Regional Changes and Changes Caused by Age in the Normal Skin

Hill, William R.; Montgomery, Hamilton

doi:10.1038/jid.1940.17

Cited by 68 publications

(9 citation statements)

References 4 publications

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“…The most consistent finding in the epidermis of aging individuals is flattening of the dermal‐epidermal junction and effacement of the rete ridge pattern 2,3 (Fig. 1).…”

Section: The Epidermismentioning

confidence: 68%

Histologic Changes in Skin Associated with Aging

Kurban

Bhawan

1990

The Journal of Dermatologic Surgery and Oncology

181

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This is a review of histologic changes noted in the skin of elderly individuals. Among the epidermal changes associated with skin aging are a flattened dermal-epidermal junction, giving the appearance of atrophy and cellular heterogeneity. The melanocyte density declines slowly, and the Langerhans cells decrease in number with advancing age. Among the dermal changes are attenuation in the number and diameter of elastic fibers in the papillary dermis, an increase in number and thickness of the same fibers in the reticular dermis, and a coarsening of collagen fibers with an increase in density of the collagen network. A decrease in the dermal cell population as well as a functional decline in glandular activity are also noted with intrinsic aging. A decline in hair number, rate of growth, and diameter, along with a slowing of the rate of growth of nails, have been well documented with progressive aging.

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“…The most consistent finding in the epidermis of aging individuals is flattening of the dermal‐epidermal junction and effacement of the rete ridge pattern 2,3 (Fig. 1).…”

Section: The Epidermismentioning

confidence: 68%

Histologic Changes in Skin Associated with Aging

Kurban

Bhawan

1990

The Journal of Dermatologic Surgery and Oncology

181

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“…Histologic features associated with aging of human skin are listed in Table 1. The most striking and consistent change is flattening of the dermoepidermal junction with effacement of both the dermal papillae and epidermal rete pegs, 3,4 shown schematically in Figure 1. This results in a much smaller contiguous surface between the two compartments, and presumably less “communication” and nutrient transfer, and less resistance to shearing forces.…”

Section: Age‐associated Chances In Normal Skinmentioning

confidence: 86%

Age‐associated Changes in the Skin

Gilchrest

1982

J American Geriatrics Society

119

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Like all organ systems, the skin manifests an age-associated loss of functional capacity and increasing vulnerability to injury and certain disease states. Knowledge of the aging changes in normal skin assists the physician in diagnosis and management of certain dermatoses. Awareness of the important interactions between aging skin and the environment could lead to prevention of many disorders. The burden of skin disease for the elderly is often underestimated. It is psychosocial as well as medical, and although mortality is low, morbidity is high. A rational and caring approach by the general practitioners, family physicians, internists, and geriatricians responsible for this patient population should greatly improve the situation.

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“…There have been disagreements concerning the difference in thickness of the elastic fibres between young and old skin (Hill & Montgomery, 1940;Dick, 1947;Ma & Cowdry, 1950;Marshall, 1965;Mitchell, 1967;Montagna, 1973;Jarrett, ^974) in light microscopic studies. This is reasonable since most elastic fibres of old skin are elliptical and appeared either thicker, thinner or unchanged when compared with those of the young skin, depending on how the fibres were cut.…”

Section: Discussionmentioning

confidence: 99%

Age-related changes in human dermal elastic fibres

Tsuji

Hamada

1981

Br J Dermatol

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Age-related changes in human dermal elastic fibres were studied by scanning (SEM) and transmission (TEM) electron microscopy. The SEM findings showed an increase in the complexity of shape and arrangement of the fibres including flattening and branching, an increase in the roughness of the surface, and a decrease in interfibrillar areas. The TEM findings showed a decrease in micro-fibrils and amorphous material, and an increase in electron dense inclusions followed by the appearance of vesicular structure.

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Regional Changes and Changes Caused by Age in the Normal Skin

Cited by 68 publications

References 4 publications

Histologic Changes in Skin Associated with Aging

Histologic Changes in Skin Associated with Aging

Age‐associated Changes in the Skin

Age-related changes in human dermal elastic fibres

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