Regulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone

Fraser, David R.; Kodíček, E.

doi:10.1038/newbio241163a0

Cited by 451 publications

(153 citation statements)

References 26 publications

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“…MacIntyre et al (1974) conversely showed that PTH inhibited 1,25-(OH)2Dain intact rats on a high calcium diet. Fraser and Kodicek (1973) obtained similar results in experiments with parathyroidectomised chicks. Rasmussen et al (974) and Larkins et al (1974) stimulated 1,25-(OHhDa production in isolated renal tubules with both PTH and its intracellular messenger cyclic AMP.…”

Section: B the Role 0/ Calciostatic Hormonessupporting

confidence: 76%

Metabolism of Vitamin D

Atkins

Martin

1976

Ann Clin Biochem

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Section: B the Role 0/ Calciostatic Hormonessupporting

confidence: 76%

Metabolism of Vitamin D

Atkins

Martin

1976

Ann Clin Biochem

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“…The transformation of 25-hydroxycholecalciferol to the active form 1,25(OH) 2 D 3 has been reported to be facilitated by the parathyroid hormone (RASMUSSEN et al,1972, FRASER andKODICEK, 1973). Also, increased calcium ions can inhibit this transformation by the direct action on the parathyroid and calcitonin secretion rates (BOYLE et al, 1971).…”

Section: Discussionmentioning

confidence: 99%

1,25(OH)2D3 Induced Alterations in Plasma Calcium, Inorganic Phosphate, Ultimobranhial Gland and Parathyroid Gland of the Garden Lizard, Calotes Versicolor

Srivastava¹,

Mishra²,

Srivastav³

et al. 2008

Zoologica Poloniae

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Abstract. Garden lizards Calotes versicolor were procured and given daily intraperitoneal injections of 30 pmol of 1,25(OH) 2 D 3 /50 g body wt for 30 days. Lizards were sacrificed on the 1 st , 3 rd , 5 th , 10 th , 15 th and 30 th day of the experiment. The plasma calcium levels of C. versicolor remain unaffected after day 1 following 1,25(OH) 2 D 3 treatment. After day 3 the levels increase significantly which progresses up to day 10. Thereafter, the plasma calcium level tends to decrease on day 15 and the levels become normal at day 30. In 1,25(OH) 2 D 3 injected lizards the plasma inorganic phosphate levels remain unaltered up to day 3. After day 5, the value increases significantly. This increase progresses up to day 15. On day 30, the levels become almost normal. The ultimobranchial gland exhibits hyperactivity following 5 day 1,25(OH) 2 D 3 treatment which is expressed by an increase in the nuclear volume and weak staining response of the cytoplasm of ultimobranchial cells. After day 10, the nuclear volume is further increased and some of the cells are exhausted. Following 15 days 1,25(OH) 2 D 3 treatment the nuclear volume records an increase and many degenerating cells are discerned. After day 30, the nuclear volume is almost normal, most cells seem to be recovered and only a few degenerating cells are noticed. After day 10 and day 15 following 1,25(OH) 2 D 3 treatment, the parathyroid glands of C. versicolor show reduced chromaticity of nuclei and a progressive decrease in the nuclear volume of parathyroidal cells. On day 30, the nuclear volume tends to become normal and a few degenerating cells are observed.

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“…A number of studies suggest that in the vitamin D-deficient state the plasma concentration of calcium might feed-back regulate the production of 1,25-(OH)2D3 through the parathyroid system (10)(11)(12)(13)(14). In vitamin D-deficient rats, the production of 1,25-(OH)2D3 was greater during hypocalcemia than during normocalcemia (induced by high calcium diets) (10).…”

Section: 25-dihydroxyvitamin D3 [125-(oh)2d3]p Is the Mostmentioning

confidence: 99%

“…It was concluded that parathyroid hormone (PTH) may be a trophic hormone that stimulates the production of 1,25-(OH)2D3 (12). In 4-wk-old chicks raised on a vitamin D-deficient diet but supplemented with vitamin D 16-18 h before parathyroidectomy (PTX), 25-OHD3-la-hydroxylase activity was decreased at 13 and 14 h after PTX (13). Accordingly, Fraser and Kodicek concluded that 25-OHD3-lahydroxylase is regulated and stimulated by circulating PTH (13 (11,13,(16)(17)(18).…”

Section: 25-dihydroxyvitamin D3 [125-(oh)2d3]p Is the Mostmentioning

confidence: 99%