Regulation of Erythropoiesis Xvi. Cytokinetic Patterns in Disorders of Erythropoiesis1

Stohlman, Frederick; Lucarelli, G; Howard, Donald; Morse, Bernard S.; Leventhal, Brigid G.; ERYTHEOPOIESIS, ADULT

doi:10.1097/00005792-196411000-00007

Cited by 53 publications

(20 citation statements)

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“…In PHZ-treated animals, 75% of the enzyme activity is lost during the first few days. This rapid decrease in enzyme activity is consistent with the finding that many of the cells formed during PHZ-induced erythropoiesis are destroyed shortly after their appearance in peripheral blood (30)(31)(32)(33)(34) (Fig. 7), indicates that the enzyme activity per cell is greater in reticulocytes formed during severe stress (2.0 or 3.0 mg of PHZ) than in those produced during moderate stress (1.0 mg of PHZ).…”

Section: Effect Of Friend Virus Infectionsupporting

confidence: 88%

“…Erythrocytes produced in rats, rabbits, and dogs after acute blood loss or PHZ-induced hemolysis are larger than normal red cells and have a greater mean corpuscular hemoglobin content (31,34,(51)(52)(53)(54)(55)(56)(57)(58)(59). It has been suggested that these macrocytes are produced as the result of a skipped mitosis during the maturation of the erythron (31,(52)(53)(54). Furthermore, the cells produced in response to anemia have been shown by cohort labeling to have a markedly shortened life span (30-34, 51, 56-58, 60-63).…”

Section: Effect Of Friend Virus Infectionmentioning

confidence: 99%

“…This occurs by the breakdown of RNA to low molecular weight products (76,79). During erythropoietic stress, erythroid development is characterized by a decreased marrow or spleen transit time (29,31,(80)(81)(82), which may be the result of shortened cell-cycle times (29,81,83) or of a reduction in the number of mitotic divisions (31,(52)(53)(54) or both (84). The loss of RNA might therefore occur during a shorter time period than in normal erythropoiesis.…”

Section: Effect Of Friend Virus Infectionmentioning

confidence: 99%

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Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse

Rothman¹,

Zanjani²,

Gordon³

et al. 1970

J. Clin. Invest.

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A B S T R A C T The level of nucleoside deaminase was determined in extracts of mouse tissues obtained during a period of accelerated erythropoiesis induced by hypoxia, hemorrhage, or the injection of phenylhydrazine. Under these conditions a striking (10-to 100-fold) elevation of the enzyme activity occurred in the spleen. Similar results were obtained with the injection of purified erythropoietin. In control animals, only a trace of nucleoside deaminase activity was detected in the blood. During the reticulocyte response which followed erythropoietic stimulation, there was a sharp increase in the blood level of nucleoside deaminase, which rose up to 120 times that of control animals. By differential centrifugation, the enzyme was localized to the reticulocyte-rich fraction. Erythrocyte nucleoside deaminase remained elevated even after the reticulocyte count had fallen to normal in the phenylhydrazine-treated mice or to zero after the cessation of hypoxia. There was a very gradual decline in the enzyme activity in the blood which fell to the barely detectable control levels about 45 days after the initial reticulocyte response, a time period which corresponds to the survival of the mouse red blood cell. The persistence of high levels of nucleoside deaminase for the full life span of a generation of erythrocytes formed during stress, viewed in contrast to the virtual absence of the enzyme from normal erythrocytes of all ages, represents an enzymatic difference between the normal red blood cell and the cell produced under conditions of accelerated erythropoiesis.

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Section: Effect Of Friend Virus Infectionsupporting

confidence: 88%

Section: Effect Of Friend Virus Infectionmentioning

confidence: 99%

Section: Effect Of Friend Virus Infectionmentioning

confidence: 99%

See 1 more Smart Citation

Nucleoside deaminase: an enzymatic marker for stress erythropoiesis in the mouse

Rothman¹,

Zanjani²,

Gordon³

et al. 1970

J. Clin. Invest.

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“…For example, such cells reportedly have a shortened life-span (15) and altered mean cell volume (16). This suggests that untimely departure from the marrow environment prevents continuation of the normal maturation process.…”

Section: Tests With Other Antibodiesmentioning

confidence: 99%

Red cell membrane alteration associated with "marrow stress".

Hillman¹,

Giblett²

1965

J. Clin. Invest.

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“…[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] (19)(20)(21)(22)(23)(24)(25)(26) * The values tabulated are the means of the last determinations before discontinuing phlebotomy or phenylhydrazine administration; the figures in parentheses refer to observed range. 3%7o or less within 4 days in both animals.…”

mentioning

confidence: 99%