Regulação da expressão gênica das UCP2 e UCP3 pela restrição energética,jejum e exercício físico

Boschini, Renata Polessi; Júnior, Jair Rodrigues Garcia

doi:10.1590/s1415-52732005000600006

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…The uncoupling of respiration and the dissipation of heat are important keys to energy balance [21]. When a stimulus occurs to a UCP, energy is not taken to the phosphorylation of the ADP, and heat is generated [26,27]. Also, UCPs are involved in other cellular processes such as mitochondrial free radical production [28].…”

Section: Discussionmentioning

confidence: 99%

Low-level lasers affect uncoupling protein gene expression in skin and skeletal muscle tissues

et al. 2016

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Wavelength, frequency, power, fluence, and emission mode determine the photophysical, photochemical, and photobiological responses of biological tissues to low-level lasers. Free radicals are involved in these responses acting as second messengers in intracellular signaling processes. Irradiated cells present defenses against these chemical species to avoid unwanted effects, such as uncoupling proteins (UCPs), which are part of protective mechanisms and minimize the effects of free radical generation in mitochondria. In this work UCP2 and UCP3 mRNA gene relative expression in the skin and skeletal muscle tissues of Wistar rats exposed to low-level red and infrared lasers was evaluated. Samples of the skin and skeletal muscle tissue of Wistar rats exposed to low-level red and infrared lasers were withdrawn for total RNA extraction, cDNA synthesis, and the evaluation of gene expression by quantitative polymerase chain reaction. UCP2 and UCP3 mRNA expression was differently altered in skin and skeletal muscle tissues exposed to lasers in a wavelength-dependent effect, with the UCP3 mRNA expression dose-dependent. Alteration on UCP gene expression could be part of the biostimulation effect and is necessary to make cells exposed to red and infrared low-level lasers more resistant or capable of adapting in damaged tissues or diseases.

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Section: Discussionmentioning

confidence: 99%

Low-level lasers affect uncoupling protein gene expression in skin and skeletal muscle tissues

et al. 2016

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“…In addition, CLA has shown to increase adiponectin, an anti-inflammatory hormone that lowers gluconeogenesis, and reduces circulating levels of leptin [ 77 , 90 ]; however, one study revealed that leptin and adiponectin levels were unaffected by CLA supplementation [ 91 ]. Another plausible mechanism by which CLA modulates body composition and weight loss is related to PPARs, especially PPARγ, as CLA can reduce the expression of lipogenesis-related genes and decrease body fat by inhibiting PPARγ [ 92 ].…”

Section: Cla Effects On Body Compositionmentioning

confidence: 99%

The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: a comprehensive review of putative molecular mechanisms

Putera,

Doewes,

Shalaby

et al. 2023

Nutr Metab (Lond)

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Conjugated linoleic acids (CLAs) are polyunsaturated fatty acids primarily found in dairy products and ruminant animal products such as beef, lamb, and butter. Supplementation of CLAs has recently become popular among athletes due to the variety of health-promoting effects, including improvements in physical performance. Preclinical and some clinical studies have shown that CLAs can reduce inflammation and oxidative stress and favorably modulate body composition and physical performance; however, the results of previously published clinical trials are mixed. Here, we performed a comprehensive review of previously published clinical trials that assessed the role of CLAs in modulating inflammation, oxidative stress, body composition, and select indices of physical performance, emphasizing the molecular mechanisms governing these changes. The findings of our review demonstrate that the effect of supplementation with CLAs on inflammation and oxidative stress is controversial, but this supplement can decrease body fat mass and increase physical performance. Future well-designed randomized clinical trials are warranted to determine the effectiveness of (1) specific doses of CLAs; (2) different dosing durations of CLAs; (3) various CLA isomers, and the exact molecular mechanisms by which CLAs positively influence oxidative stress, inflammation, body composition, and physical performance.

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“…O jejum é caracterizado pela supressão da ingestão de alimentos por um período prolongado 1 . Vários profissionais de saúde assim como o senso comum, defendem que praticar exercícios físicos em jejum pode potencializar os efeitos da prática regular de atividades físicas com objetivo de emagrecimento 2 .…”

Section: Introductionunclassified

Efeito de 12 semanas de treinamento aeróbio em jejum sobre o emagrecimento

et al. 2015

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ResumoO presente estudo objetivou verificar o efeito de 12 semanas de treinamento aeróbio em jejum sobre o emagrecimento, sendo realizado entre outubro de 2014 e março de 2015 na Faculdade Pitágoras da cidade de Betim/MG. A amostra constituiu de 33 mulheres sedentárias, sem doenças metabólicas. Inicialmente as voluntárias foram submetidas à avaliações da capacidade aeróbica (Balke-Ware) e composição corporal, sendo registrada a massa corporal total (MCT), massa muscular, massa gorda (MG) e percentual de gordura corporal (PGC), por meio de bioimpedância tetrapolar. Em seguida, as voluntárias foram divididas randomicamente em três grupos, que realizaram treinamento aeróbio em esteira elétrica. Um dos grupos realizou o treinamento em jejum (GJ) no período pós-absortivo, com baixa intensidade (50% da frequência cardíaca de reserva), enquanto que outro grupo realizou o mesmo treinamento, mas em estado alimentado (GA). O terceiro grupo percorreu as mesmas distâncias dos outros grupos, mas com elevada intensidade (GEI) (70% da FC de reserva), no estado alimentado. Para comparar a composição corporal e capacidade aeróbica antes e após o treinamento foi utilizado o teste t pareado, enquanto que para comparar a variação percentual da MCT e do PGC dos grupos foi utilizado o teste ANOVA one-way. Os AbstractThis study aimed to verify 12 weeks of aerobic training effect on fasting weight loss performed between October 2014 and March 2015 at Pitágoras a city in Betim/MG. The sample was 33 sedentary women without metabolic diseases. Initially the volunteers were submitted to aerobic capacity test (Balke-Ware) and body composition evaluation. It was recorded the total body mass (TBM), muscle mass (MM), fat mass (FM) and percentage of body fat (PBF) by tetrapolar bioimpedance. Then the volunteers were randomly divided into three groups, who performed aerobic training in a treadmill. One group performed the training in fasting (FT) in the post-absorptive period, with low intensity (50% of the heart rate reserve), while another group performed the same training, but in fed state (PT). The third group ran the same distance from the other groups, but with higher intensity (HIT) (70% of the heart rate reserve) in fed state. To compare body composition and aerobic capacity before and after training it was used the paired t test, while to compare the percentage change of MCT and the PGC between groups it was used the ANOVA one-way test. The results showed that the aerobic capacity increased in all groups, but the increase was greater in the HIT. Further, the HIT presented a significant reduction in FM and PBF, while the FT and PT groups showed no significant changes in body composition. No significant differences were found between the groups in relation to variation of PGC and PBF. It was concluded that fasted aerobic training has no additional effect on weight loss.

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Regulação da expressão gênica das UCP2 e UCP3 pela restrição energética,jejum e exercício físico

Cited by 8 publications

References 48 publications

Low-level lasers affect uncoupling protein gene expression in skin and skeletal muscle tissues

Low-level lasers affect uncoupling protein gene expression in skin and skeletal muscle tissues

The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: a comprehensive review of putative molecular mechanisms

Efeito de 12 semanas de treinamento aeróbio em jejum sobre o emagrecimento

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