Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine

Wang, Tao; Zhang, Deqin; Li, Yuhong; Liu, Hong; Zhanbiao, Liu; Zhao, Chunfeng; Hu, Limin; Gao, Xiumei

doi:10.1016/j.jep.2010.01.044

Cited by 55 publications

(43 citation statements)

References 21 publications

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“…27 There are studies that have used plants for treatment or prevention of hyperlipidemias: soy, 28 green tea, 29 Malpighia emarginata, 30 and Ananas comosus. 2 Tao et al 31 showed significant reduction in glycemia, cholesterol, and triglycerides by using a traditional antidiabetic formula prepared with many plants. Adeneye and Adeyemi 32 found a decrease in lipids and glycemia after using Hunteria umbellata.…”

Section: Discussionmentioning

confidence: 99%

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

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The aim of this study was to evaluate the effects of Passiflora edulis f. flavicarpa Degener (yellow passion) juice on the lipid profile and oxidative stress status of Wistar rats. Adult male Wistar rats were divided in two groups (n = 8 animals per group): the control group, which received water, and the treated group, which was given P. edulis juice (1,000 mg/kg). Both groups received by gavage treatment twice a day for 28 days. The treated group showed an increased high-density lipoproteincholesterol level and decreased low-density lipoprotein-cholesterol and free fatty acid levels compared with the control group. Levels of triglycerides and and very low-density lipoprotein-cholesterol, superoxide dismutase activity, and total glutathione concentration were not statistically different between the two groups, but the thiobarbituric acid-reactive substances concentration (indicating lipid peroxidation) decreased in the treated group. These findings suggests that P. edulis juice in the experimental conditions used showed beneficial effects on lipid profile and improved lipid peroxidation in Wistar rats.

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Section: Discussionmentioning

confidence: 99%

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

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show abstract

“…Umar et al 20 observed that Tetracera scandens had antidiabetic efficacy in diabetic rats. Tao et al 21 showed significant reduction in glucose, cholesterol, and triglyceride levels by using a traditional antidiabetic formula prepared with many plants. Salahuddin and Jalalpure 22 observed a reduction in blood glucose levels and a reduction in lipid profile after using extract of Curcumis trigonus in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring

Barbalho

Damasceno

Spada

et al. 2011

Journal of Medicinal Food

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Dry extract of the genus Passiflora has been shown to help control glycemia and lipid levels. The objective of this study was to evaluate the effects of passion fruit (P. edulis) on the biochemical profile of offspring from diabetic rats. Diabetes was induced by streptozotocin. The diabetes group consisted of 10 rats with glucose levels greater than 200 mg/dL; the nondiabetic (control) group consisted of 10 rats with glucose levels less than 120 mg/dL. After the diagnosis of diabetes, the mating phase was started. By day 21 of pregnancy, the offspring were born; the dams were kept in individual cages with their offspring until the weaning period. The offspring were then divided into 4 groups (n = 15 each): G1 were offspring from control dams, G2 were offspring from treated nondiabetic dams, G3 were offspring from diabetic dams, and G4 were offspring from treated diabetic dams. For 30 consecutive days, G1 and G3 offspring were treated with vehicle (oral gavage) and G2 and G4 offspring were treated with passion fruit juice (oral gavage). After 30-day treatment, the animals were anesthetized and killed, and blood was drawn immediately for analysis of the biochemical profile (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and glucose). The G2 and G4 rats showed significantly reduced total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and an increased high-density lipoprotein cholesterol level. The use of passion fruit juice improved lipid profiles, suggesting that this plant may have beneficial effects in the prevention and treatment of dyslipidemias and hyperglycemia.

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“…The voucher specimen was deposited at the Academy of Traditional Chinese Medicine (TCM) of Tianjin University of TCM (No.20071016-3). The hawthorn leaves extract preparation and qualification were the same as described before [17].…”

Section: Plant Materialsmentioning

confidence: 99%

“…Our previous pharmacological studies found that the hawthorn leaves flavonoid fractions strongly inhibited alpha-glucosidase, lipase together with a free radical scavenging activity [17]. As a continuing bioactive study, we have evaluated the prevention effect of hawthorn extracts on selenite-induced cataractogenesis.…”

Section: Introductionmentioning

confidence: 99%

Prevention Effect in Selenite-Induced Cataract in Vivo and Antioxidative Effects in Vitro of Crataegus pinnatifida Leaves

Wang

Zhang

Zhao³

et al. 2010

Biol Trace Elem Res

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Cataract is the leading cause of blindness worldwide. It is a multifactorial disease primarily associated with oxidative stress produced by free radicals. The present study was undertaken to evaluate the anticataract potential of Crataegus pinnatifida (hawthorn tree) leaves extract in selenite-induced cataract in vivo and antioxidant effects in vitro. In vitro antioxidant assay of C. pinnatifida leaves extract on NO production inhibition, aldose reductase inhibition, and O(2)(-) radical scavenging activities gave the IC(50) of 98.3, 89.7, and 5.98 μg/mL, respectively. To characterize some major compounds in C. pinnatifida leaves extract, nine flavonoids were identified via LC-MS/MS qualitative analysis. Based on in vitro screening results, C. pinnatifida leaves extract eye drops in 0.1% hydroxypropyl methyl cellulose solution were prepared to evaluate the anticataract potential in vivo. Administration of C. pinnatifida leaves extract eye drops alternately three times a day in rat pups with selenite-induced oxidative stress significantly increased serum SOD and CAT activities, and tended to reduce MDA level compared with control group. The antioxidant enzyme SOD, CAT, and GSH activities in lens showed a significant increase. These results may be applied in the future for the prevention and treatment of cataracts.

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Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine

Cited by 55 publications

References 21 publications

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring

Prevention Effect in Selenite-Induced Cataract in Vivo and Antioxidative Effects in Vitro of Crataegus pinnatifida Leaves

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