Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer

Scholl, Susy; Bascou, C.; Mosseri, Véronique; Olivares, Robert; Magdelénat, H.; Dorval, Thierry; Palangié, T; Validire, Pierre; Pouillart, P; Stanley, E. Richard

doi:10.1038/bjc.1994.62

Cited by 63 publications

(44 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No significant changes in serum M-CSF levels were observed in ovarian tumor tissue samples collected both prior to and at the end of surgery (Scholl et al 1994). On the other hand, significant decreases in M-CSF levels were observed in serial determinations during chemotherapy.…”

Section: Cytokines As Tumor Markers In Ovarian Cancer Patientsmentioning

confidence: 77%

“…Even though no definite correlation between M-CSF and CA 125 has been found by several authors (Xu et al 1991, Scholl et al 1994Suzuki et al 1993Suzuki et al , 1995, it seems that the combined determination of these two markers can lead to an improvement in overall sensitivity, especially in stage I ovarian cancer patients (Suzuki et al 1993).…”

Section: Cytokines As Tumor Markers In Ovarian Cancer Patientsmentioning

confidence: 99%

See 1 more Smart Citation

The role of cytokines in both the normal and malignant ovary.

Nash

Ferrandina²,

Gordinier³

et al. 1999

Endocrine-Related Cancer

108

View full text Add to dashboard Cite

Normal ovarian tissue is rich in cytokines. Cytokines and chemokines are important in the physiology of ovarian function and of ovulation. Cytokines and chemokines may recruit cytokine-producing lymphocytes to the site of a developing follicle, and cytokines appear to play an important role in pre and post follicle development.Most of the same cytokines that are found in normal ovarian tissue are also found in association with malignancy in contrast to their functions in normal tissues. It is reasonable to assume that the functions of cytokines associated with malignancy may serve to promote the unregulated growth if tumor cells and metastasis. It is also likely that cytokines produced by tumors will modulate immune responses that favor tumor progression.In the following review, we have highlighted those functions of cytokines that have been identified as having the most significant impact on tumor growth and development. By examining activities of these cytokines in normal and in malignant ovarian tissues, it is hoped that future possible avenues for investigation may be opened up and that the results of these investigations will lead to strategies that can modulate the production or the activity of the cytokines leading to the growth of tumors or their metastases. Such strategies now fall under the general discipline of bioimmunotherapy. This is an expanding discipline as more is learned about growth regulation in cancer, and with the availability Endocrine-Related Cancer (1999) 6 93-107 and rapid development of new molecules for therapeutic approaches

show abstract

Section: Cytokines As Tumor Markers In Ovarian Cancer Patientsmentioning

confidence: 77%

Section: Cytokines As Tumor Markers In Ovarian Cancer Patientsmentioning

confidence: 99%

The role of cytokines in both the normal and malignant ovary.

Nash

Ferrandina²,

Gordinier³

et al. 1999

Endocrine-Related Cancer

108

View full text Add to dashboard Cite

show abstract

“…70 It has been also suggested that M-CSF released by murine sarcoma cells may mediate the induction of macrophage-derived tumor growth factors. 71 Enhanced serum levels of M-CSF in patients with ovarian carcinoma 72 and non-small cell lung carcinoma 20 were found to correlate with patients poor prognosis. Our results suggest that M-CSF serum assays are of rather limited value in predicting soft tissue sarcoma patients outcomes.…”

Section: Cytokine Serum Levels During Follow-upmentioning

confidence: 99%

Cytokine serum levels in soft tissue sarcoma patients: Correlations with clinico‐pathological features and prognosis

Rutkowski

Kamińska

Kowalska

et al. 2002

Intl Journal of Cancer

View full text Add to dashboard Cite

We investigated the correlations between serum levels of selected proinflammatory, hematopoietic and angiogenic cytokines and soluble cytokine receptors with the clinicopathological features and prognosis in soft tissue sarcoma patients. Serum levels of 9 cytokines (TNF␣, IL-1ra, IL-6, IL-8, IL-10, M-CSF, G-CSF, VEGF, bFGF) and 4 free cytokine receptors (sIL-2R␣, sIL-6R, TNFRI, TNFRII) were measured by means of an enzyme-linked immunoadsorbent assay kit in 156 soft tissue sarcoma patients before the treatment and in 50 healthy controls. Serum levels of 10 cytokines and cytokine receptors were also assayed during patients' follow-up after the treatment. Significantly elevated pretreatment serum levels of 11/13 cytokines and cytokine receptors were found in sarcoma patients, as compared to healthy controls.

show abstract

“…Despite extensive research, the mortality does not seem to be decreasing (Bourne et al, 1993). However, even in patients presenting with early disease, an extensive surgical treatment does not guarantee cure (Scholl et al, 1994). Therefore, new variables correlating with the malignant potential of the cancer cells would be clinically valuable in adjuvant therapy for individual patients in early stage ovarian cancer.…”

mentioning

confidence: 99%

Expression of the thymidine phosphorylase gene in epithelial ovarian cancer

et al. 1999

View full text Add to dashboard Cite

Summary Thymidine phosphorylase (TP) is associated with angiogenesis and the progression of solid tumours. High intracellular levels of this enzyme indicate increased chemosensitivity to pyrimidine antimetabolites. TP gene expression in 56 cases of epithelial ovarian cancer (27 of serous, 10 mucinous, 12 endometrioid, five clear cell and two undifferentiated) were analysed by polymerase chain reaction of RNA after reverse transcription. These included eight of low malignant potential. Twenty were stage I, four stage II, 27 stage III and five stage IV. The level of TP gene expression was presented by the relative yield of the TP gene to the β2-microglobulin gene. TP gene expression ranged from 0.19 to 5.38 (median 0.93). The value of TP gene expression in stage III-IV was significantly higher than that of TP gene expression in stage I-II (P = 0.0005). Histological grade significantly associated with TP gene expression (P = 0.008), but histological subtype did not (P = 0.166). A follow-up study of 34 cases after complete resection of the primary tumours by surgical operation was performed. TP gene expression of the cases with recurrence showed significantly higher levels compared to cases without recurrence (P = 0.049). Survival data were available for 47 of the 56 patients. The prognosis of the patients with high TP gene expression (equal to, or greater than, median) was to be significantly worse than patients with low TP gene expression (less than median) (P = 0.021). The TP gene expression level may play one of the key roles in the biology of ovarian epithelial cancer and define a more aggressive tumour phenotype. A new therapeutic intervention mediated by TP protein activity is anticipated.

show abstract

Circulating levels of colony-stimulating factor 1 as a prognostic indicator in 82 patients with epithelial ovarian cancer

Cited by 63 publications

References 31 publications

The role of cytokines in both the normal and malignant ovary.

The role of cytokines in both the normal and malignant ovary.

Cytokine serum levels in soft tissue sarcoma patients: Correlations with clinico‐pathological features and prognosis

Expression of the thymidine phosphorylase gene in epithelial ovarian cancer

Contact Info

Product

Resources

About