Histologic Changes in Skin Associated with Aging

Kurban, Ramsay S.; Bhawan, Jag

doi:10.1111/j.1524-4725.1990.tb01554.x

Cited by 181 publications

(96 citation statements)

References 47 publications

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“…Dermal connective tissue changes induced by long-term UV irradiation lead to light skin damage and the appearance of aging (25). As the primary producers of the ECM scaffold, dermal fibroblasts are the basis of the occurrence of photoaging (8,26,27).…”

Section: Discussionmentioning

confidence: 99%

GSK126 (EZH2 inhibitor) interferes with ultraviolet A radiation‑induced photoaging of human skin fibroblast cells

2018

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Abstract. Polycomb group genes (PcG) encode chromatin modification proteins that are involved in the epigenetic regulation of cell differentiation, proliferation and the aging processes. The key subunit of the PcG complex, enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), has a central role in a variety of mechanisms, such as the formation of chromatin structure, gene expression regulation and DNA damage. In the present study, ultraviolet A (UVA) was used to radiate human dermal fibroblasts in order to construct a photo-aged cell model. Subsequently, the cell viability assay, Hoechst staining, apoptosis detection using flow cytometry, senescence-associated β-galactosidase (SA-β-gal) staining and erythrocyte exclusion experiments were performed. GSK126, a histone methylation enzyme inhibitor of EZH2, was used as an experimental factor. Results suggested that GSK126 downregulated the mRNA expression levels of EZH2 and upregulated the mRNA expression levels of BMI-1. Notably, GSK126 affected the transcription of various photoaging-related genes and thus protected against photoaging induced by UVA radiation.

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Section: Discussionmentioning

confidence: 99%

GSK126 (EZH2 inhibitor) interferes with ultraviolet A radiation‑induced photoaging of human skin fibroblast cells

2018

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“…8 Outra causa do aparecimento da HPO é o sombreamento devido à flacidez da pele e fossa lacrimal, associado ao envelhecimento. 6 De acordo com Kurban e Bhawan, 10 com o tempo o colágeno e a elastina sofrem danos das radiações ultravioleta, ocasionando o afinamento e envelhecimento da pele, conforme descrito por Bucay e Day. 2 A flacidez da pele em decorrência do fotoenvelhecimento leva à aparência de sombra nas pálpebras inferiores, resultando no aparecimento da HPO (Figura 1).…”

