Serum hepcidin: indication of its role as an “acute phase” marker in febrile children

Kossiva, Lydia; Soldatou, Alexandra; Gourgiotis, Dimitrios; Stamati, Lamprini; Tsentidis, Charalampos

doi:10.1186/1824-7288-39-25

Cited by 20 publications

(22 citation statements)

References 27 publications

(24 reference statements)

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“…The majority (5/7; 71%) of studies that evaluated ESR, a marker for inflammation found it to be a specific marker in differentiating between bacterial and non-bacterial infections [ 24 , 29 , 30 , 36 , 37 , 41 , 49 ]. Patients with bacterial infections had a higher ESR than patients with viral infections [ 30 ]; [ 49 ]; [ 29 , 36 , 37 ]. Two studies reported the diagnostic performance characteristics of ESR, which ranged from 77.4%-85% sensitivity and 78.3%-90% specificity to identify bacterial infections [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

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Host Biomarkers for Distinguishing Bacterial from Non-Bacterial Causes of Acute Febrile Illness: A Comprehensive Review

et al. 2016

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BackgroundIn resource limited settings acute febrile illnesses are often treated empirically due to a lack of reliable, rapid point-of-care diagnostics. This contributes to the indiscriminate use of antimicrobial drugs and poor treatment outcomes. The aim of this comprehensive review was to summarize the diagnostic performance of host biomarkers capable of differentiating bacterial from non-bacterial infections to guide the use of antibiotics.MethodsOnline databases of published literature were searched from January 2010 through April 2015. English language studies that evaluated the performance of one or more host biomarker in differentiating bacterial from non-bacterial infection in patients were included. Key information extracted included author information, study methods, population, pathogens, clinical information, and biomarker performance data. Study quality was assessed using a combination of validated criteria from the QUADAS and Lijmer checklists. Biomarkers were categorized as hematologic factors, inflammatory molecules, cytokines, cell surface or metabolic markers, other host biomarkers, host transcripts, clinical biometrics, and combinations of markers.FindingsOf the 193 citations identified, 59 studies that evaluated over 112 host biomarkers were selected. Most studies involved patient populations from high-income countries, while 19% involved populations from low- and middle-income countries. The most frequently evaluated host biomarkers were C-reactive protein (61%), white blood cell count (44%) and procalcitonin (34%). Study quality scores ranged from 23.1% to 92.3%. There were 9 high performance host biomarkers or combinations, with sensitivity and specificity of ≥85% or either sensitivity or specificity was reported to be 100%. Five host biomarkers were considered weak markers as they lacked statistically significant performance in discriminating between bacterial and non-bacterial infections.DiscussionThis manuscript provides a summary of host biomarkers to differentiate bacterial from non-bacterial infections in patients with acute febrile illness. Findings provide a basis for prioritizing efforts for further research, assay development and eventual commercialization of rapid point-of-care tests to guide use of antimicrobials. This review also highlights gaps in current knowledge that should be addressed to further improve management of febrile patients.

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Section: Resultsmentioning

confidence: 99%

“…Of the studies that evaluated inorganic molecules, chloride in CSF [ 21 , 28 ] and serum iron [ 36 ] reported statistically significant differences in the levels observed in bacterial versus non-bacterial infection patients. Chloride concentrations in CSF were compared in two meningitis studies, but the sensitivities differed greatly.…”

Section: Resultsmentioning

confidence: 99%

Host Biomarkers for Distinguishing Bacterial from Non-Bacterial Causes of Acute Febrile Illness: A Comprehensive Review

et al. 2016

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“…Park et al [15] found that patients showed high-level hepcidin in the acute infection stage after gastric resection, colon-liver resection, liver resection and operation for diffuse peritonitis. Kossiva et al [16] found in their clinical study that hepcidin was significantly increased in the acute phase of pediatric infectious fever, and there was no significant difference between the virus group and bacterial group.…”

