&lt;p&gt;LncRNA CDKN2B-AS1 Promotes Cell Viability, Migration, and Invasion of Hepatocellular Carcinoma via Sponging miR-424-5p&lt;/p&gt;

Shen, Xiu‐Yu; Yong, Li; He, Fenglan; Kong, Jian

doi:10.2147/cmar.s240000

Cited by 18 publications

(15 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These target genes generally exert a protumor activity by promoting proliferation, migration, or angiogenesis in cancer cells. A few lncRNAs have been found to regulate miR-424-5p in various cancer cells, including LINC00922 in breast cancer [ 39 ], CDNK2B-AS1 in hepatocellular carcinoma [ 40 ], and XIST in neuroendocrine tumors [ 41 ]. In all the aforementioned cases, regulation of miR-424-5p by the corresponding lncRNA resulted in cell proliferation or cancer-progression alterations.…”

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3 Prevents Oncogenic Long Noncoding RNA ATXN8OS from Inhibiting Tumor-Suppressive microRNA-424-5p in Breast Cancer Cells

Kim

et al. 2021

Biomolecules

View full text Add to dashboard Cite

Ginsenoside Rg3 exerts antiproliferation activity on cancer cells by regulating diverse noncoding RNAs. However, little is known about the role of long noncoding RNAs (lncRNAs) or their relationship with competitive endogenous RNA (ceRNA) in Rg3-treated cancer cells. Here, a lncRNA (ATXN8OS) was found to be downregulated via Rg3-mediated promoter hypermethylation in MCF-7 breast cancer cells. SiRNA-induced downregulation of ATXN8OS decreased cell proliferation but increased apoptosis, suggesting that the noncoding RNA possessed proproliferation activity. An in silico search for potential ATXN8OS-targeting microRNAs (miRs) identified a promising candidate (miR-424-5p) based on its high binding score. As expected, miR-424-5p suppressed proliferation and stimulated apoptosis of the MCF-7 cells. The in silico miR-target-gene prediction identified 200 potential target genes of miR-424-5p, which were subsequently narrowed down to seven that underwent hypermethylation at their promoter by Rg3. Among them, three genes (EYA1, DACH1, and CHRM3) were previously known oncogenes and were proven to be oppositely regulated by ATXN8OS and miR-424-5p. When taken together, Rg3 downregulated ATXN8OS that inhibited the tumor-suppressive miR-424-5p, leading to the downregulation of the oncogenic target genes.

show abstract

Section: Discussionmentioning

confidence: 99%

Ginsenoside Rg3 Prevents Oncogenic Long Noncoding RNA ATXN8OS from Inhibiting Tumor-Suppressive microRNA-424-5p in Breast Cancer Cells

Kim

et al. 2021

Biomolecules

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that CDKN2B-AS1 is highly expressed in various cancer types and serves as an oncogenic factor by regulating multiple cellular events such as apoptosis [ 136 , 137 ]. Further evidence showed that CDKN2B-AS1 interacts with miR-411–3p, which directly targets HIF-1α in ovarian cancer [ 138 ].…”

Section: Lncrnas Regulating Hif-1α Expressionmentioning

confidence: 99%

The Hypoxia–Long Noncoding RNA Interaction in Solid Cancers

Son

Yun

Song

et al. 2021

IJMS

View full text Add to dashboard Cite

Hypoxia is one of the representative microenvironment features in cancer and is considered to be associated with the dismal prognosis of patients. Hypoxia-driven cellular pathways are largely regulated by hypoxia-inducible factors (HIFs) and notably exert influence on the hallmarks of cancer, such as stemness, angiogenesis, invasion, metastasis, and the resistance towards apoptotic cell death and therapeutic resistance; therefore, hypoxia has been considered as a potential hurdle for cancer therapy. Growing evidence has demonstrated that long noncoding RNAs (lncRNAs) are dysregulated in cancer and take part in gene regulatory networks owing to their various modes of action through interacting with proteins and microRNAs. In this review, we focus attention on the relationship between hypoxia/HIFs and lncRNAs, in company with the possibility of lncRNAs as candidate molecules for controlling cancer.

show abstract

“…LncRNAs have also been implicated in stem cell maintenance and differentiation, cell autophagy and apoptosis, and embryonic development ( Qian et al, 2019 ). The expression of specific lncRNAs is altered in many cancers, suggesting that lncRNAs contribute to tumorigenesis and/or tumor cell function ( Xia et al, 2019 ; Qi-Dong et al, 2020 ; Shen et al, 2020 ; Ren et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

LncRNA GACAT3: A Promising Biomarker and Therapeutic Target in Human Cancers

Yuan

Dong

Shen

2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Long non-coding RNAs (lncRNAs) are a class of functional RNA molecules that do not encode proteins and are composed of more than 200 nucleotides. LncRNAs play important roles in epigenetic and gene expression regulation. The oncogenic lncRNA GACAT3 was recently discovered to be dysregulated in many tumors. Aberrant expression of GACAT3 contributes to clinical characteristics and regulates multiple oncogenic processes. The association of GACAT3 with a variety of tumors makes it a promising biomarker for diagnosis, prognosis, and targeted therapy. In this review, we integrate the current understanding of the pathological features, biological functions, and molecular mechanisms of GACAT3 in cancer. Additionally, we provide insight into the utility of GACAT3 as an effective diagnostic and prognostic marker for specific tumors, which offers novel opportunities for targeted therapeutic intervention.

show abstract

<p>LncRNA CDKN2B-AS1 Promotes Cell Viability, Migration, and Invasion of Hepatocellular Carcinoma via Sponging miR-424-5p</p>

Cited by 18 publications

References 42 publications

Ginsenoside Rg3 Prevents Oncogenic Long Noncoding RNA ATXN8OS from Inhibiting Tumor-Suppressive microRNA-424-5p in Breast Cancer Cells

Ginsenoside Rg3 Prevents Oncogenic Long Noncoding RNA ATXN8OS from Inhibiting Tumor-Suppressive microRNA-424-5p in Breast Cancer Cells

The Hypoxia–Long Noncoding RNA Interaction in Solid Cancers

LncRNA GACAT3: A Promising Biomarker and Therapeutic Target in Human Cancers

Contact Info

Product

Resources

About