Regional distribution and incidence of human papillomavirus infections among heterosexual men and women with multiple sexual partners: a prospective study.

Doornum, G J van; Prins, Maria; Juffermans, Leon H. J.; Hooykaas, C.; Hoek, J. van den; Coutinho, R. A.; Quint, Wim

doi:10.1136/sti.70.4.240

Cited by 69 publications

(92 citation statements)

References 21 publications

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“…In the present study, as in others [10,13,16,36], age was not associated with HPV prevalence among men. In women, HPV infection declines with increasing age, with a smaller postmenopausal peak observed in some populations [37][38][39][40].…”

Section: Discussionsupporting

confidence: 65%

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Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

et al. 2003

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Human papillomavirus (HPV) is the main etiologic agent of anogenital cancers, including cervical cancer, but little is known about the type-specific prevalence of HPV in men. Participants were men aged 18-70 years attending a sexually transmitted disease clinic. Penile skin swabs were assessed for HPV DNA using polymerase chain reaction with reverse line-blot genotyping. Of 436 swabs collected, 90.1% yielded sufficient DNA for HPV analysis. Men with inadequate swab samples were significantly more likely to be white and circumcised than men with adequate swab samples. The prevalence of HPV was 28.2%. Oncogenic HPV types were found in 12.0% of participants, nononcogenic types were found in 14.8% of participants, multiple types were found in 6.1% of participants, and unknown types were found in 5.9% of participants. The most prevalent subtypes were nononcogenic 6, 53, and 84. HPV positivity was not associated with age. These results indicate that HPV infection among men at high risk is common but that characteristics of male HPV infection may differ from those of female infection.Human papillomavirus (HPV) infection is the necessary, sexually transmitted cause of invasive cervical cancer and its precursor lesion, cervical intraepithelial neoplasia [1][2][3]. HPV has also been closely linked with other anogenital cancers, including anal cancer and certain penile cancers [4][5][6]. HPV infection in men is over- whelmingly subclinical, which has resulted in a potentially large number of asymptomatic carriers who serve as reservoirs and vectors for the virus.Although HPV has been studied extensively in women, data on male infection are limited. Studies of HPV in men are necessary to improve our understanding of HPV transmission and HPV-related carcinogenesis and to prevent disease in both men and women. The success of future cancer prevention strategies, such as prophylactic HPV vaccination, will be limited without a basic epidemiological understanding of HPV in men.Earlier studies of papillomavirus infection in men used a variety of clinical and histological techniques to establish a diagnosis of HPV, but polymerase chain reaction (PCR) has emerged as the most sensitive method available for the detection of latent HPV [7][8][9]. Among studies that have used PCR to detect penile HPV DNA in healthy men, sampling methodologies have been inconsistent. Nonetheless, results from these diverse investigations have suggested that penile HPV in sexually active men is at least as prevalent as cervical HPV is among women [10][11][12][13][14][15].HPV prevalence in men has been shown to vary by

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Section: Discussionsupporting

confidence: 65%

“…Among studies that have used PCR to detect penile HPV DNA in healthy men, sampling methodologies have been inconsistent. Nonetheless, results from these diverse investigations have suggested that penile HPV in sexually active men is at least as prevalent as cervical HPV is among women [10][11][12][13][14][15].…”

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confidence: 99%

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

et al. 2003

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“…Time to clearance depends both on virus-and host-related factors (6), with possibly longer persistence of high-risk (oncogenic) HPV types, such as HPV-16, compared to low-risk types (7), and shorter persistence in heterosexual men compared to women (8)(9)(10)(11). In immunocompromised people, persistent HPV infection is more common (12,13).…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of High-Risk HPV in HIV-Negative and HIV-Infected MSM: The H2M Study