Section: Discussionmentioning

confidence: 96%

Applied value of monitoring serum hepcidin in differential diagnosis of infection versus tumor fevers

Zhang

Zhao

et al. 2017

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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The applied value of serum hepcidin in differential diagnosis of infection fevers versus tumor fevers was explored. A total of 432 fever patients were selected according to the domestic fever of unknown origin (FUO) diagnostic criteria from our hospital between June 2010 and November 2013. Venous blood samples were taken on the day 1, 5, 10 after admission. The infection group (98 cases) and the tumor group (50 cases) were set up based on the clinical and laboratory findings. ELISA was used to determine the serum hepcidin and IL-6 levels. SPSS 13.0 was used for statistical analysis. Hepcidin showed obvious descending trend on the 10th day in both the bacterial infection group (66 cases) and the virus infection group (32 cases), and the descending trend was similar to that of inflammatory indexes such as procalcitonin (PCT), hypersensitive C-reactive protein (h-CRP), erythrocyte sedimentation rate (ESR), white blood cell (WBC), and ferritin. Serum hepcidin showed no obvious differences in the tumor group on the day 1, 5, 10 after admission. In the infection groups, serum hepcidin was positively correlated with IL-6 (r=0.687, P=0.000) and CRP (r=0.487, P=0.026), but had a poor correlation with blood sedimentation, ferritin, PCT and WBC (P>0.05). Monitoring dynamic changes of hepcidin and related inflammatory factors in patients with fever is expected to be used for clinical identification of infection fever and tumor fever.

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“…[51] IL-1 in association with the acute phase response also decreases plasma iron content and it is challenging to speculate that the sequestration of less deformable erythrocytes by endothelial cells in the spleen also plays a causative role in shortened halflife of erythrocytes thus, resulting in anemia. [52] Alternatively, a rise in both WBC and platelet counts might be due to the stimulation of immune system against the invading pathogenic microorganism and it is evident by the influx of inflammatory mononuclear cells in the joints of arthritic rats. [53,54] In the present experimental study, the herbal formulationtreated groups had considerably increased level of Hb and RBC, while the level of WBC and platelets was significantly reduced in contrast to arthritic control group but comparable to normal control group [ Table 6].…”

Section: Discussionmentioning

confidence: 99%

Untitled

Satyanarayana¹

2019

IJGP

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Objective: Rheumatoid arthritis (RA) is a systemic disorder which involves the activation of immune system against the self-tissues. The main targets of this disease are the joints. Being systemic, the development of this disease involves different mechanisms, and thus, the exact cause of this disease remains unknown. Although different drugs have been developed, none has been found to be the cure for this disease. The present study was commenced to evaluate the in vivo anti-arthritic effect of polyherbal formulation of selected plants Polygonum glabrum, Canthium dicoccum, Ochna obtusata, and Argyreia nervosa. Materials and Methods: In vivo anti-arthritic activity of the ethanolic extract of different portions capsule formulation F4 investigated orally was assessed using complete Freund's adjuvant-induced arthritis. Results: In complete Freund's adjuvant-induced arthritis models, the polyherbal extract formulations significantly (P < 0.001) reduced joint and paw swelling and markedly improved body weight, hematology profile, and parameters in complete Freund's adjuvant model. Conclusion: It could be concluded that the ethanolic extract of two different formulations holds anti-arthritic potential, supporting its traditional use in the treatment of RA.

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Serum hepcidin: indication of its role as an “acute phase” marker in febrile children

Cited by 20 publications

References 27 publications

Host Biomarkers for Distinguishing Bacterial from Non-Bacterial Causes of Acute Febrile Illness: A Comprehensive Review

Host Biomarkers for Distinguishing Bacterial from Non-Bacterial Causes of Acute Febrile Illness: A Comprehensive Review

Applied value of monitoring serum hepcidin in differential diagnosis of infection versus tumor fevers

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