Twenty-four-hour preservation of canine kidneys exposed to 45 and 60 minutes of warm ischaemia

This investigation was designed to test the ability of a new hyperbaric organ preservation system to preserve canine kidneys for 24 hours after they had been subjected to significant periods of warm ischaemia. In group I (45 minutes of warm ischaemia) all the kidneys functioned well, and the mean maximum serum creatinine was 4.4 ± 1.7 mg. per 100 ml. In group II (60 minutes of warm ischaemia) I dog died on account of acute tubular necrosis. The mean maximum serum creatinine was 5.4 ± 4.02 mg. per 100 ml. The results indicate that hyperbaric oxygen warrants serious consideration as an adjunct to organ preservation.

show abstract

Twenty-four-hour preservation of canine kidneys exposed to 45 and 60 minutes of warm ischaemia

Snell

Hopkinson²,

Porter

1972

Journal of British Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

Kidney Preservation

Johnson¹

1987

Clinical Transplantation

View full text Add to dashboard Cite

Supplemental oxygen during hypothermic kidney preservation: A systematic review

O’Callaghan

Pall

Pengel

2017

Transplantation Reviews

View full text Add to dashboard Cite

We reviewed the evidence for ex-vivo Supplemental Oxygen during Hypothermic preservation (SOH) for deceased donor kidneys. Bibliographic databases were searched for human and animal studies of SOH in kidney transplantation reporting on patient or animal survival rate, discard rate, technical complications or renal function outcomes. We make special reference to a specific subgroup: supplemental oxygen applied during cold perfusion, referred to as Hypothermic Oxygenated Perfusion (HOP). Four human and 25 animal studies were identified. The data present conflicting results but suggest that the effects of oxygen on restoring kidney function during preservation may be of value for DCD kidneys and/or kidneys that have undergone a period of hypotension, warm ischemia or poor perfusion in the donor. There is very little information available from human or animal studies. This work highlights to the transplant community that far more high quality clinical studies are required to understand this technology and its role before widespread clinical introduction.

show abstract

Twenty-four-hour preservation of canine kidneys exposed to 45 and 60 minutes of warm ischaemia

Cited by 6 publications

References 12 publications