± 17.3% (mean ± SD). This difference was statistically significant (p = 0.040, n = 14).In study 2, the absorption of iron from a meal without Lp299v was found to be 20.9 ± 13.1%, and from an identical meal with Lp299v found to be 24.5 ± 12.0% (mean ± SD, n = 28), which again was statistically significant (p = 0.003).ConclusionFreeze-dried Lp299v enhances the absorption of iron when administered together with a meal with a high iron bioavailability.Trial registrationClinicalTrials.gov Identifier: NCT02131870

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Capturing the onset of the common cold and its effects on iron absorption

Cited by 7 publications

References 18 publications

Serum hepcidin: indication of its role as an “acute phase” marker in febrile children

Serum hepcidin: indication of its role as an “acute phase” marker in febrile children

Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses

Freeze-dried Lactobacillus plantarum 299v increases iron absorption in young females—Double isotope sequential single-blind studies in menstruating women

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