Effects of Passiflora edulis on the Metabolic Profile of Diabetic Wistar Rat Offspring

Abstract

Dry extract of the genus Passiflora has been shown to help control glycemia and lipid levels. The objective of this study was to evaluate the effects of passion fruit (P. edulis) on the biochemical profile of offspring from diabetic rats. Diabetes was induced by streptozotocin. The diabetes group consisted of 10 rats with glucose levels greater than 200 mg/dL; the nondiabetic (control) group consisted of 10 rats with glucose levels less than 120 mg/dL. After the diagnosis of diabetes, the mating phase was started. By day 21 of pregnancy, the offspring were born; the dams were kept in individual cages with their offspring until the weaning period. The offspring were then divided into 4 groups (n = 15 each): G1 were offspring from control dams, G2 were offspring from treated nondiabetic dams, G3 were offspring from diabetic dams, and G4 were offspring from treated diabetic dams. For 30 consecutive days, G1 and G3 offspring were treated with vehicle (oral gavage) and G2 and G4 offspring were treated with passion fruit juice (oral gavage). After 30-day treatment, the animals were anesthetized and killed, and blood was drawn immediately for analysis of the biochemical profile (total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and glucose). The G2 and G4 rats showed significantly reduced total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and an increased high-density lipoprotein cholesterol level. The use of passion fruit juice improved lipid profiles, suggesting that this plant may have beneficial effects in the prevention and treatment of dyslipidemias and hyperglycemia.

Effects of <i>Pereskia aculeata</i> Miller on the Biochemical Profiles and Body Composition of Wistar Rats

“…Braga et al (2010) [30] investigated the anti-hyperglycemic activity of Passiflora edulis Sims peel flour in diabeticmice and found a significant decrease in blood glucose levels, demonstrating the anti-hyperglycemic action of passion fruit peel flour. [31], who also used Passiflora edulis Sims, observed beneficial effects on serum glucose levels.…”

Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology

“…Passion fruit plays an important role in preventing hyperlipidemia. The passion fruit juice at a dose of 580 mg/kg once a day for 30 consecutive days significantly reduced total cholesterol, triglyceride, and lowdensity lipoprotein cholesterol levels, and increased highdensity lipoprotein cholesterol level in diabetic Wistar rat offspring (Barbalho et al, 2011), and peel flour of P. edulis counteracted cumulative body weight gain, decreased adiposity and leptin level, increased adiponectin in diet-induced obesity in rat (Lima et al, 2016). Oral administration of pectin from P. edulis fruit peel 0.5-25 mg/kg for 5 days effectively decreased triglyceride levels in diabetic rats (Silva et al, 2011), and the insoluble fiber derived from seed of P. edulis decreased serum triglyceride and total cholesterol, liver cholesterol, and increased the cholesterol, total lipids, and bile acids levels in feces of golden Syrian hamsters (Chau and Huang, 2005).…”

Passiflora edulis: uma breve revisão dos efeitos antidiabéticos

“…Barbalho et al 23 e Souza et al 24 encontraram que a utilização do suco da P. edulis melhorou o perfil lipídico de ratos Wistar, mostrando efeito benéficos na prevenção e no tratamento de dislipidemias e hiperglicemia.…”