Mooij

Klis

Sande

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Men who have sex with men (MSM), in particular HIV-infected MSM, are at increased risk for diseases related to human papilloma virus (HPV). Our goal was to assess the effect of HIV status on the presence of type-specific antibodies against seven high-risk HPV types in HPV-unvaccinated MSM. Moreover, we compared determinants of HPV seropositivity between HIV-negative and HIV-infected MSM.Methods: MSM !18 years of age were recruited from the Amsterdam Cohort Studies, a sexually transmitted infection clinic, and an HIV-treatment center in Amsterdam, the Netherlands. Participants completed a riskfactor questionnaire; serum samples were analyzed using a fluorescent bead-based multiplex assay.Results: MSM (n ¼ 795) were recruited in 2010 to 2011; 758 MSM were included in this analysis. Median age was 40.1 years (interquartile range 34.8-47.5) and 308 MSM (40.6%) were HIV-infected. Seroprevalence of HPV-16 was 37.1% in HIV-negative and 62.7% in HIV-infected MSM (P < 0.001); seroprevalence of HPV-18 was 29.1% in HIV-negative MSM and 42.5% in HIV-infected MSM (P < 0.001). Similar patterns of seroprevalence were observed for HPV types 31, 33, 45, 52, and 58. In multivariable analyses, HPV seropositivity was associated with HIV infection [adjusted OR ¼ 2.1; 95% confidence interval, 1.6-2.6]. In multivariable analyses stratified by HIV status, increasing age and number of lifetime male sex partners were significantly associated with HPV seropositivity in HIV-negative, but not HIV-infected MSM.Conclusions: Seroprevalence of high-risk HPV types is high among unvaccinated MSM. Impact: HIV infection is a strong and independent determinant for HPV seropositivity, which we hypothesize is because of increased persistence of HPV infection in HIV-infected MSM. Cancer Epidemiol Biomarkers Prev; 22(10); 1698-708. Ó2013 AACR.

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“…To our knowledge, there are 9 documented scientific articles on 8 prospective studies on HPV infection in men (7)(8)(9)(10)(11)(12)(13)(14)(15). All of them provide information on incidence rates and 8 describe the persistence or clearance of HPV (7)(8)(9)(10)(11)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

HPV in Female Partners Increases Risk of Incident HPV Infection Acquisition in Heterosexual Men in Rural Central Mexico

Morales

Parada

Giuliano

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Knowledge about the incidence, clearance, and factors associated with human papilloma virus (HPV) infection in men is lacking, and much of what is available focuses on high-risk groups.Methods: A prospective cohort study was carried out with 504 heterosexual males from Mexico State, Mexico. Participants were monitored for 4 years at intervals of approximately 4 months, with a median total duration of follow-up of 19.8 months. The presence of cervical HPV in female sexual partners was evaluated as a risk factor. HPV DNA testing was conducted using the polymerase chain reaction technique. Risk factors associated with the incidence and clearance of HPV infection were evaluated through survival analysis.Results: The cumulative incidence of infection with any HPV type at 12 months was 15% [95% confidence interval (CI), 0.12-0.20]. About 72% of men with incident HPV cleared the infection by 12 months. The presence of cervical HPV in a man's female sex partner was the main determinant for males acquiring HPV infection of any type [adjusted HR (AHR), 2.1; 95% CI, 1.1-3.8] and oncogenic HPV infection (AHR, 4.1; 95% CI, 2.1-8.0), while having a history of anal sexual relations with women was statistically associated with acquiring nononcogenic HPV (AHR, 1.8; 95% CI, 1.1-2.9).Conclusions and Impact: The incidence of genital HPV infection in this population is relatively low, with relatively quick acquisition and clearance rates. Cervical HPV infection in men's female sexual partners was the main risk factor for genital HPV infection in men. Cancer Epidemiol Biomarkers Prev; 21(11); 1956-65. Ó2012 AACR.

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Regional distribution and incidence of human papillomavirus infections among heterosexual men and women with multiple sexual partners: a prospective study.

Cited by 69 publications

References 21 publications

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

Human Papillomavirus Infection in Men Attending a Sexually Transmitted Disease Clinic

Seroepidemiology of High-Risk HPV in HIV-Negative and HIV-Infected MSM: The H2M Study

HPV in Female Partners Increases Risk of Incident HPV Infection Acquisition in Heterosexual Men in Rural Central Mexico

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