Regulating of cell cycle progression by the lncRNA CDKN2B-AS1/miR-324-5p/ROCK1 axis in laryngeal squamous cell cancer

Liu, Feifei; Xiao, Yang; Ma, Li; Wang, Jun

doi:10.1177/1724600819898489

Cited by 19 publications

(16 citation statements)

References 30 publications

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“…The relationship between miR-324-5p and ANRIL has been investigated in laryngeal squamous cell cancer, in which highly expressed ANRIL promoted overall survival, advanced clinical stage, and lymph node metastasis. 11 Consistent with previous studies, 11 our study revealed that the modulation of ANRIL on ovarian cancer was mediated by sponging miR-324-5p. Most of the aforementioned studies demonstrated that miR-324-5p suppressed cell growth and migration.…”

Section: Discussionsupporting

confidence: 91%

“… 28 miR-324-5p was proved to exert tumor-suppressive functions. 29 Decreased miR-324-5p was observed in laryngeal squamous cell cancer, 11 lung cancer, 30 , 31 breast cancer, 32 gastric cancer, 33 cervical cancer, 34 bladder cancer, 35 and colon cancer. 36 , 37 miR-324-5p inhibited the Warburg effect and repressed tumorigenesis of ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

“…A study confirmed that ANRIL was upregulated while miR-324-5p was down-regulated in laryngeal squamous cell cancer. 11 Of note, the effect of the ANRIL/miR-324-5p axis on ovarian cancer was unclear, which might be similar to that in laryngeal squamous cell cancer. According to the TargetScan prediction of RNA action sites, Ran was considered as a target of miR-324-5p.…”

Section: Introductionmentioning

confidence: 99%

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LncRNA ANRIL Regulates Ovarian Cancer Progression and Tumor Stem Cell-Like Characteristics via miR-324-5p/Ran Axis

Wang¹,

Hu²,

Zhao³

et al. 2021

OTT

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LncRNA ANRIL Regulates Ovarian Cancer Progression and Tumor Stem Cell-Like Characteristics via miR-324-5p/Ran Axis

Wang¹,

Hu²,

Zhao³

et al. 2021

OTT

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“…18 LncRNA CDKN2B-AS1 sponges miR-324-5p to regulate cell-cycle progression in laryngeal squamous cell cancer. 19 Previous studies also revealed LINC00173 was a sponge for some miRNAs, such as miR-490-3p and miR-218. 13,14 In our study, we did not observe LINC00173 sponges above miRNAs.…”

Section: Dovepressmentioning

confidence: 98%

<p>Long Noncoding RNA LINC00173 Promotes NUTF2 Expression Through Sponging miR-765 and Facilitates Tumorigenesis in Glioma</p>

Du¹,

Liu²,

Tian³

et al. 2020

CMAR

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Background: Glioma is one of the leading causes of cancer-related deaths. This study aimed to investigate the function and mechanism of long noncoding RNA (lncRNA) LINC00173 in the regulation of glioma progression. Methods: LINC00173 expression was measured using qRT-PCR. Survival rate was analyzed through Kaplan-Meier method. CCK8, colony formation and EdU assays were performed to measure cell proliferation while transwell was used to determine cell migration and invasion. Luciferase reporter assay was conducted to test RNA interaction. Results: LINC00173 expression was elevated in glioma tissues and cells. LINC00173 high expression predicted poor prognosis. Loss of LINC00173 inhibited proliferation, migration and invasion. LINC00173 interacted with miR-765 to enhance NUTF2 expression. MiR-765 expression was negatively correlated with LINC00173 and NUTF2 in glioma tissues. NUTF2 level was increased in glioma tissues. NUTF2 overexpression rescued the potential of proliferation, migration and invasion in LINC00173-silenced cells. Conclusion: Our research demonstrated that LINC00173 promotes glioma progression through targeting miR-765/NUTF2 axis.

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“…lncRNA CDKN2B antisense RNA 1 (CDKN2B-AS1), which is an antisense of the cyclin-dependent kinase inhibitor 2B (CDKN2B), plays important roles in various diseases including in cancers [15][16][17][18] . Zhu et al reported that interference of CDKN2B-AS1 restrains the metastasis and promotes apoptosis and senescence of cervical cancer cells via regulating miR-181a-5p/TGFβI axis.…”

Section: Introductionmentioning

confidence: 99%

<p>LncRNA CDKN2B-AS1 Promotes Cell Viability, Migration, and Invasion of Hepatocellular Carcinoma via Sponging miR-424-5p</p>

Shen¹,

Yong²,

He³

et al. 2020

CMAR

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Objective: Hepatocellular carcinoma (HCC) results in high mortality and metastasis. In this study, the effects of long non-coding RNA (lncRNA) CDKN2B-AS1 on the progression of HCC were investigated. Materials and Methods: LncRNA CDKN2B-AS1 expression of HCC cancer and adjacent tissues, and HCC cells were detected. Subsequently, CDKN2B-AS1 was overexpressed and silenced in HCC cells to observe the effects of CDKN2B-AS1 on the cell viability, migration, invasion, and epithelial-mesenchymal transition (EMT) of HCC cells by performing cell counting kit-8 (CCK-8), wound-healing, Transwell, and Western blot. The target gene of CDKN2B-AS1 was predicted and verified to be miR-424-5p, whose expression in HCC cells with up-or down-regulation of CDKN2B-AS1 expression was determined. Moreover, the effects of miR-424-5p on cell viability, migration, and invasion and EMT of HCC cells were investigated with miR-424-5p up-regulation or down-regulation, together with overexpression or silencing of CDKN2B-AS1. Results: CDKN2B-AS1 expression was increased in HCC tissues and cells. Silencing of CDKN2B-AS1 suppressed cell viability, migration, invasion, and EMT, while overexpression of CDKN2B-AS1 produced the opposite results. Furthermore, CDKN2B-AS1 was predicted and verified to target miR-424-5p and was confirmed to negatively modulate miR-424-5p expression. Moreover, overexpression of miR-424-5p partially suppressed the previously high cell viability, migration, and invasion, and activated EMT resulted from upregulation of CDKN2B-AS1, while silencing of miR-424-5p elevated the cellular processes inhibited by silencing the expression of CDKN2B-AS1. Conclusion: The present study revealed that high-expressed CDKN2B-AS1 may associate with the progression of HCC by affecting the cell viability, migration, invasion, and EMT of HCC cells by negatively regulating miR-424-5p.

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Regulating of cell cycle progression by the lncRNA CDKN2B-AS1/miR-324-5p/ROCK1 axis in laryngeal squamous cell cancer

Cited by 19 publications

References 30 publications

LncRNA ANRIL Regulates Ovarian Cancer Progression and Tumor Stem Cell-Like Characteristics via miR-324-5p/Ran Axis

LncRNA ANRIL Regulates Ovarian Cancer Progression and Tumor Stem Cell-Like Characteristics via miR-324-5p/Ran Axis

<p>Long Noncoding RNA LINC00173 Promotes NUTF2 Expression Through Sponging miR-765 and Facilitates Tumorigenesis in Glioma</p>

<p>LncRNA CDKN2B-AS1 Promotes Cell Viability, Migration, and Invasion of Hepatocellular Carcinoma via Sponging miR-424-5p</p>

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