Regulation of colony-stimulating factor 1 during pregnancy.

Bartocci, A.; Pollard, Jeffrey W.; Stanley, E. Richard

doi:10.1084/jem.164.3.956

Cited by 298 publications

(132 citation statements)

References 17 publications

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“…RNA was isolated from placental homogonates of ϩ/Csf1 op mice (two mice per time point) from days 9, 10, 12, 14, 15, 16, and 17 of pregnancy. Northern analysis for IDO mRNA (1.56 kb) shows that IDO mRNA peaks at day 10 of pregnancy and declines to below the level of detection by day 15. IDO mRNA levels, as shown in the line graph, were normalized to ␤-actin.…”

Section: Placental Ido Expression During Normal Pregnancymentioning

confidence: 99%

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Indoleamine 2,3-Dioxygenase Is Regulated by IFN-γ in the Mouse Placenta DuringListeria monocytogenesInfection

Mackler¹,

Barber²,

Takikawa

et al. 2003

The Journal of Immunology

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The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) is expressed in macrophages that have been differentiated in the presence of CSF-1 and is important in the containment of intracellular pathogens. IDO also appears to play a role in suppression of T cell responses in a variety of contexts. In the placenta, its enzymatic activity is believed to establish a chemical barrier that protects the fetal allograft from T cell-mediated immune aggression. We have studied the regulation of IDO in the utero-placental unit of mice following infection with the Gram-positive, intracellular bacterium Listeria monocytogenes that has a predilection for replication in the decidua basalis. IDO mRNA and protein expression is enhanced in the utero-placental unit following infection with L. monocytogenes. However, in contrast to the human where IDO is expressed by the CSF-1R-positive syncytial trophoblast, IDO is not expressed in murine trophoblastic tissue but instead is found in stromal cells of the decidua basalis and metrial gland and following infection, in endothelial cells. Using mice carrying null mutations in cytokine/growth factor genes, we explored the regulation of IDO in the placenta. Consistent with the absence of CSF-1R expression in the IDO-expressing cells of mice, neither the basal levels of IDO nor its induction following infection is affected by the absence of CSF-1. However, although the basal level of IDO is normal, the enhanced expression during Listeriosis is completely abrogated in the absence of IFN-γ, a cytokine required for the resolution of this infection. These data suggest that IDO plays a role in resolving bacterial infection in the placenta while at the same time maintaining a barrier to T cells whose presence might result in fetal rejection.

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Section: Placental Ido Expression During Normal Pregnancymentioning

confidence: 99%

“…CSF-1, the primary growth factor for macrophages, is synthesized to very high concentrations at the maternal-fetal interface by the uterine epithelium (15,16). Apart from the macrophages present in the undecidualized stroma, trophoblast express the CSF-1R suggesting that these are also target cells.…”

mentioning

confidence: 99%

Indoleamine 2,3-Dioxygenase Is Regulated by IFN-γ in the Mouse Placenta DuringListeria monocytogenesInfection

Mackler¹,

Barber²,

Takikawa

et al. 2003

The Journal of Immunology

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“…In vivo animal studies, using ['25I]CSF-l as tracer, showed the half-life of CSF-I in the circulation to be approximately 10 min . During pregnancy the very high uterine synthesis of CSF-1 may contribute to the slightly elevated circulating CSF-I concentration (Bartocci et al, 1986;Pollard et al, 1987). Modest elevations in the circulating CSF-1 concentration are evident in disease states such as myeloproliferative disorders (Gilbert et al, 1989;Janowska-Wieczorek et al, 1991) and in ovarian cancer patients, in whom they were highly correlated with the presence of active disease (Kacinski et al, 1989a Cox (1972).…”

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confidence: 99%

Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer

Scholl

Bascou²,

Mosseri³

et al. 1994

Br J Cancer

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Summary Serum samples from 82 patients with epithelial ovarian cancer, previously assayed for CA125, were assayed for circulating colony-stimulating factor 1 (CSF-1). An elevated CSF-1 concentration (>450 U ml-' or >5.42 ng ml-') was significantly associated with a worse survival (P = 0.02). The predictive value of raised CSF-1 levels was retained whether the first available sample for all patients (n = 82) or the first sample at the start of chemotherapy (n = 41) was considered. Mean CSF-1 levels (n = 14) dropped significantly during six courses of platinum-based chemotherapy (P= 0.02). Although an elevated CA125 concentration appeared to be a prognostic indicator in the total population (n = 82), it was not related to prognosis in the group of patients from whom samples had been drawn at the start of chemotherapy. In a Cox proportional hazards model, CSF-1, but not CA125, was significantly associated with outcome following adjustment for stage, grade and degree of surgical clearance.

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“…Female homozygous M-CSF-deficient osteopetrotic (op/op) mutant mice exhibit greatly reduced rates of fertility; however, successful pregnancy is not completely blocked [22]. M-CSF is synthesized in the uterus of pregnant mice, and the uterine M-CSF concentration increases 1,000-fold by term [2,21,25]. Expression of the gene encoding M-CSF is first detected in the mouse uterine epithelium prior to implantation on day 3 of pregnancy and subsequently increases, reaching a peak at day 14 or 15 of pregnancy [1].…”

mentioning

confidence: 99%

Concentration of Macrophage Colony-Stimulating Factor (M-CSF) in Bovine Peripheral Blood during Pregnancy

Oshima

Kojima

Komatsu

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. Macrophage colony-stimulating factor (M-CSF) is a hemopoietic cytokine with a primary role in placental physiology. Gene expression of M-CSF in the bovine endometrium shows a temporal upward trend during early and mid pregnancy. This study determined the plasma M-CSF levels during pregnancy using ELISA. In experiment 1, to investigate the relationship between the concentration of M-CSF in peripheral blood and pregnancy, the plasma M-CSF levels were determined in 125 pregnant and 21 non-pregnant Japanese Black cows. The pregnant animals were divided into nine groups based on the month of pregnancy. An ELISA for bovine M-CSF established previously was used according to the authors' instructions. In experiment 2, the plasma M-CSF level was determined to investigate the temporal changes in its concentration in the peripheral blood during pregnancy. In experiment 1, the plasma M-CSF level varied from month to month during pregnancy; the mean level in the first-month of pregnancy was significantly higher than those in the third and last months of pregnancy and non-pregnancy (P<0.05). In experiment 2, the plasma M-CSF level varied with the day of pregnancy (P<0.05). The mean level of plasma M-CSF decreased gradually until 6 weeks of pregnancy; it appeared to increase during weeks 7-9, then varied with several small peaks until 27 weeks of pregnancy and finally decreased gradually until parturition. These results suggest that the plasma M-CSF level may be related to changes in the uterus and placenta as pregnancy progresses.

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Regulation of colony-stimulating factor 1 during pregnancy.

Cited by 298 publications

References 17 publications

Indoleamine 2,3-Dioxygenase Is Regulated by IFN-γ in the Mouse Placenta DuringListeria monocytogenesInfection

Indoleamine 2,3-Dioxygenase Is Regulated by IFN-γ in the Mouse Placenta DuringListeria monocytogenesInfection

Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer

Concentration of Macrophage Colony-Stimulating Factor (M-CSF) in Bovine Peripheral Blood during Pregnancy

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