Section: Etiopatogenia Da Hipercromia Periorbitalunclassified

Causas e tratamento da hipercromia periorbital

Oliveira

Paiva

2016

Rev. Fac. Ciênc. Méd. Sorocaba

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RESUMOA região periorbital é uma das primeiras áreas a mostrar sinais do envelhecimento, como rugas, flacidez e hiperpigmentação periorbital (HPO). A HPO interfere na aparência facial provocando aspecto de cansaço, tristeza ou ressaca. Possui etiopatogenia complexa que inclui múltiplos fatores que podem ser de causa primária ou secundária. Os fatores genéticos são considerados de causa primária, enquanto os ambientais são de causa secundária. Assim, são exemplos de fatores ambientais o excesso de exposição solar, a hiperpigmentação pós-inflamatória, o excesso de vascularização subcutânea, a hipertransparência da pele, o edema periorbital e a herniação da gordura palpebral. A gravidade clínica da doença pode variar e geralmente a hiperpigmentação está presente bilateralmente e simetricamente ao redor dos olhos. O propósito deste estudo foi realizar uma revisão integrativa com o objetivo de discutir e avaliar as causas e fatores etiológicos e descrever os possíveis tratamentos disponíveis na literatura. Foram utilizados 26 artigos que abordavam os temas: anatomia, etiologia, causas e tratamentos. Tendo em vista a escassez de informações sobre a etiologia, bem como um tratamento consensual, é necessário um exame clínico adequado para direcionar a conduta. Existem várias sugestões para tratamento da HPO descritos, como peeling, preenchimento com gordura autóloga, laser, utilização de cosméticos, injeções de plasma rico em plaquetas e carboxiterapia. Palavras-chave: envelhecimento da pele; pálpebras; hiperpigmentação; edema; técnicas cosméticas. ABSTRACTThe periorbital region is one of the first areas to demonstrate signs of aging such as wrinkling, skin laxity and periorbital hyperpigmentation (HPO). The HPO interferes in the facial appearance resulting on a tired, sadness or hangover aspects. It has a complex etiopathogenesis with factors that could be by primary or secondary cause. The genetic factors are stated as a primary cause and the environmental factors are stated as a secondary cause. In that way, there are many examples of environmental factors such as excess of sun exposition, post inflammatory hyper pigmentation, excess of subcutaneous vascularization, hyper transparency of the skin, periorbital edema, and fat herniation eyelid. The clinical severity of the condition varies and normally the hyper pigmentation is present bilaterally and symmetrically around the eye region. The main objective of this study was to develop and evaluate the causes and etiological factors, and to describe the possible treatments available in the current literature. It was utilized 26 scientific papers on the following subjects: anatomy, etiology, causes and treatments. Owing to the information scarcity about its etiology, as well as its consensual treatment, it is necessary an adequate clinical examination in order to provide directions to the conduct. There are several suggestions for HPO treatment described: peeling, fillers, autologous fat fillers, cosmetic use, injection of platelet rich plasma (PRP), and carboxytherapy. ...

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“…The thickness of the epidermis remains fairly constant with age [10], but there is a flattening of the dermal-epidermal junction, which allows the appearance of atrophy [11]. In addition, the Textbook of Aging Skin DOI 10.1007/978-3-642-27814-3_136-1 # Springer-Verlag Berlin Heidelberg 2015 time taken by the keratinocytes to migrate from the basal layer to the skin surface, a key process in repair, increases by 50 % in the elderly [12].…”

Section: Characteristic Age-related Changes Of Normal Skinmentioning

confidence: 99%

“…In addition, there is a flattening of the papillary dermis, decreasing surface contact between the dermis and epidermis [13]. This predisposes separation of the dermal-epidermal junction with laterally applied tension [11]. Furthermore, the cellular content of the dermis (fibroblasts, mast cells, Langerhans cells, and macrophages) also decreases with age [14].…”

Section: Characteristic Age-related Changes Of Normal Skinmentioning

confidence: 99%

Aging Skin: Nourishing from Out-In. Lessons from Wound Healing

Corsetti

Flati

Pasini³

et al. 2015

Textbook of Aging Skin

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Skin lesion therapy, peculiarly in the elderly, cannot be isolated from understanding that the skin is an important organ consisting of different tissues. Furthermore, dermis health is fundamental for epidermis integrity, and so adequate nourishment is mandatory in maintaining skin integrity. The dermis nourishes the epidermis, and a healthy epidermis protects the dermis from the environment, so nourishing the dermis through the epidermal barrier is a technical problem yet to be resolved. This is also a consequence of the laws and regulations restricting cosmetics, which cannot have properties that pass the epidermal layer. There is higher investment in cosmetics than in the pharmaceutical industry dealing with skin therapies, because the costs of drug registration are enormous and the field is unprofitable. Still, wound healing may be seen as an opportunity to "feed" the dermis directly. It could also verify whether providing substrates could promote efficient healing and test optimal skin integrity maintenance, if not skin rejuvenation, in an ever aging population.

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Histologic Changes in Skin Associated with Aging

Cited by 181 publications

References 47 publications

GSK126 (EZH2 inhibitor) interferes with ultraviolet A radiation‑induced photoaging of human skin fibroblast cells

GSK126 (EZH2 inhibitor) interferes with ultraviolet A radiation‑induced photoaging of human skin fibroblast cells

Causas e tratamento da hipercromia periorbital

Aging Skin: Nourishing from Out-In. Lessons from Wound Healing

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