The present study was aimed to explore the KAP (knowledge, attitude and practice) adopted by the university students of Madhya Pradesh (India) towards prevention of Covid-19 pandemic. For this purpose, authors performed an online survey with 776 students using a selfdesigned semi-structured questionnaire. The results found that students had a moderate to a high level of knowledge about the Covid-19 and sufficient knowledge regarding its preventive measures. The authors could not found any significant correlation between attitude and the socio-demographic variable (sex, age, qualification, and level of education) at (p < 0.05). The majority of the respondents admitted that they always wore a face mask and adopted the practice of going to crowded places and washing their hands with soap or sanitizer before and after touching of objects and suspicious people. In conclusion, authors found that more than two-third of university students have adequate knowledge of the Covid-19. Authors could not detect any statistically significant difference in the level of knowledge about Covid-19 among the participants irrespective of their academic qualifications. Authors suggest conducting follow up studies involving teaching and non-teaching staff in the schools and colleges of the state and country.
Indole-3-carbinol (I3C) is present in many cruciferous vegetables and is known to possess protective properties against chemically induced toxicity and carcinogenesis. In the present study, the antimutagenic potential of I3C has been evaluated using in vivo chromosomal aberration (CA) assay as a cytogenetic end point. Chromosomal analysis was carried out in mouse bone marrow cells following administration of I3C (5 mg/kg; i.p.) for 5 consecutive days. Cyclophosphamide (CP), a well known mutagen, was given at two dose levels of 25 mg/kg b.wt. and 100 mg/kg b.wt., respectively, 24 hours prior to the last dose of I3C. Two groups of five mice each were also injected with CP (25 or 100 mg/kg b.wt.) alone whereas for the vehicle control a group of mice was injected with normal saline only. The results revealed a significant inhibition in the frequencies of CP-induced CAs and aberrant cells in bone marrow cells of I3C-supplemented Swiss albino mice. The antimutagenic potential of I3C towards CP was also evident as the status of mitotic index (MI) was found to show an increment. This study revealed the antigenotoxic potential of I3C against CP- induced chromosomal mutations.
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