2007
DOI: 10.1080/17453670710014419
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Regression of heterotopic ossification after starting warfarin—an effect mediated by inhibition of γ-carboxylation of osteocalcin?—a case report

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Cited by 5 publications
(3 citation statements)
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“…Warfarin is a vitamin K antagonist that is able to inhibit γ-carboxlyation of osteocalcin, which has a role in bone formation, so Warfarin had been introduced to diminishing of heterotopic ossifications (7). There had been trials to evaluate the role of bisphosphonate and warfarin in delaying or preventing ectopic ossification in pulmonary tissue, but the results remain to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…Warfarin is a vitamin K antagonist that is able to inhibit γ-carboxlyation of osteocalcin, which has a role in bone formation, so Warfarin had been introduced to diminishing of heterotopic ossifications (7). There had been trials to evaluate the role of bisphosphonate and warfarin in delaying or preventing ectopic ossification in pulmonary tissue, but the results remain to be determined.…”
Section: Discussionmentioning
confidence: 99%
“…Some non-surgical therapies for the treatment of MOT have been proposed but there is no clinical evidence of their effectiveness [7]. Administration of local magnesium sulfate injections associated with the use of oral magnesium lactate, low doses of radiotherapy, use of bisphosphonates, indomethacin, Celecoxib, warfarin and injections of steroidal anti-inflammatory drugs were described in literature; however, without consensus regarding dosage and results obtained [1,7,14,20,21].…”
Section: Statement Of Clinical Relevancementioning
confidence: 99%
“…Дієта з низьким вмістом кальцію, кальцій-зв'язувальні препарати і кортикостероїди не показали ефективності [8]. Існує повідомлення про зменшення гетеротопічного окостеніння після тривалого лікування варфарином [18]. Враховуючи відсутність визначених схем терапії, лікування залишається симптоматичним.…”
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