LncRNA GACAT3: A Promising Biomarker and Therapeutic Target in Human Cancers

Yuan, Xin; Dong, Zihui; Shen, Shen

doi:10.3389/fcell.2022.785030

Cited by 8 publications

(3 citation statements)

References 88 publications

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“…Metastasis, a hallmark of cancer, was a complicated multistep process involving cell adhesion, invasion, and migration ( 84 ). It has been documented that SNHG15 modulates tumor metastasis primarily by regulating EMT, a pro-metastasis process that enabled cells to migrate more efficiently and invade the underlying mesenchyme ( 85 ).…”

Section: Biological Significance In the Hallmarks Of Cancermentioning

confidence: 99%

Long noncoding RNA SNHG15: A promising target in human cancers

Zhang

Lei

et al. 2023

Front. Oncol.

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As oncogenes or tumor suppressor genes, lncRNAs played an important role in tumorigenesis and the progression of human cancers. The lncRNA SNHG15 has recently been revealed to be dysregulated in malignant tumors, suggesting the aberrant expression of which contributes to clinical features and regulates various oncogenic processes. We have selected extensive literature focused on SNHG15 from electronic databases, including studies relevant to its clinical significance and the critical events in cancer-related processes such as cell proliferation, apoptosis, autophagy, metastasis, and drug resistance. This review summarized the current understanding of SNHG15 in cancer, mainly focusing on the pathological features, known biological functions, and underlying molecular mechanisms. Furthermore, SNHG15 has been well-documented to be an effective diagnostic and prognostic marker for tumors, offering novel therapeutic interventions in specific subsets of cancer cells.

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Section: Biological Significance In the Hallmarks Of Cancermentioning

confidence: 99%

Long noncoding RNA SNHG15: A promising target in human cancers

Zhang

Lei

et al. 2023

Front. Oncol.

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“…Cancer remains one of the main causes of death in humans. The latest breakthrough in cancer research is the discovery and application of lncRNAs in cancer therapy [ 40 ]. Abnormal DLEU2 expression in cancer cells regulates the occurrence and development of tumors through a ceRNA mechanism [ 3 ], suggesting that DLEU2 is a potential therapeutic target.…”

Section: Clinical Application Of Dleu2mentioning

confidence: 99%

Deleted in lymphocytic leukemia 2 (DLEU2): a possible biomarker that holds promise for future diagnosis and treatment of cancer

Cao

Xing

et al. 2023

Clin Transl Oncol

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The mechanism of deleted in lymphocytic leukemia 2 (DLEU2)-long non-coding RNA in tumors has become a major point of interest in recent research related to the occurrence and development of a variety of tumors. Recent studies have shown that the long non-coding RNA DLEU2 (lncRNA-DLEU2) can cause abnormal gene or protein expression by acting on downstream targets in cancers. At present, most lncRNA-DLEU2 play the role of oncogenes in different tumors, which are mostly associated with tumor characteristics, such as proliferation, migration, invasion, and apoptosis. The data thus far show that because lncRNA-DLEU2 plays an important role in most tumors, targeting abnormal lncRNA-DLEU2 may be an effective treatment strategy for early diagnosis and improving the prognosis of patients. In this review, we integrated lncRNA-DLEU2 expression in tumors, its biological functions, molecular mechanisms, and the utility of DLEU2 as an effective diagnostic and prognostic marker of tumors. This study aimed to provide a potential direction for the diagnosis, prognosis, and treatment of tumors using lncRNA-DLEU2 as a biomarker and therapeutic target.

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“…Its regulatory processes are regulated by signaling molecules whose interactions with neighboring cells induce appropriate transcriptional and epigenetic responses 34 . The way epigenetic mechanisms regulate gene expression which is related to environmental factors, plays an important role in the development of various diseases such as tumors and in ammation 35,36 . In addition, epigenetic regulatory mechanisms may also affect the shape and size of teeth 5 .…”

Section: Epigenetic Regulations Of Odontogenic Stem Cellsmentioning

confidence: 99%

Epigenetic regulation of odontogenic stem cells and their application in pulp and periodontal regeneration

Wang

Chen

et al. 2022

Preprint

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Dental-derived stem cells, an important research target in tissue engineering, have excellent proliferation ability and multi-directional differentiation potential. In recent years, an increasing number of odontogenic stem cells have been discovered, including dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous tooth (SHEDs), apical papilla stem cells (SCAPs), dental follicle precursor cells (DFPCs) and periodontal ligament stem cells (PDLSCs). Due to the advantages of abundant sources, safe and effective, these stem cells have significant application prospects in tissue regeneration. The biological functions of odontogenic stem cells are regulated in many ways. Epigenetic regulation means changing the expression level and function of a gene without changing its sequence. Epigenetic regulation is involved in many biological processes, such as embryonic development, bone homeostasis, and stem cell fate. Existing studies have shown that odontogenic stem cells are also regulated by epigenetic modifications. Referring to replacing damaged pulp and periodontal tissue and restoring the tissue structure and function under normal physiological conditions, pulp regeneration and periodontal regeneration has better therapeutic effect than traditional treatments. This article reviews the recent research progress on the epigenetic regulation mechanism of odontogenic stem cells, and describes the potential applications of odontogenic stem cells-based epigenetic regulation in dental pulp and periodontal regeneration.

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LncRNA GACAT3: A Promising Biomarker and Therapeutic Target in Human Cancers

Cited by 8 publications

References 88 publications

Long noncoding RNA SNHG15: A promising target in human cancers

Long noncoding RNA SNHG15: A promising target in human cancers

Deleted in lymphocytic leukemia 2 (DLEU2): a possible biomarker that holds promise for future diagnosis and treatment of cancer

Epigenetic regulation of odontogenic stem cells and their application in pulp and periodontal regeneration

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