REGIONAL RENAL HYPOTHERMIA ¹

Twenty-four-hour preservation of canine kidneys exposed to 45 and 60 minutes of warm ischaemia

“…I n this animal the early renal function was poor but the serum creatinine had fallen to In cadaveric renal transplantation a period of warm ischaemia inevitably occurs between asystole in the donor and the onset of renal preservation. Wickham, Hanley, and Joekes (1967) demonstrated in the rabbit that increasing periods of warm ischaemia lead to progressively more severe impairment of renal function and that recovery is seldom complete if the period of warm ischaemia exceeds 60 minutes. Organ-sharing schemes designed to distribute kidneys on the basis of histocompatibility matching require reliable short-term renal preservation whilst tissue typing and transfer of organs are effected.…”

The Laparoscopic Cooling Sheath: Novel Device for Hypothermic Preservation of Kidney during Temporary Renal Artery Occlusion

“…The "normal" kidney can tolerate complete arterial ischemia at normal physiologic temperatures for approximately 30 The cell biology of ischémie renal injury is multifactorial. Calcium influx with increased cell permeability, depletion of ATP, mitochondrial dysfunction, and the eventual production of cytotoxic free radicals result in cell membrane damage and death.2 Various pharmacologie strategies utilizing drugs that block this cascade of intracellular events have been described.…”

Microcontroller based hypothermia system

“…Renal artery clamp was left about two hours with ice-slush hypothermia. This duration was extended to 4 hours in some events [9,11,14]. In practise, 20 o C and artery occlusion can provide operations with two hours [9,14].…”

“…This duration was extended to 4 hours in some events [9,11,14]. In practise, 20 o C and artery occlusion can provide operations with two hours [9,14]. In the methods of ice-slush and Cockett, cooling the kidney requires 15-20 minutes whereas steady hypothermia over every part of the kidney is provided with ice-slush [2].…”